Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia
Objective: Folate is involved in the one-carbon metabolism that plays an essential role in the synthesis, repair, and methylation of DNA. We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether per...
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| Veröffentlicht in: | Cancer causes & control 2011-09, Vol.22 (9), p.1243-1258 |
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| creator | Metayer, Catherine Scélo, Ghislaine Chokkalingam, Anand P. Barcellos, Lisa F. Aldrich, Melinda C. Chang, Jeffrey S. Guha, Neela Urayama, Kevin Y. Hansen, Helen M. Block, Gladys Kiley, Vincent Wiencke, John K. Wiemels, Joseph L. Buffler, Patricia A. |
| description | Objective: Folate is involved in the one-carbon metabolism that plays an essential role in the synthesis, repair, and methylation of DNA. We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether periconception maternal folate and alcohol intake modify the risk. Methods: Seventy-six single nucleotide polymorphisms (SNPs), including 66 haplotype-tagging SNPs in 10 genes (CBS, DHFR, FOLH1, MTHFD1, MTHFR, MTR, MTRR, SHMT1, SLC19A1, and TYMS), were genotyped in 377 ALL cases and 448 controls. Log-additive associations between genotypes and ALL risk were adjusted for age, sex, Hispanic ethnicity (when appropriate), and maternal race. Results: Single and haplotype SNPs analyses showed statistically significant associations between SNPs located in (or adjacent to) CBS, MTRR, TYMS/ENOFS, and childhood ALL. Many regions of CBS were associated with childhood ALL in Hispanics and non-Hispanics (p < 0.01). Levels of maternal folate intake modified associations with SNPs in CBS, MTRR, and TYMS. Conclusion: Our data suggest the importance of genetic variability in the folate pathway and childhood ALL risk. |
| doi_str_mv | 10.1007/s10552-011-9795-7 |
| format | Article |
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We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether periconception maternal folate and alcohol intake modify the risk. Methods: Seventy-six single nucleotide polymorphisms (SNPs), including 66 haplotype-tagging SNPs in 10 genes (CBS, DHFR, FOLH1, MTHFD1, MTHFR, MTR, MTRR, SHMT1, SLC19A1, and TYMS), were genotyped in 377 ALL cases and 448 controls. Log-additive associations between genotypes and ALL risk were adjusted for age, sex, Hispanic ethnicity (when appropriate), and maternal race. Results: Single and haplotype SNPs analyses showed statistically significant associations between SNPs located in (or adjacent to) CBS, MTRR, TYMS/ENOFS, and childhood ALL. Many regions of CBS were associated with childhood ALL in Hispanics and non-Hispanics (p < 0.01). Levels of maternal folate intake modified associations with SNPs in CBS, MTRR, and TYMS. Conclusion: Our data suggest the importance of genetic variability in the folate pathway and childhood ALL risk.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1007/s10552-011-9795-7</identifier><identifier>PMID: 21748308</identifier><identifier>CODEN: CCCNEN</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Acute lymphatic leukemia ; Alcohol ; Alcohol drinking ; Alcohol Drinking - adverse effects ; Alcohol Drinking - genetics ; Alcohol Drinking - metabolism ; Alcoholic beverages ; Bioavailability ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cancer Research ; Carbon ; Case-Control Studies ; Child ; Child, Preschool ; Childhood ; Children ; Children & youth ; Data processing ; Dihydrofolate reductase ; DNA ; DNA methylation ; Epidemiology ; Ethnic groups ; Ethnicity ; Female ; Folic acid ; Folic Acid - administration & dosage ; Folic Acid - genetics ; Folic Acid - metabolism ; Genes ; Genetic diversity ; Genetic Predisposition to Disease ; Genetic Variation ; Genotype ; Haplotypes ; Hematology ; Hispanic people ; Hispanics ; Human subjects ; Humans ; Infant ; Infant, Newborn ; Leukemia ; Lymphocytic leukemia ; Male ; Medical research ; Metabolism ; Methylenetetrahydrofolate reductase ; Oncology ; Original Paper ; Polymorphism, Single Nucleotide ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism ; Pregnancy ; Public Health ; Risk Factors ; Single-nucleotide polymorphism ; Statistical analysis ; Vitamin B</subject><ispartof>Cancer causes & control, 2011-09, Vol.22 (9), p.1243-1258</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-eafee171691e329cbe810d0b9bbab5c6d49f204bacb9e7c96976f0ab8837feb43</citedby><cites>FETCH-LOGICAL-c522t-eafee171691e329cbe810d0b9bbab5c6d49f204bacb9e7c96976f0ab8837feb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41485206$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41485206$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,27924,27925,41488,42557,51319,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21748308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Metayer, Catherine</creatorcontrib><creatorcontrib>Scélo, Ghislaine</creatorcontrib><creatorcontrib>Chokkalingam, Anand P.</creatorcontrib><creatorcontrib>Barcellos, Lisa F.</creatorcontrib><creatorcontrib>Aldrich, Melinda C.</creatorcontrib><creatorcontrib>Chang, Jeffrey S.</creatorcontrib><creatorcontrib>Guha, Neela</creatorcontrib><creatorcontrib>Urayama, Kevin Y.</creatorcontrib><creatorcontrib>Hansen, Helen M.</creatorcontrib><creatorcontrib>Block, Gladys</creatorcontrib><creatorcontrib>Kiley, Vincent</creatorcontrib><creatorcontrib>Wiencke, John K.</creatorcontrib><creatorcontrib>Wiemels, Joseph L.</creatorcontrib><creatorcontrib>Buffler, Patricia A.</creatorcontrib><title>Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia</title><title>Cancer causes & control</title><addtitle>Cancer Causes Control</addtitle><addtitle>Cancer Causes Control</addtitle><description>Objective: Folate is involved in the one-carbon metabolism that plays an essential role in the synthesis, repair, and methylation of DNA. We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether periconception maternal folate and alcohol intake modify the risk. Methods: Seventy-six single nucleotide polymorphisms (SNPs), including 66 haplotype-tagging SNPs in 10 genes (CBS, DHFR, FOLH1, MTHFD1, MTHFR, MTR, MTRR, SHMT1, SLC19A1, and TYMS), were genotyped in 377 ALL cases and 448 controls. Log-additive associations between genotypes and ALL risk were adjusted for age, sex, Hispanic ethnicity (when appropriate), and maternal race. Results: Single and haplotype SNPs analyses showed statistically significant associations between SNPs located in (or adjacent to) CBS, MTRR, TYMS/ENOFS, and childhood ALL. Many regions of CBS were associated with childhood ALL in Hispanics and non-Hispanics (p < 0.01). Levels of maternal folate intake modified associations with SNPs in CBS, MTRR, and TYMS. Conclusion: Our data suggest the importance of genetic variability in the folate pathway and childhood ALL risk.</description><subject>Acute lymphatic leukemia</subject><subject>Alcohol</subject><subject>Alcohol drinking</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol Drinking - genetics</subject><subject>Alcohol Drinking - metabolism</subject><subject>Alcoholic beverages</subject><subject>Bioavailability</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Carbon</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Children & youth</subject><subject>Data processing</subject><subject>Dihydrofolate reductase</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>Epidemiology</subject><subject>Ethnic groups</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Folic acid</subject><subject>Folic Acid - administration & dosage</subject><subject>Folic Acid - genetics</subject><subject>Folic Acid - metabolism</subject><subject>Genes</subject><subject>Genetic diversity</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Hematology</subject><subject>Hispanic