A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal

Embryonic stem (ES) cell self‐renewal efficiency is determined by the Nanog protein level. However, the protein partners of Nanog that function to direct self‐renewal are unclear. Here, we identify a Nanog interactome of over 130 proteins including transcription factors, chromatin modifying complexe...

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Veröffentlicht in:	The EMBO journal 2013-08, Vol.32 (16), p.2231-2247
Hauptverfasser:	Gagliardi, Alessia, Mullin, Nicholas P, Ying Tan, Zi, Colby, Douglas, Kousa, Anastasia I, Halbritter, Florian, Weiss, Jason T, Felker, Anastasia, Bezstarosti, Karel, Favaro, Rebecca, Demmers, Jeroen, Nicolis, Silvia K, Tomlinson, Simon R, Poot, Raymond A, Chambers, Ian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell differentiation Cell Proliferation Colony-Forming Units Assay Deoxyribonucleic acid DNA DNA-independent interaction EMBO11 EMBO37 Embryonic Stem Cells - metabolism Embryonic Stem Cells - physiology Homeodomain Proteins - metabolism hydrophobic stacking Immunoblotting Immunoprecipitation Mice Molecular biology Mutation Nanog Homeobox Protein Plasmids - genetics pluripotency Protein Interaction Domains and Motifs - genetics Protein Interaction Mapping protein interactome Proteins SELEX SELEX Aptamer Technique Signal transduction SOXB1 Transcription Factors - metabolism Stem cells Tryptophan - metabolism Tyrosine - metabolism
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