Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
Recent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function. We sought to identify novel lung function loci specifically for asthma and to confirm lung function loci identified in general populations. Genome-wide associ...
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| creator | Li, Xingnan Hawkins, Gregory A. Ampleford, Elizabeth J. Moore, Wendy C. Li, Huashi Hastie, Annette T. Howard, Timothy D. Boushey, Homer A. Busse, William W. Calhoun, William J. Castro, Mario Erzurum, Serpil C. Israel, Elliot Lemanske, Robert F. Szefler, Stanley J. Wasserman, Stephen I. Wenzel, Sally E. Peters, Stephen P. Meyers, Deborah A. Bleecker, Eugene R. |
| description | Recent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function.
We sought to identify novel lung function loci specifically for asthma and to confirm lung function loci identified in general populations.
Genome-wide association studies of lung function (percent predicted FEV1 [ppFEV1], percent predicted forced vital capacity, and FEV1/forced vital capacity ratio) were performed in 4 white populations of European descent (n = 1544), followed by meta-analyses.
Seven of 28 previously identified lung function loci (HHIP, FAM13A, THSD4, GSTCD, NOTCH4-AGER, RARB, and ZNF323) identified in general populations were confirmed at single nucleotide polymorphism (SNP) levels (P |
| doi_str_mv | 10.1016/j.jaci.2013.01.051 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3746327</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0091674913002613</els_id><sourcerecordid>1417531431</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4281-230a8a0e3341f658459023cbb25c5f13275b23ee8bbe3cc06d67eb537d684b8b3</originalsourceid><addsrcrecordid>eNp9kc1q3DAURkVpaSZpX6CLYiiFbOzq3zaUQAlpEgh0k66FLF_PyNjSVLIzzNtH7kzSNouuhKRzj-7Vh9AHgguCifzSF702tqCYsAKTAgvyCq0IrstcVlS8RiuMa5LLktcn6DTGHqc9q-q36IQywQmjfIXcNTg_Qr6zLWQ6Rm-snqx3WZzmdp-lUzfZzkLM7m9IttXTZqf32RpcOnnCoc12dtpkw-zWWTc781tgXQKmzZh0Zim0yRTfoTedHiK8P65n6Of3q_vLm_zux_Xt5be73HBakZwyrCuNgTFOOikqLmpMmWkaKozoUuelaCgDqJoGmDFYtrKERrCylRVvqoadoYuDdzs3I7QmvR30oLbBjjrslddW_Xvj7Eat_YNiJZdJnwTnR0Hwv2aIkxptNDAM2oGfoyKclIIRzkhCP71Aez8Hl8ZTRAhOa8kkThQ9UCb4GAN0z80QrJY4Va-WONUSp8JEpThT0ce_x3guecovAZ-PgI5GD13Qztj4hyslrqVYuK8HDtKnP1gIKpoUiIHWBjCTar39Xx-PlfG_Vg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1554296360</pqid></control><display><type>article</type><title>Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Li, Xingnan ; Hawkins, Gregory A. ; Ampleford, Elizabeth J. ; Moore, Wendy C. ; Li, Huashi ; Hastie, Annette T. ; Howard, Timothy D. ; Boushey, Homer A. ; Busse, William W. ; Calhoun, William J. ; Castro, Mario ; Erzurum, Serpil C. ; Israel, Elliot ; Lemanske, Robert F. ; Szefler, Stanley J. ; Wasserman, Stephen I. ; Wenzel, Sally E. ; Peters, Stephen P. ; Meyers, Deborah A. ; Bleecker, Eugene R.</creator><creatorcontrib>Li, Xingnan ; Hawkins, Gregory A. ; Ampleford, Elizabeth J. ; Moore, Wendy C. ; Li, Huashi ; Hastie, Annette T. ; Howard, Timothy D. ; Boushey, Homer A. ; Busse, William W. ; Calhoun, William J. ; Castro, Mario ; Erzurum, Serpil C. ; Israel, Elliot ; Lemanske, Robert F. ; Szefler, Stanley J. ; Wasserman, Stephen I. ; Wenzel, Sally E. ; Peters, Stephen P. ; Meyers, Deborah A. ; Bleecker, Eugene R.</creatorcontrib><description>Recent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function.
