LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer
Background: Emerging evidence has demonstrated that lysine-specific demethylase 1 (LSD1) has an important role in many pathological processes of cancer cells, such as carcinogenesis, proliferation and metastasis. In this study, we characterised the role and molecular mechanisms of LSD1 in proliferat...
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| Veröffentlicht in: | British journal of cancer 2013-08, Vol.109 (4), p.994-1003 |
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| creator | Ding, J Zhang, Z-M Xia, Y Liao, G-Q Pan, Y Liu, S Zhang, Y Yan, Z-S |
| description | Background:
Emerging evidence has demonstrated that lysine-specific demethylase 1 (LSD1) has an important role in many pathological processes of cancer cells, such as carcinogenesis, proliferation and metastasis. In this study, we characterised the role and molecular mechanisms of LSD1 in proliferation and metastasis of colon cancer.
Methods:
We evaluated the correlation of LSD1, CDH-1 and CDH-2 with invasiveness of colon cancer cells, and investigated the roles of LSD1 in proliferation, invasion and apoptosis of colon cancer cells. We further investigated the mechanisms of LSD1-mediated metastasis of colon cancer.
Results:
Lysine-specific demethylase 1 was upregulated in colon cancer tissues, and the high LSD1 expression was significantly associated with tumour-node-metastasis (TNM) stages and distant metastasis. Functionally, inhibition of LSD1 impaired proliferation and invasiveness, and induced apoptosis of colon cancer cells
in vitro
. The LSD1 physically interacted with the promoter of
CDH-1
and decreased dimethyl histone H3 lysine 4 (H3K4) at this region, downregulated CDH-1 expression, and consequently contributed to colon cancer metastasis.
Conclusion:
Lysine-specific demethylase 1 downregulates the expression of CDH-1 by epigenetic modification, and consequently promotes metastasis of colon cancer cells. The LSD1 antagonists might be a useful strategy to suppress metastasis of colon cancer. |
| doi_str_mv | 10.1038/bjc.2013.364 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3749561</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3050248991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c480t-f265e94d496a349253ce552de4b310da89c8e4f0786a4ad41a5ae44a9704a8d3</originalsourceid><addsrcrecordid>eNptkc1rGzEUxEVISNw0t57DQsit6-hrd6VLoSRtEzDk0NzFs_TWlVmvHEku9L-vjB3XhYBAiPlp3khDyCdGp4wKdTdf2imnTExFK0_IhDWC10zx7pRMKKVdTTWnF-RDSsty1FR15-SCC00pZ82EwOznA6tX6DxkdBWu_QJHzN5Wq-B87y1kH8bKhjFHP99kTFUO1TqGwfcYdyKMrlphhlSWT1XoCz5sL8FoMX4kZz0MCa_2-yV5-f7t5f6xnj3_eLr_OqutVDTXPW8b1NJJ3YKQmjfCYtNwh3IuGHWgtFUoe9qpFiQ4yaABlBJ0RyUoJy7Jl53tejMvz7FYAsNg1tGvIP4xAbz5Xxn9L7MIv43opG5aVgxu9gYxvG4wZbMMmziWyIbJEk5oprbU5x1lY0gpYn-YwKjZ9mFKH2bbhyl9FPz6ONUBfiugALd7AJKFoY_lz3z6x3UtbzvdFq7ecalI4wLjUbr3Bv8FLb6j0A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1426539181</pqid></control><display><type>article</type><title>LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer</title><source>MEDLINE</source><source>SpringerLink_现刊</source><source>Single Title from Nature Journals</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><creator>Ding, J ; Zhang, Z-M ; Xia, Y ; Liao, G-Q ; Pan, Y ; Liu, S ; Zhang, Y ; Yan, Z-S</creator><creatorcontrib>Ding, J ; Zhang, Z-M ; Xia, Y ; Liao, G-Q ; Pan, Y ; Liu, S ; Zhang, Y ; Yan, Z-S</creatorcontrib><description>Background:
Emerging evidence has demonstrated that lysine-specific demethylase 1 (LSD1) has an important role in many pathological processes of cancer cells, such as carcinogenesis, proliferation and metastasis. In this study, we characterised the role and molecular mechanisms of LSD1 in proliferation and metastasis of colon cancer.
Methods:
We evaluated the correlation of LSD1, CDH-1 and CDH-2 with invasiveness of colon cancer cells, and investigated the roles of LSD1 in proliferation, invasion and apoptosis of colon cancer cells. We further investigated the mechanisms of LSD1-mediated metastasis of colon cancer.
Results:
Lysine-specific demethylase 1 was upregulated in colon cancer tissues, and the high LSD1 expression was significantly associated with tumour-node-metastasis (TNM) stages and distant metastasis. Functionally, inhibition of LSD1 impaired proliferation and invasiveness, and induced apoptosis of colon cancer cells
in vitro
. The LSD1 physically interacted with the promoter of
CDH-1
and decreased dimethyl histone H3 lysine 4 (H3K4) at this region, downregulated CDH-1 expression, and consequently contributed to colon cancer metastasis.
