Angiotensin II type 2 receptor (AT2R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons

Background The angiotensin II (AngII) receptor subtype 2 (AT2R) is expressed in sensory neurons and may play a role in nociception and neuronal regeneration. Methods We used immunostaining with characterized antibodies to study the localization of AT2R in cultured human and rat dorsal root ganglion...

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Veröffentlicht in:	European journal of pain 2013-08, Vol.17 (7), p.1012-1026
Hauptverfasser:	Anand, U., Facer, P., Yiangou, Y., Sinisi, M., Fox, M., McCarthy, T., Bountra, C., Korchev, Y.E., Anand, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Bromo Cyclic Adenosine Monophosphate - pharmacology Angiotensin II Type 2 Receptor Blockers - pharmacology Animals Benzhydryl Compounds - pharmacology Capsaicin - pharmacology Cells, Cultured Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Humans Isoquinolines - pharmacology Neurites - drug effects Neurites - metabolism Neurobiology Rats Receptor, Angiotensin, Type 2 - metabolism Sensory Receptor Cells - drug effects Sensory Receptor Cells - metabolism TRPV Cation Channels - drug effects TRPV Cation Channels - metabolism
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