We sought to identify novel lung function loci specifically for asthma and to confirm lung function loci identified in general populations.
Genome-wide association studies of lung function (percent predicted FEV1 [ppFEV1], percent predicted forced vital capacity, and FEV1/forced vital capacity ratio) were performed in 4 white populations of European descent (n = 1544), followed by meta-analyses.
Seven of 28 previously identified lung function loci (HHIP, FAM13A, THSD4, GSTCD, NOTCH4-AGER, RARB, and ZNF323) identified in general populations were confirmed at single nucleotide polymorphism (SNP) levels (P < .05). Four of 32 loci (IL12A, IL12RB1, STAT4, and IRF2) associated with ppFEV1 (P < 10−4) belong to the TH1 or IL-12 cytokine family pathway. By using a linear additive model, these 4 TH1 pathway SNPs cumulatively explained 2.9% to 7.8% of the variance in ppFEV1 values in 4 populations (P = 3 × 10−11). Genetic scores of these 4 SNPs were associated with ppFEV1 values (P = 2 × 10−7) and the American Thoracic Society severe asthma classification (P = .005) in the Severe Asthma Research Program population. TH2 pathway genes (IL13, TSLP, IL33, and IL1RL1) conferring asthma susceptibility were not associated with lung function.
Genes involved in airway structure/remodeling are associated with lung function in both general populations and asthmatic subjects. TH1 pathway genes involved in anti-virus/bacterial infection and inflammation modify lung function in asthmatic subjects. Genes associated with lung function that might affect asthma severity are distinct from those genes associated with asthma susceptibility.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2013.01.051</identifier><identifier>PMID: 23541324</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Asthma ; Asthma - genetics ; Asthma - metabolism ; Asthma - physiopathology ; Biological and medical sciences ; Female ; FEV1 ; Forced Expiratory Volume - genetics ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genome-Wide Association Study ; Genomes ; Humans ; IL12A ; IL12RB1 ; Interferon Regulatory Factor-2 - genetics ; Interferon Regulatory Factor-2 - metabolism ; Interleukin-12 - genetics ; Interleukin-12 - metabolism ; IRF2 ; Lung - metabolism ; Lung - physiopathology ; Lung function ; Male ; Medical sciences ; Polymorphism, Single Nucleotide ; Quality control ; Respiratory Function Tests ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; STAT4 ; STAT4 Transcription Factor - genetics ; STAT4 Transcription Factor - metabolism ; Studies ; TH1 ; Th1 Cells - immunology ; Th1 Cells - metabolism ; Vital Capacity - genetics</subject><ispartof>Journal of allergy and clinical immunology, 2013-08, Vol.132 (2), p.313-320.e15</ispartof><rights>2013 American Academy of Allergy, Asthma & Immunology</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Aug 2013</rights><rights>2013 American Academy of Allergy, Asthma & Immunology 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4281-230a8a0e3341f658459023cbb25c5f13275b23ee8bbe3cc06d67eb537d684b8b3</citedby><cites>FETCH-LOGICAL-c4281-230a8a0e3341f658459023cbb25c5f13275b23ee8bbe3cc06d67eb537d684b8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091674913002613$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27609654$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23541324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xingnan</creatorcontrib><creatorcontrib>Hawkins, Gregory A.</creatorcontrib><creatorcontrib>Ampleford, Elizabeth J.</creatorcontrib><creatorcontrib>Moore, Wendy C.</creatorcontrib><creatorcontrib>Li, Huashi</creatorcontrib><creatorcontrib>Hastie, Annette T.</creatorcontrib><creatorcontrib>Howard, Timothy D.</creatorcontrib><creatorcontrib>Boushey, Homer A.</creatorcontrib><creatorcontrib>Busse, William W.</creatorcontrib><creatorcontrib>Calhoun, William J.</creatorcontrib><creatorcontrib>Castro, Mario</creatorcontrib><creatorcontrib>Erzurum, Serpil C.</creatorcontrib><creatorcontrib>Israel, Elliot</creatorcontrib><creatorcontrib>Lemanske, Robert F.</creatorcontrib><creatorcontrib>Szefler, Stanley J.</creatorcontrib><creatorcontrib>Wasserman, Stephen I.</creatorcontrib><creatorcontrib>Wenzel, Sally E.</creatorcontrib><creatorcontrib>Peters, Stephen P.</creatorcontrib><creatorcontrib>Meyers, Deborah A.</creatorcontrib><creatorcontrib>Bleecker, Eugene R.</creatorcontrib><title>Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Recent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function.
