flavonoid luteolin induces nitric oxide production and arterial relaxation

PURPOSE: Luteolin, a flavone present in many foods and medicinal plants, may have beneficial effects on various human chronic diseases. In the present study, we investigated the hypothesis that luteolin can directly act on vascular endothelial cells (ECs), leading to nitric oxide (NO) production and...

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Veröffentlicht in:	European journal of nutrition 2014-02, Vol.53 (1), p.269-275
Hauptverfasser:	Si, Hongwei, Wyeth, Richard P, Liu, Dongmin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - cytology Aorta - drug effects Aorta - metabolism Arginine - administration & dosage Arginine - adverse effects Arginine - analogs & derivatives Biological and medical sciences Chemistry Chemistry and Materials Science chronic diseases Dose-Response Relationship, Drug endothelial cells Endothelial Cells - drug effects Feeding. Feeding behavior fluorometry functional foods Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques luteolin Luteolin - pharmacology Male medicinal plants nitric oxide Nitric Oxide - metabolism nitric oxide synthase Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Nutrition Original Contribution phenylephrine Phenylephrine - pharmacology Phosphorylation potassium Rats Rats, Sprague-Dawley vasodilation Vasodilation - drug effects Vertebrates: anatomy and physiology, studies on body, several organs or systems Western blotting
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