Burkholderia oklahomensis agglutinin is a canonical two‐domain OAA‐family lectin: structures, carbohydrate binding and anti‐HIV activity

Burkholderia oklahomensis EO147 agglutinin (BOA) is a 29 kDa member of the Oscillatoria agardhii agglutinin (OAA) family of lectins. Members of the OAA family recognize high‐mannose glycans, and, by binding to the HIV envelope glycoprotein 120 (gp120), block the virus from binding to and entering th...

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Veröffentlicht in:	FEBS J 2013-05, Vol.280 (9), p.2056-2067
Hauptverfasser:	Whitley, Matthew J., Furey, William, Kollipara, Sireesha, Gronenborn, Angela M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglutinins - chemistry Agglutinins - pharmacology Amino Acid Sequence Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology anti‐HIV activity Bacterial Proteins - chemistry Bacterial Proteins - pharmacology Binding Sites Burkholderia Carbohydrate Conformation Carbohydrate Sequence Carbohydrates Cell Line Conserved Sequence Crystallography, X-Ray high‐mannose glycans HIV HIV-1 - drug effects HIV-1 - physiology Human immunodeficiency virus Humans Hydrogen Bonding Inhibitory Concentration 50 lectins Mannans - chemistry Mannose-Binding Lectins - chemistry Mannose-Binding Lectins - pharmacology Models, Molecular Molecular Sequence Data NMR Nuclear Magnetic Resonance, Biomolecular Oscillatoria agardhii Protein Binding Protein Structure, Secondary Protein Structure, Tertiary X‐ray crystallography
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