Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies
Childhood asthma and obesity prevalence have increased in recent years suggesting a potential association. However, the direction of any association is poorly understood and the potential causal-relationship is unknown. We examined the association between overweight/obesity, defined by body mass ind...
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| Veröffentlicht in: | BMC pediatrics 2013-08, Vol.13 (1), p.121-121, Article 121 |
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| creator | Egan, Kathryn B Ettinger, Adrienne S Bracken, Michael B |
| description | Childhood asthma and obesity prevalence have increased in recent years suggesting a potential association. However, the direction of any association is poorly understood and the potential causal-relationship is unknown.
We examined the association between overweight/obesity, defined by body mass index (BMI) |
| doi_str_mv | 10.1186/1471-2431-13-121 |
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We examined the association between overweight/obesity, defined by body mass index (BMI) <18 years of age, and subsequent physician-diagnosed incident asthma at least one year after BMI assessment. We sought to explore potential effect modification by sex. PubMed and Embase were searched using keywords and restricted to subjects aged 0-18 years. There were no date or language restrictions. From each study we extracted: authors, publication date, location, overweight/obesity definitions, asthma definitions, number of participants, recruitment duration, description of cohort, follow-up time, adjusted effect estimates (with 95% CI) and estimates of subgroup analysis.
Six prospective cohort studies which focused on children <18 years of age met criteria for inclusion. The combined risk ratio (RR) of overweight was associated with asthma (RR = 1.35; 95% CI = 1.15, 1.58). In boys, the combined RR of overweight on asthma was significant (RR = 1.41; 95% CI = 1.05, 1.88). For girls, when BMI was defined by Z-score, the combined RR of overweight on asthma was also significant (RR = 1.19; 95% CI = 1.06, 1.34). The combined risk ratio (RR) of obesity was associated with asthma in both boys and girls (RR = 1.50; 95% CI = 1.22, 1.83), in boys only (RR = 1.40; 95% CI = 1.01, 1.93) and in girls only (RR = 1.53; 95% CI = 1.09, 2.14).
Overweight and, especially, obese children are at increased risk of subsequent physician diagnosed asthma in comparison to normal weight children. Except for sex, no studies reported any other potential effect modifiers. The observed sex effects were inconsistent.</description><identifier>ISSN: 1471-2431</identifier><identifier>EISSN: 1471-2431</identifier><identifier>DOI: 10.1186/1471-2431-13-121</identifier><identifier>PMID: 23941287</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Asthma ; Asthma - diagnosis ; Asthma - epidemiology ; Asthma - etiology ; Asthma in children ; Body Mass Index ; Body weight ; Child ; Children ; Children & youth ; Complications and side effects ; Diagnosis ; Epidemiology ; Female ; Follow-Up Studies ; Global Health ; Health aspects ; Humans ; Incidence ; Male ; Obesity ; Obesity - complications ; Obesity - diagnosis ; Obesity in children ; Physicians ; Prospective Studies ; Risk Factors ; Studies ; Teenagers</subject><ispartof>BMC pediatrics, 2013-08, Vol.13 (1), p.121-121, Article 121</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Egan et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Egan et al.; licensee BioMed Central Ltd. 2013 Egan et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b681t-c5d5d622ef3d44d0b321160af9bb6632f4c167e5cbdf30405d7339721dd9bfb53</citedby><cites>FETCH-LOGICAL-b681t-c5d5d622ef3d44d0b321160af9bb6632f4c167e5cbdf30405d7339721dd9bfb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751452/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751452/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23941287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Egan, Kathryn B</creatorcontrib><creatorcontrib>Ettinger, Adrienne S</creatorcontrib><creatorcontrib>Bracken, Michael B</creatorcontrib><title>Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies</title><title>BMC pediatrics</title><addtitle>BMC Pediatr</addtitle><description>Childhood asthma and obesity prevalence have increased in recent years suggesting a potential association. However, the direction of any association is poorly understood and the potential causal-relationship is unknown.
We examined the association between overweight/obesity, defined by body mass index (BMI) <18 years of age, and subsequent physician-diagnosed incident asthma at least one year after BMI assessment. We sought to explore potential effect modification by sex. PubMed and Embase were searched using keywords and restricted to subjects aged 0-18 years. There were no date or language restrictions. From each study we extracted: authors, publication date, location, overweight/obesity definitions, asthma definitions, number of participants, recruitment duration, description of cohort, follow-up time, adjusted effect estimates (with 95% CI) and estimates of subgroup analysis.
Six prospective cohort studies which focused on children <18 years of age met criteria for inclusion. The combined risk ratio (RR) of overweight was associated with asthma (RR = 1.35; 95% CI = 1.15, 1.58). In boys, the combined RR of overweight on asthma was significant (RR = 1.41; 95% CI = 1.05, 1.88). For girls, when BMI was defined by Z-score, the combined RR of overweight on asthma was also significant (RR = 1.19; 95% CI = 1.06, 1.34). The combined risk ratio (RR) of obesity was associated with asthma in both boys and girls (RR = 1.50; 95% CI = 1.22, 1.83), in boys only (RR = 1.40; 95% CI = 1.01, 1.93) and in girls only (RR = 1.53; 95% CI = 1.09, 2.14).