people</subject><subject>Hispanics</subject><subject>Human subjects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Leukemia</subject><subject>Lymphocytic leukemia</subject><subject>Male</subject><subject>Medical research</subject><subject>Metabolism</subject><subject>Methylenetetrahydrofolate reductase</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism</subject><subject>Pregnancy</subject><subject>Public Health</subject><subject>Risk Factors</subject><subject>Single-nucleotide polymorphism</subject><subject>Statistical analysis</subject><subject>Vitamin B</subject><issn>0957-5243</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkT2P1DAQhi0E4paDH0ABsmioAmPHjuMGCZ3gQDqJBgoqy3YmF-9l48VODu2_x6scy0eBqFzMM49n5iXkKYNXDEC9zgyk5BUwVmmlZaXukQ2Tqq4U5_I-2YCWqpJc1GfkUc5bAJANh4fkjDMl2hraDfl6iRPOwdNbm4Kd5kzDROcBaR9HOyPd23n4bg_UTh1NId_Q2FM_hLEbYuyo9UthxsNuP0Q32nwUjbjc4C7Yx-RBb8eMT-7ec_Ll_bvPFx-qq0-XHy_eXlVecj5XaHtEplijGdZce4ctgw6cds466ZtO6J6DcNY7jcrrRqumB-vatlY9OlGfkzerd7-4HXYepznZ0exT2Nl0MNEG82dlCoO5jremVkJA0xTByztBit8WzLPZhexxHO2EccmmbSVIxeB_SFBMlGkL-eIvchuXNJU7HCGoWa10gdgK-RRzTtifhmZgjgGbNWBTAjbHgI0qPc9_3_bU8TPRAvAVyKU0XWP69fO_rM_Wpm2eYzpJBROt5GXxH9I8vE0</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Metayer, Catherine</creator><creator>Scélo, Ghislaine</creator><creator>Chokkalingam, Anand P.</creator><creator>Barcellos, Lisa F.</creator><creator>Aldrich, Melinda C.</creator><creator>Chang, Jeffrey S.</creator><creator>Guha, Neela</creator><creator>Urayama, Kevin Y.</creator><creator>Hansen, Helen M.</creator><creator>Block, Gladys</creator><creator>Kiley, Vincent</creator><creator>Wiencke, John K.</creator><creator>Wiemels, Joseph L.</creator><creator>Buffler, Patricia A.</creator><general>Springer</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20110901</creationdate><title>Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia</title><author>Metayer, Catherine ; Scélo, Ghislaine ; Chokkalingam, Anand P. ; Barcellos, Lisa F. ; Aldrich, Melinda C. ; Chang, Jeffrey S. ; Guha, Neela ; Urayama, Kevin Y. ; Hansen, Helen M. ; Block, Gladys ; Kiley, Vincent ; Wiencke, John K. ; Wiemels, Joseph L. ; Buffler, Patricia A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-eafee171691e329cbe810d0b9bbab5c6d49f204bacb9e7c96976f0ab8837feb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute lymphatic leukemia</topic><topic>Alcohol</topic><topic>Alcohol drinking</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcohol Drinking - genetics</topic><topic>Alcohol Drinking - metabolism</topic><topic>Alcoholic beverages</topic><topic>Bioavailability</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Carbon</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Childhood</topic><topic>Children</topic><topic>Children & youth</topic><topic>Data processing</topic><topic>Dihydrofolate reductase</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>Epidemiology</topic><topic>Ethnic groups</topic><topic>Ethnicity</topic><topic>Female</topic><topic>Folic acid</topic><topic>Folic Acid - administration & dosage</topic><topic>Folic Acid - genetics</topic><topic>Folic Acid - metabolism</topic><topic>Genes</topic><topic>Genetic diversity</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic Variation</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Hematology</topic><topic>Hispanic people</topic><topic>Hispanics</topic><topic>Human subjects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Leukemia</topic><topic>Lymphocytic leukemia</topic><topic>Male</topic><topic>Medical research</topic><topic>Metabolism</topic><topic>Methylenetetrahydrofolate reductase</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism</topic><topic>Pregnancy</topic><topic>Public Health</topic><topic>Risk Factors</topic><topic>Single-nucleotide polymorphism</topic><topic>Statistical analysis</topic><topic>Vitamin B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Metayer, Catherine</creatorcontrib><creatorcontrib>Scélo, Ghislaine</creatorcontrib><creatorcontrib>Chokkalingam, Anand P.