A new alpha in line between KRAS and NF-κB activation?

Bang and colleagues report a novel role for GSK-3α, rather than the well-studied GSK-3β, as the link between oncogenic KRAS and the canonical and noncanonical activation pathways of NF-κB in pancreatic cancer. Although the mechanism through which it promotes noncanonical activation remains unclear,...

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Veröffentlicht in:	Cancer discovery 2013-06, Vol.3 (6), p.613-615
Hauptverfasser:	Pak, Chorom, Miyamoto, Shigeki
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Glycogen Synthase Kinase 3 - metabolism Humans Molecular Targeted Therapy NF-kappa B - metabolism Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins p21(ras) ras Proteins - metabolism Signal Transduction
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