We sought to identify novel lung function loci specifically for asthma and to confirm lung function loci identified in general populations.
Genome-wide association studies of lung function (percent predicted FEV1 [ppFEV1], percent predicted forced vital capacity, and FEV1/forced vital capacity ratio) were performed in 4 white populations of European descent (n = 1544), followed by meta-analyses.
Seven of 28 previously identified lung function loci (HHIP, FAM13A, THSD4, GSTCD, NOTCH4-AGER, RARB, and ZNF323) identified in general populations were confirmed at single nucleotide polymorphism (SNP) levels (P < .05). Four of 32 loci (IL12A, IL12RB1, STAT4, and IRF2) associated with ppFEV1 (P < 10−4) belong to the TH1 or IL-12 cytokine family pathway. By using a linear additive model, these 4 TH1 pathway SNPs cumulatively explained 2.9% to 7.8% of the variance in ppFEV1 values in 4 populations (P = 3 × 10−11). Genetic scores of these 4 SNPs were associated with ppFEV1 values (P = 2 × 10−7) and the American Thoracic Society severe asthma classification (P = .005) in the Severe Asthma Research Program population. TH2 pathway genes (IL13, TSLP, IL33, and IL1RL1) conferring asthma susceptibility were not associated with lung function.
Genes involved in airway structure/remodeling are associated with lung function in both general populations and asthmatic subjects. TH1 pathway genes involved in anti-virus/bacterial infection and inflammation modify lung function in asthmatic subjects. Genes associated with lung function that might affect asthma severity are distinct from those genes associated with asthma susceptibility.</description><subject>Asthma</subject><subject>Asthma - genetics</subject><subject>Asthma - metabolism</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>FEV1</subject><subject>Forced Expiratory Volume - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Humans</subject><subject>IL12A</subject><subject>IL12RB1</subject><subject>Interferon Regulatory Factor-2 - genetics</subject><subject>Interferon Regulatory Factor-2 - metabolism</subject><subject>Interleukin-12 - genetics</subject><subject>Interleukin-12 - metabolism</subject><subject>IRF2</subject><subject>Lung - metabolism</subject><subject>Lung - physiopathology</subject><subject>Lung function</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Quality control</subject><subject>Respiratory Function Tests</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>STAT4</subject><subject>STAT4 Transcription Factor - genetics</subject><subject>STAT4 Transcription Factor - metabolism</subject><subject>Studies</subject><subject>TH1</subject><subject>Th1 Cells - immunology</subject><subject>Th1 Cells - metabolism</subject><subject>Vital Capacity - genetics</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1q3DAURkVpaSZpX6CLYiiFbOzq3zaUQAlpEgh0k66FLF_PyNjSVLIzzNtH7kzSNouuhKRzj-7Vh9AHgguCifzSF702tqCYsAKTAgvyCq0IrstcVlS8RiuMa5LLktcn6DTGHqc9q-q36IQywQmjfIXcNTg_Qr6zLWQ6Rm-snqx3WZzmdp-lUzfZzkLM7m9IttXTZqf32RpcOnnCoc12dtpkw-zWWTc781tgXQKmzZh0Zim0yRTfoTedHiK8P65n6Of3q_vLm_zux_Xt5be73HBakZwyrCuNgTFOOikqLmpMmWkaKozoUuelaCgDqJoGmDFYtrKERrCylRVvqoadoYuDdzs3I7QmvR30oLbBjjrslddW_Xvj7Eat_YNiJZdJnwTnR0Hwv2aIkxptNDAM2oGfoyKclIIRzkhCP71Aez8Hl8ZTRAhOa8kkThQ9UCb4GAN0z80QrJY4Va-WONUSp8JEpThT0ce_x3guecovAZ-PgI5GD13Qztj4hyslrqVYuK8HDtKnP1gIKpoUiIHWBjCTar39Xx-PlfG_Vg</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Li, Xingnan</creator><creator>Hawkins, Gregory A.</creator><creator>Ampleford, Elizabeth J.