Airway transplantation: a challenge for regenerative medicine

After more than 50 years of research, airway transplantation remains a major challenge in the fields of thoracic surgery and regenerative medicine. Five principal types of tracheobronchial substitutes, including synthetic prostheses, bioprostheses, allografts, autografts and bioengineered conduits h...

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Veröffentlicht in:European journal of medical research 2013-07, Vol.18 (1), p.25-25, Article 25
Hauptverfasser: Martinod, Emmanuel, Seguin, Agathe, Radu, Dana M, Boddaert, Guillaume, Chouahnia, Kader, Fialaire-Legendre, Anne, Dutau, Hervé, Vénissac, Nicolas, Marquette, Charles-Hugo, Baillard, Christophe, Valeyre, Dominique, Carpentier, Alain
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container_issue 1
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container_title European journal of medical research
container_volume 18
creator Martinod, Emmanuel
Seguin, Agathe
Radu, Dana M
Boddaert, Guillaume
Chouahnia, Kader
Fialaire-Legendre, Anne
Dutau, Hervé
Vénissac, Nicolas
Marquette, Charles-Hugo
Baillard, Christophe
Valeyre, Dominique
Carpentier, Alain
description After more than 50 years of research, airway transplantation remains a major challenge in the fields of thoracic surgery and regenerative medicine. Five principal types of tracheobronchial substitutes, including synthetic prostheses, bioprostheses, allografts, autografts and bioengineered conduits have been evaluated experimentally in numerous studies. However, none of these works have provided a standardized technique for the replacement of the airways. More recently, few clinical attempts have offered encouraging results with ex vivo or stem cell-based engineered airways and tracheal allografts implanted after heterotopic revascularization. In 1997, we proposed a novel approach: the use of aortic grafts as a biological matrix for extensive airway reconstruction. In vivo regeneration of epithelium and cartilage were demonstrated in animal models. This led to the first human applications using cryopreserved aortic allografts that present key advantages because they are available in tissue banks and do not require immunosuppressive therapy. Favorable results obtained in pioneering cases have to be confirmed in larger series of patients with extensive tracheobronchial diseases.
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source MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; SpringerNature Journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals
subjects Animals
Aorta - physiology
Health aspects
Humans
Immunotherapy
Lung cancer
Physiological aspects
Regenerative Medicine
Review
Stem cells
Tissue Engineering
Tissue Scaffolds - chemistry
Trachea - transplantation
Transplantation of organs, tissues, etc
title Airway transplantation: a challenge for regenerative medicine
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