Noncanonical Matrix Metalloprotease-1-Protease-activated Receptor-1 Signaling Triggers Vascular Smooth Muscle Cell Dedifferentiation and Arterial Stenosis

Vascular injury that results in proliferation and dedifferentiation of vascular smooth muscle cells (SMCs) is an important contributor to restenosis following percutaneous coronary interventions or plaque rupture. Protease-activated receptor-1 (PAR1) has been shown to play a role in vascular repair...

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Veröffentlicht in:The Journal of biological chemistry 2013-08, Vol.288 (32), p.23105-23115
Hauptverfasser: Austin, Karyn M., Nguyen, Nga, Javid, Golrokh, Covic, Lidija, Kuliopulos, Athan
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Sprache:eng
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