</creator><creator>Moore, Wendy C.</creator><creator>Li, Huashi</creator><creator>Hastie, Annette T.</creator><creator>Howard, Timothy D.</creator><creator>Boushey, Homer A.</creator><creator>Busse, William W.</creator><creator>Calhoun, William J.</creator><creator>Castro, Mario</creator><creator>Erzurum, Serpil C.</creator><creator>Israel, Elliot</creator><creator>Lemanske, Robert F.</creator><creator>Szefler, Stanley J.</creator><creator>Wasserman, Stephen I.</creator><creator>Wenzel, Sally E.</creator><creator>Peters, Stephen P.</creator><creator>Meyers, Deborah A.</creator><creator>Bleecker, Eugene R.</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201308</creationdate><title>Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients</title><author>Li, Xingnan ; Hawkins, Gregory A. ; Ampleford, Elizabeth J. ; Moore, Wendy C. ; Li, Huashi ; Hastie, Annette T. ; Howard, Timothy D. ; Boushey, Homer A. ; Busse, William W. ; Calhoun, William J. ; Castro, Mario ; Erzurum, Serpil C. ; Israel, Elliot ; Lemanske, Robert F. ; Szefler, Stanley J. ; Wasserman, Stephen I. ; Wenzel, Sally E. ; Peters, Stephen P. ; Meyers, Deborah A. ; Bleecker, Eugene R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4281-230a8a0e3341f658459023cbb25c5f13275b23ee8bbe3cc06d67eb537d684b8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Asthma</topic><topic>Asthma - genetics</topic><topic>Asthma - metabolism</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>FEV1</topic><topic>Forced Expiratory Volume - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>Humans</topic><topic>IL12A</topic><topic>IL12RB1</topic><topic>Interferon Regulatory Factor-2 - genetics</topic><topic>Interferon Regulatory Factor-2 - metabolism</topic><topic>Interleukin-12 - genetics</topic><topic>Interleukin-12 - metabolism</topic><topic>IRF2</topic><topic>Lung - metabolism</topic><topic>Lung - physiopathology</topic><topic>Lung function</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Quality control</topic><topic>Respiratory Function Tests</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>STAT4</topic><topic>STAT4 Transcription Factor - genetics</topic><topic>STAT4 Transcription Factor - metabolism</topic><topic>Studies</topic><topic>TH1</topic><topic>Th1 Cells - immunology</topic><topic>Th1 Cells - metabolism</topic><topic>Vital Capacity - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xingnan</creatorcontrib><creatorcontrib>Hawkins, Gregory A.</creatorcontrib><creatorcontrib>Ampleford, Elizabeth J.</creatorcontrib><creatorcontrib>Moore, Wendy C.</creatorcontrib><creatorcontrib>Li, Huashi</creatorcontrib><creatorcontrib>Hastie, Annette T.</creatorcontrib><creatorcontrib>Howard, Timothy D.</creatorcontrib><creatorcontrib>Boushey, Homer A.</creatorcontrib><creatorcontrib>Busse, William W.</creatorcontrib><creatorcontrib>Calhoun, William J.</creatorcontrib><creatorcontrib>Castro, Mario</creatorcontrib><creatorcontrib>Erzurum, Serpil C.</creatorcontrib><creatorcontrib>Israel, Elliot</creatorcontrib><creatorcontrib>Lemanske, Robert F.</creatorcontrib><creatorcontrib>Szefler, Stanley J.</creatorcontrib><creatorcontrib>Wasserman, Stephen I.</creatorcontrib><creatorcontrib>Wenzel, Sally E.</creatorcontrib><creatorcontrib>Peters, Stephen P.</creatorcontrib><creatorcontrib>Meyers, Deborah A.</creatorcontrib><creatorcontrib>Bleecker, Eugene R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xingnan</au><au>Hawkins, Gregory A.</au><au>Ampleford, Elizabeth J.</au><au>Moore, Wendy C.