Elevated Mechanical Loading When Young Provides Lifelong Benefits to Cortical Bone Properties in Female Rats Independent of a Surgically Induced Menopause
Exercise that mechanically loads the skeleton is advocated when young to enhance lifelong bone health. Whether the skeletal benefits of elevated loading when young persist into adulthood and after menopause are important questions. This study investigated the influence of a surgically induced menopa...
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| Veröffentlicht in: | Endocrinology (Philadelphia) 2013-09, Vol.154 (9), p.3178-3187 |
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| creator | Warden, Stuart J Galley, Matthew R Hurd, Andrea L Wallace, Joseph M Gallant, Maxime A Richard, Jeffrey S George, Lydia A |
| description | Exercise that mechanically loads the skeleton is advocated when young to enhance lifelong bone health. Whether the skeletal benefits of elevated loading when young persist into adulthood and after menopause are important questions. This study investigated the influence of a surgically induced menopause in female Sprague-Dawley rats on the lifelong maintenance of the cortical bone benefits of skeletal loading when young. Animals had their right forearm extrinsically loaded 3 d/wk between 4 and 10 weeks of age using the forearm axial compression loading model. Left forearms were internal controls and not loaded. Animals were subsequently detrained (restricted to cage activities) for 94 weeks (until age 2 years), with ovariectomy (OVX) or sham-OVX surgery being performed at 24 weeks of age. Loading enhanced midshaft ulna cortical bone mass, structure, and estimated strength. These benefits persisted lifelong and contributed to loaded ulnas having greater strength after detraining. Loading also had effects on cortical bone quality. The benefits of loading when young were not influenced by a surgically induced menopause because there were no interactions between loading and surgery. However, OVX had independent effects on cortical bone mass, structure, and estimated strength at early postsurgery time points (up to age 58 weeks) and bone quality measures. These data indicate skeletal loading when young had lifelong benefits on cortical bone properties that persisted independent of a surgically induced menopause. This suggests that skeletal loading associated with exercise when young may provide lifelong antifracture benefits by priming the skeleton to offset the cortical bone changes associated with aging and menopause. |
| doi_str_mv | 10.1210/en.2013-1227 |
| format | Article |
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Whether the skeletal benefits of elevated loading when young persist into adulthood and after menopause are important questions. This study investigated the influence of a surgically induced menopause in female Sprague-Dawley rats on the lifelong maintenance of the cortical bone benefits of skeletal loading when young. Animals had their right forearm extrinsically loaded 3 d/wk between 4 and 10 weeks of age using the forearm axial compression loading model. Left forearms were internal controls and not loaded. Animals were subsequently detrained (restricted to cage activities) for 94 weeks (until age 2 years), with ovariectomy (OVX) or sham-OVX surgery being performed at 24 weeks of age. Loading enhanced midshaft ulna cortical bone mass, structure, and estimated strength. These benefits persisted lifelong and contributed to loaded ulnas having greater strength after detraining. Loading also had effects on cortical bone quality. The benefits of loading when young were not influenced by a surgically induced menopause because there were no interactions between loading and surgery. However, OVX had independent effects on cortical bone mass, structure, and estimated strength at early postsurgery time points (up to age 58 weeks) and bone quality measures. These data indicate skeletal loading when young had lifelong benefits on cortical bone properties that persisted independent of a surgically induced menopause. This suggests that skeletal loading associated with exercise when young may provide lifelong antifracture benefits by priming the skeleton to offset the cortical bone changes associated with aging and menopause.