Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy

BACKGROUND—Drug-coated balloons are increasingly used for peripheral vascular disease, and, yet, mechanisms of tissue uptake and retention remain poorly characterized. Most systems to date have used paclitaxel, touting its propensity to associate with various excipients that can optimize its transfe...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2013-05, Vol.127 (20), p.2047-2055
Hauptverfasser:	Kolachalama, Vijaya B, Pacetti, Stephen D, Franses, Joseph W, Stankus, John J, Zhao, Hugh Q, Shazly, Tarek, Nikanorov, Alexander, Schwartz, Lewis B, Tzafriri, Abraham R, Edelman, Elazer R
Format:	Artikel
Sprache:	eng
Schlagworte:	Angioplasty, Balloon - methods Animals Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Drug Delivery Systems - methods Female Femoral Artery - drug effects Femoral Artery - metabolism Male Medical sciences Organ Culture Techniques Paclitaxel - administration & dosage Paclitaxel - pharmacokinetics Sirolimus - administration & dosage Sirolimus - analogs & derivatives Sirolimus - pharmacokinetics Swine Tissue Distribution - drug effects Tissue Distribution - physiology
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