17β-estradiol confers protection after traumatic brain injury in the rat and involves activation of G protein-coupled estrogen receptor 1

Abstract Traumatic brain injury (TBI) is a significant public health problem in the United States. Despite preclinical success of various drugs, to date all clinical trials investigating potential therapeutics have failed. Recently, sex steroid hormones have sparked interest as possible neuroprotect...

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Veröffentlicht in:	Journal of neurotrauma 2013-09, Vol.30 (17), p.1531-1541
Hauptverfasser:	Day, Nicole L, Floyd, Candace L, D'Alessandro, Tracy L, Hubbard, William J, Chaudry, Irshad H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Injuries - metabolism Brain Injuries - pathology Brain Injuries - prevention & control Cell Survival - drug effects Cell Survival - physiology Dose-Response Relationship, Drug Estradiol - pharmacology Estradiol - therapeutic use Male Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Original Rats Rats, Sprague-Dawley Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - metabolism
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