Membrane association and destabilization by Aggregatibacter actinomycetemcomitans leukotoxin requires changes in secondary structures

Summary Aggregatibacter actinomycetemcomitans is a common inhabitant of the upper aerodigestive tract of humans and non‐human primates and is associated with disseminated infections, including lung and brain abscesses, pediatric infective endocarditis, and localized aggressive periodontitis. Aggrega...

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Veröffentlicht in:	Molecular oral microbiology 2013-10, Vol.28 (5), p.342-353
Hauptverfasser:	Walters, M.J., Brown, A.C., Edrington, T.C., Baranwal, S., Du, Y., Lally, E.T., Boesze-Battaglia, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregatibacter actinomycetemcomitans - metabolism Bacterial Toxins - chemistry Bacterial Toxins - metabolism Cell Death Cell Membrane - metabolism Circular Dichroism conformation Cytotoxins - chemistry Cytotoxins - metabolism Ethanolamines - chemistry Ethanolamines - metabolism Exotoxins - chemistry Exotoxins - metabolism Fluorescent Dyes Humans intrinsic disorder Jurkat Cells lipid membrane Liposomes Lymphocyte Function-Associated Antigen-1 - metabolism Lymphocytes - microbiology Lysophosphatidylcholines - chemistry Lysophosphatidylcholines - metabolism Naphthalenes Phosphatidylcholines Primates Protein Binding Protein Structure, Secondary Pyridinium Compounds Surface Plasmon Resonance unordered α-helix
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