Genetics of type 2 diabetes
Type 2 diabetes(T2D) is the result of interaction between environmental factors and a strong hereditary component.We review the heritability of T2D as well as the history of genetic and genomic research in this area.Very few T2D risk genes were identified using candidate gene and linkage-based studi...
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| Veröffentlicht in: | World journal of diabetes 2013-08, Vol.4 (4), p.114-123 |
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| container_title | World journal of diabetes |
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| creator | Ali, Omar |
| description | Type 2 diabetes(T2D) is the result of interaction between environmental factors and a strong hereditary component.We review the heritability of T2D as well as the history of genetic and genomic research in this area.Very few T2D risk genes were identified using candidate gene and linkage-based studies,but the advent of genome-wide association studies has led to the identification of multiple genes,including several that were not previously known to play any role in T2D.Highly replicated genes,for example TCF7L2,KCNQ1 and KCNJ11,are discussed in greater detail.Taken together,the genetic loci discovered to date explain only a small proportion of the observed heritability.We discuss possible explanations for this "missing heritability",including the role of rare variants,gene-environment interactions and epigenetics.The clinical utility of current findings and avenues of future research are also discussed. |
| doi_str_mv | 10.4239/wjd.v4.i4.114 |
| format | Article |
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| identifier | ISSN: 1948-9358 |
| ispartof | World journal of diabetes, 2013-08, Vol.4 (4), p.114-123 |
| issn | 1948-9358 1948-9358 |
| language | eng |
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| source | Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | association diabetes Genetics Genome-wide Heritability Minireviews studies TCF7L2 Type |
| title | Genetics of type 2 diabetes |
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