MELK‐Dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells

Glioblastoma multiforme (GBM) is a life‐threatening brain tumor. Accumulating evidence suggests that eradication of glioma stem‐like cells (GSCs) in GBM is essential to achieve cure. The transcription factor FOXM1 has recently gained attention as a master regulator of mitotic progression of cancer c...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2013-06, Vol.31 (6), p.1051-1063
Hauptverfasser:	Joshi, Kaushal, Banasavadi‐Siddegowda, Yeshavanth, Mo, Xiaokui, Kim, Sung‐Hak, Mao, Ping, Kig, Cenk, Nardini, Diana, Sobol, Robert W., Chow, Lionel M.L., Kornblum, Harley I., Waclaw, Ronald, Beullens, Monique, Nakano, Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Cancer stem cell Cancer Stem Cells Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Proliferation - drug effects Cells, Cultured Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Glioblastoma Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma stem cell HEK293 Cells Humans Kinases Mice Mitosis - drug effects Mitosis - genetics Mitosis - physiology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Neural stem cell Neural Stem Cells - drug effects Neural Stem Cells - metabolism Neural Stem Cells - pathology Peptides - pharmacology Phosphorylation PLK1 Polo-Like Kinase 1 Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Stem cells Temozolomide Up-Regulation - drug effects
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