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.2013-1227</identifier><identifier>PMID: 23782938</identifier><identifier>CODEN: ENDOAO</identifier><language>eng</language><publisher>Chevy Chase, MD: Endocrine Society</publisher><subject>Age composition ; Aging ; Aging (artificial) ; Animals ; Biological and medical sciences ; Bone and Bones - chemistry ; Bone and Bones - diagnostic imaging ; Bone and Bones - pathology ; Bone Density ; Bone Development ; Bone mass ; Bone surgery ; Chemical Phenomena ; Compression loads ; Cortical bone ; Female ; Females ; Forearm ; Fundamental and applied biological sciences. Psychology ; General Endocrinology ; Humans ; Mechanical loading ; Mechanical Phenomena ; Menopause ; Motor Activity ; Osteoporosis, Postmenopausal - diagnostic imaging ; Osteoporosis, Postmenopausal - pathology ; Osteoporosis, Postmenopausal - prevention & control ; Ovariectomy ; Ovariectomy - adverse effects ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Skeleton ; Surgery ; Tomography, X-Ray Computed ; Ulna ; Ulna - chemistry ; Ulna - diagnostic imaging ; Ulna - growth & development ; Ulna - pathology ; Vertebrates: endocrinology ; Weight-Bearing</subject><ispartof>Endocrinology (Philadelphia), 2013-09, Vol.154 (9), p.3178-3187</ispartof><rights>Copyright © 2013 by The Endocrine Society</rights><rights>Copyright © 2013 by The Endocrine Society 2013</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-7b3460b4a19476ba516bd1941fdeb196d79ff15d9153c71bd174292222cd60ee3</citedby><cites>FETCH-LOGICAL-c551t-7b3460b4a19476ba516bd1941fdeb196d79ff15d9153c71bd174292222cd60ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27663278$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23782938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Warden, Stuart J</creatorcontrib><creatorcontrib>Galley, Matthew R</creatorcontrib><creatorcontrib>Hurd, Andrea L</creatorcontrib><creatorcontrib>Wallace, Joseph M</creatorcontrib><creatorcontrib>Gallant, Maxime A</creatorcontrib><creatorcontrib>Richard, Jeffrey S</creatorcontrib><creatorcontrib>George, Lydia A</creatorcontrib><title>Elevated Mechanical Loading When Young Provides Lifelong Benefits to Cortical Bone Properties in Female Rats Independent of a Surgically Induced Menopause</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>Exercise that mechanically loads the skeleton is advocated when young to enhance lifelong bone health. Whether the skeletal benefits of elevated loading when young persist into adulthood and after menopause are important questions. This study investigated the influence of a surgically induced menopause in female Sprague-Dawley rats on the lifelong maintenance of the cortical bone benefits of skeletal loading when young. Animals had their right forearm extrinsically loaded 3 d/wk between 4 and 10 weeks of age using the forearm axial compression loading model. Left forearms were internal controls and not loaded. Animals were subsequently detrained (restricted to cage activities) for 94 weeks (until age 2 years), with ovariectomy (OVX) or sham-OVX surgery being performed at 24 weeks of age. Loading enhanced midshaft ulna cortical bone mass, structure, and estimated strength. These benefits persisted lifelong and contributed to loaded ulnas having greater strength after detraining. Loading also had effects on cortical bone quality. The benefits of loading when young were not influenced by a surgically induced menopause because there were no interactions between loading and surgery. However, OVX had independent effects on cortical bone mass, structure, and estimated strength at early postsurgery time points (up to age 58 weeks) and bone quality measures. These data indicate skeletal loading when young had lifelong benefits on cortical bone properties that persisted independent of a surgically induced menopause. This suggests that skeletal loading associated with exercise when young may provide lifelong antifracture benefits by priming the skeleton to offset the cortical bone changes associated with aging and menopause.