</au><au>Li, Huashi</au><au>Hastie, Annette T.</au><au>Howard, Timothy D.</au><au>Boushey, Homer A.</au><au>Busse, William W.</au><au>Calhoun, William J.</au><au>Castro, Mario</au><au>Erzurum, Serpil C.</au><au>Israel, Elliot</au><au>Lemanske, Robert F.</au><au>Szefler, Stanley J.</au><au>Wasserman, Stephen I.</au><au>Wenzel, Sally E.</au><au>Peters, Stephen P.</au><au>Meyers, Deborah A.</au><au>Bleecker, Eugene R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2013-08</date><risdate>2013</risdate><volume>132</volume><issue>2</issue><spage>313</spage><epage>320.e15</epage><pages>313-320.e15</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Recent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function.
We sought to identify novel lung function loci specifically for asthma and to confirm lung function loci identified in general populations.
Genome-wide association studies of lung function (percent predicted FEV1 [ppFEV1], percent predicted forced vital capacity, and FEV1/forced vital capacity ratio) were performed in 4 white populations of European descent (n = 1544), followed by meta-analyses.
Seven of 28 previously identified lung function loci (HHIP, FAM13A, THSD4, GSTCD, NOTCH4-AGER, RARB, and ZNF323) identified in general populations were confirmed at single nucleotide polymorphism (SNP) levels (P < .05). Four of 32 loci (IL12A, IL12RB1, STAT4, and IRF2) associated with ppFEV1 (P < 10−4) belong to the TH1 or IL-12 cytokine family pathway. By using a linear additive model, these 4 TH1 pathway SNPs cumulatively explained 2.9% to 7.8% of the variance in ppFEV1 values in 4 populations (P = 3 × 10−11). Genetic scores of these 4 SNPs were associated with ppFEV1 values (P = 2 × 10−7) and the American Thoracic Society severe asthma classification (P = .005) in the Severe Asthma Research Program population. TH2 pathway genes (IL13, TSLP, IL33, and IL1RL1) conferring asthma susceptibility were not associated with lung function.
Genes involved in airway structure/remodeling are associated with lung function in both general populations and asthmatic subjects. TH1 pathway genes involved in anti-virus/bacterial infection and inflammation modify lung function in asthmatic subjects. Genes associated with lung function that might affect asthma severity are distinct from those genes associated with asthma susceptibility.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>23541324</pmid><doi>10.1016/j.jaci.2013.01.051</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0091-6749 1097-6825 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Asthma Asthma - genetics Asthma - metabolism Asthma - physiopathology Biological and medical sciences Female FEV1 Forced Expiratory Volume - genetics Fundamental and applied biological sciences. Psychology Fundamental immunology Genome-Wide Association Study Genomes Humans IL12A IL12RB1 Interferon Regulatory Factor-2 - genetics Interferon Regulatory Factor-2 - metabolism Interleukin-12 - genetics Interleukin-12 - metabolism IRF2 Lung - metabolism Lung - physiopathology Lung function Male Medical sciences Polymorphism, Single Nucleotide Quality control Respiratory Function Tests Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis STAT4 STAT4 Transcription Factor - genetics STAT4 Transcription Factor - metabolism Studies TH1 Th1 Cells - immunology Th1 Cells - metabolism Vital Capacity - genetics |
| title | Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients |
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