Conclusion:
Lysine-specific demethylase 1 downregulates the expression of CDH-1 by epigenetic modification, and consequently promotes metastasis of colon cancer cells. The LSD1 antagonists might be a useful strategy to suppress metastasis of colon cancer.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2013.364</identifier><identifier>PMID: 23900215</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/420/2489/2487/2486 ; 692/699/67/1504/1885/1393 ; 692/699/67/322 ; Antigens, CD - genetics ; Antigens, CD - physiology ; Apoptosis ; Apoptosis - genetics ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cadherins - genetics ; Cadherins - physiology ; Cancer Research ; Cell Line, Tumor ; Cell Proliferation ; Colonic Neoplasms - genetics ; Colonic Neoplasms - pathology ; Colorectal cancer ; Drug Resistance ; Epidemiology ; Epigenesis, Genetic ; Epigenetics ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal surgery ; Histone Demethylases - genetics ; Histone Demethylases - physiology ; Histones - metabolism ; HT29 Cells ; Humans ; Medical research ; Medical sciences ; Metastasis ; Molecular Diagnostics ; Molecular Medicine ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasm Invasiveness - genetics ; Oncology ; Reverse Transcriptase Polymerase Chain Reaction ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>British journal of cancer, 2013-08, Vol.109 (4), p.994-1003</ispartof><rights>The Author(s) 2013</rights><rights>2014 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Aug 20, 2013</rights><rights>Copyright © 2013 Cancer Research UK 2013 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-f265e94d496a349253ce552de4b310da89c8e4f0786a4ad41a5ae44a9704a8d3</citedby><cites>FETCH-LOGICAL-c480t-f265e94d496a349253ce552de4b310da89c8e4f0786a4ad41a5ae44a9704a8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749561/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749561/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27626796$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23900215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ding, J</creatorcontrib><creatorcontrib>Zhang, Z-M</creatorcontrib><creatorcontrib>Xia, Y</creatorcontrib><creatorcontrib>Liao, G-Q</creatorcontrib><creatorcontrib>Pan, Y</creatorcontrib><creatorcontrib>Liu, S</creatorcontrib><creatorcontrib>Zhang, Y</creatorcontrib><creatorcontrib>Yan, Z-S</creatorcontrib><title>LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Emerging evidence has demonstrated that lysine-specific demethylase 1 (LSD1) has an important role in many pathological processes of cancer cells, such as carcinogenesis, proliferation and metastasis. In this study, we characterised the role and molecular mechanisms of LSD1 in proliferation and metastasis of colon cancer.
Methods:
We evaluated the correlation of LSD1, CDH-1 and CDH-2 with invasiveness of colon cancer cells, and investigated the roles of LSD1 in proliferation, invasion and apoptosis of colon cancer cells. We further investigated the mechanisms of LSD1-mediated metastasis of colon cancer.
Results:
Lysine-specific demethylase 1 was upregulated in colon cancer tissues, and the high LSD1 expression was significantly associated with tumour-node-metastasis (TNM) stages and distant metastasis. Functionally, inhibition of LSD1 impaired proliferation and invasiveness, and induced apoptosis of colon cancer cells
in vitro
. The LSD1 physically interacted with the promoter of
CDH-1
and decreased dimethyl histone H3 lysine 4 (H3K4) at this region, downregulated CDH-1 expression, and consequently contributed to colon cancer metastasis.
