Transforming Growth Factor-β―Induced Cross Talk Between p53 and a MicroRNA in the Pathogenesis of Diabetic Nephropathy

Elevated p53 expression is associated with several kidney diseases including diabetic nephropathy (DN). However, the mechanisms are unclear. We report that expression levels of transforming growth factor-β1 (TGF-β), p53, and microRNA-192 (miR-192) are increased in the renal cortex of diabetic mice,...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2013-09, Vol.62 (9), p.3151-3162
Hauptverfasser:	DESHPANDE, Supriya D, PUTTA, Sumanth, MEI WANG, LAI, Jennifer Y, BITZER, Markus, NELSON, Robert G, LANTING, Linda L, KATO, Mitsuo, NATARAJAN, Rama
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Associated diseases and complications Biological and medical sciences Blotting, Western Cells, Cultured Development and progression Diabetes. Impaired glucose tolerance Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic neuropathies Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Genetic aspects Immunohistochemistry Kidneys Medical sciences Mice Mice, Knockout Mice, Mutant Strains MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Nephrology. Urinary tract diseases Oligonucleotide Array Sequence Analysis Original Research Physiological aspects Reverse Transcriptase Polymerase Chain Reaction Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming growth factors Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Urinary system involvement in other diseases. Miscellaneous
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