Tango7 directs cellular remodeling by the Drosophila apoptosome
It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collab...
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| Veröffentlicht in: | Genes & development 2013-08, Vol.27 (15), p.1650-1655 |
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| creator | D'Brot, Alejandro Chen, Po Vaishnav, Mahesh Yuan, Shujun Akey, Christopher W Abrams, John M |
| description | It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Drosophila apoptosome to drive a caspase-dependent remodeling process needed to resolve individual sperm from a syncytium. In these cells, Tango7 is required for caspase activity and localizes to the active apoptosome compartment via its C terminus. Furthermore, Tango7 directly stimulates the activity of this complex in vitro. We propose that Tango7 specifies the Drosophila apoptosome as an effector of cellular remodeling. |
| doi_str_mv | 10.1101/gad.219287.113 |
| format | Article |
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However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Drosophila apoptosome to drive a caspase-dependent remodeling process needed to resolve individual sperm from a syncytium. In these cells, Tango7 is required for caspase activity and localizes to the active apoptosome compartment via its C terminus. Furthermore, Tango7 directly stimulates the activity of this complex in vitro. 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We propose that Tango7 specifies the Drosophila apoptosome as an effector of cellular remodeling.</description><subject>Animals</subject><subject>Apoptosomes - metabolism</subject><subject>Aryl Hydrocarbon Receptor Nuclear Translocator - genetics</subject><subject>Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism</subject><subject>Caspases - metabolism</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - cytology</subject><subject>Drosophila melanogaster - enzymology</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Fertility - genetics</subject><subject>Genetic Variation</subject><subject>Male</subject><subject>Mutation</subject><subject>Research Communication</subject><subject>Spermatogenesis - genetics</subject><subject>Spermatozoa - enzymology</subject><subject>Spermatozoa - metabolism</subject><issn>0890-9369</issn><issn>1549-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUT1PwzAQtRCIlsLKiDKypNixE9sLCJVPqRJLmS3HuaZBSRzsBKn_HkctFWwsd3q6d0_37iF0SfCcEExuSl3MEyITwQOmR2hKUibjlHF-jKZYSBxLmskJOvP-A2Oc4Sw7RZOESkJlgqfobqXb0vKoqByY3kcG6nqotYscNLaAumrLKN9G_QaiB2e97TZVrSPd2a4PqIFzdLLWtYeLfZ-h96fH1eIlXr49vy7ul7FhQvax4YaDXHNIADhNcyCSGClwqHmWrw0YaYAKJqWgJMsEFFQXeaKxYQGznM7Q7U63G_IGCgNt73StOlc12m2V1ZX6O2mrjSrtl6KcMZ7QIHC9F3D2cwDfq6byo1vdgh28IowyTFNCkn9QiSBMUD6qzndUE57jHawPFxGsxoBUCEjtAgp4XLj67eNA_0mEfgPcGY0O</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>D'Brot, Alejandro</creator><creator>Chen, Po</creator><creator>Vaishnav, Mahesh</creator><creator>Yuan, Shujun</creator><creator>Akey, Christopher W</creator><creator>Abrams, John M</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20130801</creationdate><title>Tango7 directs cellular remodeling by the Drosophila apoptosome</title><author>D'Brot, Alejandro ; 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| subjects | Animals Apoptosomes - metabolism Aryl Hydrocarbon Receptor Nuclear Translocator - genetics Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism Caspases - metabolism Drosophila Drosophila melanogaster - cytology Drosophila melanogaster - enzymology Drosophila Proteins - genetics Drosophila Proteins - metabolism Fertility - genetics Genetic Variation Male Mutation Research Communication Spermatogenesis - genetics Spermatozoa - enzymology Spermatozoa - metabolism |
| title | Tango7 directs cellular remodeling by the Drosophila apoptosome |
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