Transdifferentiation of pancreatic cells by loss of contact-mediated signaling

Replacement of dysfunctional β-cells in the islets of Langerhans by transdifferentiation of pancreatic acinar cells has been proposed as a regenerative therapy for diabetes. Adult acinar cells spontaneously revert to a multipotent state upon tissue dissociation in vitro and can be stimulated to redi...

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Veröffentlicht in:	BMC systems biology 2013-08, Vol.7 (1), p.77-77, Article 77
Hauptverfasser:	de Back, Walter, Zimm, Roland, Brusch, Lutz
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar Cells - cytology Adult Analysis Cell Count Cell Lineage Cell Size Cell Transdifferentiation Cellular Microenvironment Diabetes therapy Efficiency Gene expression Genetic engineering Homeostasis Humans Insulin-Secreting Cells - cytology Mathematical models Models, Biological Pancreas Rodents Signal Transduction System theory Transdifferentiation
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