Conclusion:
Lysine-specific demethylase 1 downregulates the expression of CDH-1 by epigenetic modification, and consequently promotes metastasis of colon cancer cells. The LSD1 antagonists might be a useful strategy to suppress metastasis of colon cancer.</description><subject>692/420/2489/2487/2486</subject><subject>692/699/67/1504/1885/1393</subject><subject>692/699/67/322</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - physiology</subject><subject>Apoptosis</subject><subject>Apoptosis - genetics</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cadherins - genetics</subject><subject>Cadherins - physiology</subject><subject>Cancer Research</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Colonic Neoplasms - genetics</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colorectal cancer</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal surgery</subject><subject>Histone Demethylases - genetics</subject><subject>Histone Demethylases - physiology</subject><subject>Histones - metabolism</subject><subject>HT29 Cells</subject><subject>Humans</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metastasis</subject><subject>Molecular Diagnostics</subject><subject>Molecular Medicine</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Oncology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkc1rGzEUxEVISNw0t57DQsit6-hrd6VLoSRtEzDk0NzFs_TWlVmvHEku9L-vjB3XhYBAiPlp3khDyCdGp4wKdTdf2imnTExFK0_IhDWC10zx7pRMKKVdTTWnF-RDSsty1FR15-SCC00pZ82EwOznA6tX6DxkdBWu_QJHzN5Wq-B87y1kH8bKhjFHP99kTFUO1TqGwfcYdyKMrlphhlSWT1XoCz5sL8FoMX4kZz0MCa_2-yV5-f7t5f6xnj3_eLr_OqutVDTXPW8b1NJJ3YKQmjfCYtNwh3IuGHWgtFUoe9qpFiQ4yaABlBJ0RyUoJy7Jl53tejMvz7FYAsNg1tGvIP4xAbz5Xxn9L7MIv43opG5aVgxu9gYxvG4wZbMMmziWyIbJEk5oprbU5x1lY0gpYn-YwKjZ9mFKH2bbhyl9FPz6ONUBfiugALd7AJKFoY_lz3z6x3UtbzvdFq7ecalI4wLjUbr3Bv8FLb6j0A</recordid><startdate>20130820</startdate><enddate>20130820</enddate><creator>Ding, J</creator><creator>Zhang, Z-M</creator><creator>Xia, Y</creator><creator>Liao, G-Q</creator><creator>Pan, Y</creator><creator>Liu, S</creator><creator>Zhang, Y</creator><creator>Yan, Z-S</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20130820</creationdate><title>LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer</title><author>Ding, J ; Zhang, Z-M ; Xia, Y ; Liao, G-Q ; Pan, Y ; Liu, S ; Zhang, Y ; Yan, Z-S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-f265e94d496a349253ce552de4b310da89c8e4f0786a4ad41a5ae44a9704a8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>692/420/2489/2487/2486</topic><topic>692/699/67/1504/1885/1393</topic><topic>692/699/67/322</topic><topic>Antigens, CD - genetics</topic><topic>Antigens, CD - physiology</topic><topic>Apoptosis</topic><topic>Apoptosis - genetics</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cadherins - genetics</topic><topic>Cadherins - physiology</topic><topic>Cancer Research</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Colonic Neoplasms - genetics</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colorectal cancer</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Gastroenterology. 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Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, J</creatorcontrib><creatorcontrib>Zhang, Z-M</creatorcontrib><creatorcontrib>Xia, Y</creatorcontrib><creatorcontrib>Liao, G-Q</creatorcontrib><creatorcontrib>Pan, Y</creatorcontrib><creatorcontrib>Liu, S</creatorcontrib><creatorcontrib>Zhang, Y</creatorcontrib><creatorcontrib>Yan, Z-S</creatorcontrib><collection>Springer_OA刊</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, J</au><au>Zhang, Z-M</au><au>Xia, Y</au><au>Liao, G-Q</au><au>Pan, Y</au><au>Liu, S</au><au>Zhang, Y</au><au>Yan, Z-S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2013-08-20</date><risdate>2013</risdate><volume>109</volume><issue>4</issue><spage>994</spage><epage>1003</epage><pages>994-1003</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Emerging evidence has demonstrated that lysine-specific demethylase 1 (LSD1) has an important role in many pathological processes of cancer cells, such as carcinogenesis, proliferation and metastasis. In this study, we characterised the role and molecular mechanisms of LSD1 in proliferation and metastasis of colon cancer.
Methods:
We evaluated the correlation of LSD1, CDH-1 and CDH-2 with invasiveness of colon cancer cells, and investigated the roles of LSD1 in proliferation, invasion and apoptosis of colon cancer cells. We further investigated the mechanisms of LSD1-mediated metastasis of colon cancer.
Results:
Lysine-specific demethylase 1 was upregulated in colon cancer tissues, and the high LSD1 expression was significantly associated with tumour-node-metastasis (TNM) stages and distant metastasis. Functionally, inhibition of LSD1 impaired proliferation and invasiveness, and induced apoptosis of colon cancer cells
in vitro
. The LSD1 physically interacted with the promoter of
CDH-1
and decreased dimethyl histone H3 lysine 4 (H3K4) at this region, downregulated CDH-1 expression, and consequently contributed to colon cancer metastasis.
Conclusion:
Lysine-specific demethylase 1 downregulates the expression of CDH-1 by epigenetic modification, and consequently promotes metastasis of colon cancer cells. The LSD1 antagonists might be a useful strategy to suppress metastasis of colon cancer.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23900215</pmid><doi>10.1038/bjc.2013.364</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/420/2489/2487/2486 692/699/67/1504/1885/1393 692/699/67/322 Antigens, CD - genetics Antigens, CD - physiology Apoptosis Apoptosis - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cadherins - genetics Cadherins - physiology Cancer Research Cell Line, Tumor Cell Proliferation Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colorectal cancer Drug Resistance Epidemiology Epigenesis, Genetic Epigenetics Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal surgery Histone Demethylases - genetics Histone Demethylases - physiology Histones - metabolism HT29 Cells Humans Medical research Medical sciences Metastasis Molecular Diagnostics Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Invasiveness - genetics Oncology Reverse Transcriptase Polymerase Chain Reaction Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer |
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