</creatorcontrib><creatorcontrib>Barcellos, Lisa F.</creatorcontrib><creatorcontrib>Aldrich, Melinda C.</creatorcontrib><creatorcontrib>Chang, Jeffrey S.</creatorcontrib><creatorcontrib>Guha, Neela</creatorcontrib><creatorcontrib>Urayama, Kevin Y.</creatorcontrib><creatorcontrib>Hansen, Helen M.</creatorcontrib><creatorcontrib>Block, Gladys</creatorcontrib><creatorcontrib>Kiley, Vincent</creatorcontrib><creatorcontrib>Wiencke, John K.</creatorcontrib><creatorcontrib>Wiemels, Joseph L.</creatorcontrib><creatorcontrib>Buffler, Patricia A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer causes & control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Metayer, Catherine</au><au>Scélo, Ghislaine</au><au>Chokkalingam, Anand P.</au><au>Barcellos, Lisa F.</au><au>Aldrich, Melinda C.</au><au>Chang, Jeffrey S.</au><au>Guha, Neela</au><au>Urayama, Kevin Y.</au><au>Hansen, Helen M.</au><au>Block, Gladys</au><au>Kiley, Vincent</au><au>Wiencke, John K.</au><au>Wiemels, Joseph L.</au><au>Buffler, Patricia A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia</atitle><jtitle>Cancer causes & control</jtitle><stitle>Cancer Causes Control</stitle><addtitle>Cancer Causes Control</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>22</volume><issue>9</issue><spage>1243</spage><epage>1258</epage><pages>1243-1258</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><coden>CCCNEN</coden><abstract>Objective: Folate is involved in the one-carbon metabolism that plays an essential role in the synthesis, repair, and methylation of DNA. We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether periconception maternal folate and alcohol intake modify the risk. Methods: Seventy-six single nucleotide polymorphisms (SNPs), including 66 haplotype-tagging SNPs in 10 genes (CBS, DHFR, FOLH1, MTHFD1, MTHFR, MTR, MTRR, SHMT1, SLC19A1, and TYMS), were genotyped in 377 ALL cases and 448 controls. Log-additive associations between genotypes and ALL risk were adjusted for age, sex, Hispanic ethnicity (when appropriate), and maternal race. Results: Single and haplotype SNPs analyses showed statistically significant associations between SNPs located in (or adjacent to) CBS, MTRR, TYMS/ENOFS, and childhood ALL. Many regions of CBS were associated with childhood ALL in Hispanics and non-Hispanics (p < 0.01). Levels of maternal folate intake modified associations with SNPs in CBS, MTRR, and TYMS. Conclusion: Our data suggest the importance of genetic variability in the folate pathway and childhood ALL risk.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>21748308</pmid><doi>10.1007/s10552-011-9795-7</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute lymphatic leukemia Alcohol Alcohol drinking Alcohol Drinking - adverse effects Alcohol Drinking - genetics Alcohol Drinking - metabolism Alcoholic beverages Bioavailability Biomedical and Life Sciences Biomedicine Cancer Cancer Research Carbon Case-Control Studies Child Child, Preschool Childhood Children Children & youth Data processing Dihydrofolate reductase DNA DNA methylation Epidemiology Ethnic groups Ethnicity Female Folic acid Folic Acid - administration & dosage Folic Acid - genetics Folic Acid - metabolism Genes Genetic diversity Genetic Predisposition to Disease Genetic Variation Genotype Haplotypes Hematology Hispanic people Hispanics Human subjects Humans Infant Infant, Newborn Leukemia Lymphocytic leukemia Male Medical research Metabolism Methylenetetrahydrofolate reductase Oncology Original Paper Polymorphism, Single Nucleotide Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Pregnancy Public Health Risk Factors Single-nucleotide polymorphism Statistical analysis Vitamin B |
| title | Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia |
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