</description><subject>Age composition</subject><subject>Aging</subject><subject>Aging (artificial)</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - chemistry</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone and Bones - pathology</subject><subject>Bone Density</subject><subject>Bone Development</subject><subject>Bone mass</subject><subject>Bone surgery</subject><subject>Chemical Phenomena</subject><subject>Compression loads</subject><subject>Cortical bone</subject><subject>Female</subject><subject>Females</subject><subject>Forearm</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General Endocrinology</subject><subject>Humans</subject><subject>Mechanical loading</subject><subject>Mechanical Phenomena</subject><subject>Menopause</subject><subject>Motor Activity</subject><subject>Osteoporosis, Postmenopausal - diagnostic imaging</subject><subject>Osteoporosis, Postmenopausal - pathology</subject><subject>Osteoporosis, Postmenopausal - prevention & control</subject><subject>Ovariectomy</subject><subject>Ovariectomy - adverse effects</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Skeleton</subject><subject>Surgery</subject><subject>Tomography, X-Ray Computed</subject><subject>Ulna</subject><subject>Ulna - chemistry</subject><subject>Ulna - diagnostic imaging</subject><subject>Ulna - growth & development</subject><subject>Ulna - pathology</subject><subject>Vertebrates: endocrinology</subject><subject>Weight-Bearing</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkt2L1DAQwIMo3nn65rMERPTBns1Hm_ZF8JY7PVhR_EB8Cmk63c3RTWrSLty_4l_r9Ha9U1EwhGQy88t8JEPIQ5YfM87yF-CPec5ExjhXt8ghq2WRKaby2-Qwn_UK9QfkXkoXeJRSirvkgAtV8VpUh-T7aQ9bM0JL34JdG--s6ekymNb5Ff2yBk-_hgnF9zFsXQuJLl0HfUDNCXjo3JjoGOgixPHq5knwMLMDoAJp5-kZbEwP9INB9Ny3MAAufqSho4Z-nOJqvthfzrbJXuXhw2CmBPfJnc70CR7s9yPy-ez00-JNtnz3-nzxapnZomBjphohy7yRBitXZWMKVjYtyqxroWF12aq661jR1qwQVjG0KclrjsO2ZQ4gjsjLnd9hajbQWkwuml4P0W1MvNTBOP27xbu1XoWtFkrWspLo4NneQQzfJkij3rhkoe-NhzAlzUqGs-bsP1DJK644Okb08R_oRZiix5fQgom85LwSFVLPd5SNIaUI3XXeLNdzf2jweu4PPfcH4o9-rfUa_tkQCDzZAybhv3TReOvSDafKUnA1c093XJiGf4XM9iHFjsR_DzY6D0OElG6q-WuiPwD_5uD2</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Warden, Stuart J</creator><creator>Galley, Matthew R</creator><creator>Hurd, Andrea L</creator><creator>Wallace, Joseph M</creator><creator>Gallant, Maxime A</creator><creator>Richard, Jeffrey S</creator><creator>George, Lydia A</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130901</creationdate><title>Elevated Mechanical Loading When Young Provides Lifelong Benefits to Cortical Bone Properties in Female Rats Independent of a Surgically Induced Menopause</title><author>Warden, Stuart J ; Galley, Matthew R ; Hurd, Andrea L ; Wallace, Joseph M ; Gallant, Maxime A ; Richard, Jeffrey S ; George, Lydia A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-7b3460b4a19476ba516bd1941fdeb196d79ff15d9153c71bd174292222cd60ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age composition</topic><topic>Aging</topic><topic>Aging (artificial)</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - chemistry</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone and Bones - pathology</topic><topic>Bone Density</topic><topic>Bone Development</topic><topic>Bone mass</topic><topic>Bone surgery</topic><topic>Chemical Phenomena</topic><topic>Compression loads</topic><topic>Cortical bone</topic><topic>Female</topic><topic>Females</topic><topic>Forearm</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General Endocrinology</topic><topic>Humans</topic><topic>Mechanical loading</topic><topic>Mechanical Phenomena</topic><topic>Menopause</topic><topic>Motor Activity</topic><topic>Osteoporosis, Postmenopausal - diagnostic imaging</topic><topic>Osteoporosis, Postmenopausal - pathology</topic><topic>Osteoporosis, Postmenopausal - prevention & control</topic><topic>Ovariectomy</topic><topic>Ovariectomy - adverse effects</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Skeleton</topic><topic>Surgery</topic><topic>Tomography, X-Ray Computed</topic><topic>Ulna</topic><topic>Ulna - chemistry</topic><topic>Ulna - diagnostic imaging</topic><topic>Ulna - growth & development</topic><topic>Ulna - pathology</topic><topic>Vertebrates: endocrinology</topic><topic>Weight-Bearing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Warden, Stuart J</creatorcontrib><creatorcontrib>Galley, Matthew R</creatorcontrib><creatorcontrib>Hurd, Andrea L</creatorcontrib><creatorcontrib>Wallace, Joseph M</creatorcontrib><creatorcontrib>Gallant, Maxime A</creatorcontrib><creatorcontrib>Richard, Jeffrey S</creatorcontrib><creatorcontrib>George, Lydia A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Warden, Stuart J</au><au>Galley, Matthew R</au><au>Hurd, Andrea L</au><au>Wallace, Joseph M</au><au>Gallant, Maxime A</au><au>Richard, Jeffrey S</au><au>George, Lydia A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated Mechanical Loading When Young Provides Lifelong Benefits to Cortical Bone Properties in Female Rats Independent of a Surgically Induced Menopause</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>154</volume><issue>9</issue><spage>3178</spage><epage>3187</epage><pages>3178-3187</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><coden>ENDOAO</coden><abstract>Exercise that mechanically loads the skeleton is advocated when young to enhance lifelong bone health. Whether the skeletal benefits of elevated loading when young persist into adulthood and after menopause are important questions. This study investigated the influence of a surgically induced menopause in female Sprague-Dawley rats on the lifelong maintenance of the cortical bone benefits of skeletal loading when young. Animals had their right forearm extrinsically loaded 3 d/wk between 4 and 10 weeks of age using the forearm axial compression loading model. Left forearms were internal controls and not loaded. Animals were subsequently detrained (restricted to cage activities) for 94 weeks (until age 2 years), with ovariectomy (OVX) or sham-OVX surgery being performed at 24 weeks of age. Loading enhanced midshaft ulna cortical bone mass, structure, and estimated strength. These benefits persisted lifelong and contributed to loaded ulnas having greater strength after detraining. Loading also had effects on cortical bone quality. The benefits of loading when young were not influenced by a surgically induced menopause because there were no interactions between loading and surgery. However, OVX had independent effects on cortical bone mass, structure, and estimated strength at early postsurgery time points (up to age 58 weeks) and bone quality measures. These data indicate skeletal loading when young had lifelong benefits on cortical bone properties that persisted independent of a surgically induced menopause. This suggests that skeletal loading associated with exercise when young may provide lifelong antifracture benefits by priming the skeleton to offset the cortical bone changes associated with aging and menopause.</abstract><cop>Chevy Chase, MD</cop><pub>Endocrine Society</pub><pmid>23782938</pmid><doi>10.1210/en.2013-1227</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age composition Aging Aging (artificial) Animals Biological and medical sciences Bone and Bones - chemistry Bone and Bones - diagnostic imaging Bone and Bones - pathology Bone Density Bone Development Bone mass Bone surgery Chemical Phenomena Compression loads Cortical bone Female Females Forearm Fundamental and applied biological sciences. Psychology General Endocrinology Humans Mechanical loading Mechanical Phenomena Menopause Motor Activity Osteoporosis, Postmenopausal - diagnostic imaging Osteoporosis, Postmenopausal - pathology Osteoporosis, Postmenopausal - prevention & control Ovariectomy Ovariectomy - adverse effects Random Allocation Rats Rats, Sprague-Dawley Skeleton Surgery Tomography, X-Ray Computed Ulna Ulna - chemistry Ulna - diagnostic imaging Ulna - growth & development Ulna - pathology Vertebrates: endocrinology Weight-Bearing |
| title | Elevated Mechanical Loading When Young Provides Lifelong Benefits to Cortical Bone Properties in Female Rats Independent of a Surgically Induced Menopause |
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