Overweight and, especially, obese children are at increased risk of subsequent physician diagnosed asthma in comparison to normal weight children. Except for sex, no studies reported any other potential effect modifiers. The observed sex effects were inconsistent.</description><subject>Asthma</subject><subject>Asthma - diagnosis</subject><subject>Asthma - epidemiology</subject><subject>Asthma - etiology</subject><subject>Asthma in children</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Child</subject><subject>Children</subject><subject>Children & youth</subject><subject>Complications and side effects</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Global Health</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - diagnosis</subject><subject>Obesity in children</subject><subject>Physicians</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Teenagers</subject><issn>1471-2431</issn><issn>1471-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkk2LFDEQhhtR3HX17kkCguyl185Xp9uDsAzrByx40XPIV09n6U7GrvTo_AN_tpmdcZiRFckhoep5XypVVRQvcXWFcVO_xUzgkjCKS0xLTPCj4vwQenz0PiueAdxVFRYNq58WZ4S2DJNGnBe_Fr0fbB-jRTraDRoVAPLBup9IBYtg1uC-zy4ktOo34I1XobReLUMEZ5GC1I_qHVIINpDcqJI3aHJr737cy0eXVKmCGrIUUOzQaoqwcib5tUMm9nFKCNJsvYPnxZNODeBe7O-L4tuHm6-LT-Xtl4-fF9e3pa4bnErDLbc1Ia6jljFbaUowrivVtVrXNSUdM7gWjhttO1qxiltBaSsItrbVneb0oni_813NenTW5K9NapCryY9q2siovDzNBN_LZVxLKjhmnGSDxc5A-_gPg9OMiaPcTkJuJyExlXlQ2eVyX8YUc38hydGDccOggoszSNy0ggracP5_lLMGt4wQkdHXf6F3cZ5y_zPFSN1wQu4N99RSDU760MVcp9maymtOWY0F422mrh6g8rFu9CYG1_kcPxG8ORL0Tg2phzjMyccAp2C1A03eBphcd2geruR2rx9q16vjqR0EfxaZ_gblAfPo</recordid><startdate>20130813</startdate><enddate>20130813</enddate><creator>Egan, Kathryn B</creator><creator>Ettinger, Adrienne S</creator><creator>Bracken, Michael B</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TS</scope><scope>5PM</scope></search><sort><creationdate>20130813</creationdate><title>Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies</title><author>Egan, Kathryn B ; Ettinger, Adrienne S ; Bracken, Michael B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b681t-c5d5d622ef3d44d0b321160af9bb6632f4c167e5cbdf30405d7339721dd9bfb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Asthma</topic><topic>Asthma - diagnosis</topic><topic>Asthma - epidemiology</topic><topic>Asthma - etiology</topic><topic>Asthma in children</topic><topic>Body Mass Index</topic><topic>Body weight</topic><topic>Child</topic><topic>Children</topic><topic>Children & youth</topic><topic>Complications and side effects</topic><topic>Diagnosis</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Global Health</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - diagnosis</topic><topic>Obesity in children</topic><topic>Physicians</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Egan, Kathryn B</creatorcontrib><creatorcontrib>Ettinger, Adrienne S</creatorcontrib><creatorcontrib>Bracken, Michael B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Egan, Kathryn B</au><au>Ettinger, Adrienne S</au><au>Bracken, Michael B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies</atitle><jtitle>BMC pediatrics</jtitle><addtitle>BMC Pediatr</addtitle><date>2013-08-13</date><risdate>2013</risdate><volume>13</volume><issue>1</issue><spage>121</spage><epage>121</epage><pages>121-121</pages><artnum>121</artnum><issn>1471-2431</issn><eissn>1471-2431</eissn><abstract>Childhood asthma and obesity prevalence have increased in recent years suggesting a potential association. However, the direction of any association is poorly understood and the potential causal-relationship is unknown.
We examined the association between overweight/obesity, defined by body mass index (BMI) <18 years of age, and subsequent physician-diagnosed incident asthma at least one year after BMI assessment. We sought to explore potential effect modification by sex. PubMed and Embase were searched using keywords and restricted to subjects aged 0-18 years. There were no date or language restrictions. From each study we extracted: authors, publication date, location, overweight/obesity definitions, asthma definitions, number of participants, recruitment duration, description of cohort, follow-up time, adjusted effect estimates (with 95% CI) and estimates of subgroup analysis.
Six prospective cohort studies which focused on children <18 years of age met criteria for inclusion. The combined risk ratio (RR) of overweight was associated with asthma (RR = 1.35; 95% CI = 1.15, 1.58). In boys, the combined RR of overweight on asthma was significant (RR = 1.41; 95% CI = 1.05, 1.88). For girls, when BMI was defined by Z-score, the combined RR of overweight on asthma was also significant (RR = 1.19; 95% CI = 1.06, 1.34). The combined risk ratio (RR) of obesity was associated with asthma in both boys and girls (RR = 1.50; 95% CI = 1.22, 1.83), in boys only (RR = 1.40; 95% CI = 1.01, 1.93) and in girls only (RR = 1.53; 95% CI = 1.09, 2.14).
Overweight and, especially, obese children are at increased risk of subsequent physician diagnosed asthma in comparison to normal weight children. Except for sex, no studies reported any other potential effect modifiers. The observed sex effects were inconsistent.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23941287</pmid><doi>10.1186/1471-2431-13-121</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Asthma Asthma - diagnosis Asthma - epidemiology Asthma - etiology Asthma in children Body Mass Index Body weight Child Children Children & youth Complications and side effects Diagnosis Epidemiology Female Follow-Up Studies Global Health Health aspects Humans Incidence Male Obesity Obesity - complications Obesity - diagnosis Obesity in children Physicians Prospective Studies Risk Factors Studies Teenagers |
| title | Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies |
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