An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways

Cold allodynia elicited by local intraplantar injection of the chemotherapeutic agent oxaliplatin is mediated through Nav1.6-expressing peripheral sensory fibres. Activation of Nav1.6 alone elicits only mechanical allodynia and spontaneous pain, but when combined with inhibition of Kv channels, prof...

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Veröffentlicht in:	Pain (Amsterdam) 2013-09, Vol.154 (9), p.1749-1757
Hauptverfasser:	Deuis, Jennifer R., Zimmermann, Katharina, Romanovsky, Andrej A., Possani, Lourival D., Cabot, Peter J., Lewis, Richard J., Vetter, Irina
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - adverse effects Allodynia Analysis of Variance Animals Antineoplastic Agents - toxicity Biological and medical sciences Cold Temperature - adverse effects Disease Models, Animal Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Hyperalgesia - chemically induced Male Membrane Potentials - drug effects Membrane Potentials - genetics Mice Mice, Inbred C57BL Mice, Transgenic NAV1.3 Voltage-Gated Sodium Channel - genetics NAV1.3 Voltage-Gated Sodium Channel - metabolism NAV1.6 Voltage-Gated Sodium Channel - genetics NAV1.6 Voltage-Gated Sodium Channel - metabolism NAV1.9 Voltage-Gated Sodium Channel - genetics NAV1.9 Voltage-Gated Sodium Channel - metabolism Neuralgia - complications Neuralgia - genetics Organoplatinum Compounds - toxicity Oxaliplatin Potassium Channel Blockers - pharmacology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Transient Receptor Potential Channels - deficiency TRPA1 Cation Channel TRPM Cation Channels - deficiency Vertebrates: nervous system and sense organs Voltage-gated sodium channel
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