Calcineurin signaling mediates activity-dependent relocation of the axon initial segment

The axon initial segment (AIS) is a specialized neuronal subcompartment located at the beginning of the axon that is crucially involved in both the generation of action potentials and the regulation of neuronal polarity. We recently showed that prolonged neuronal depolarization produces a distal shi...

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Veröffentlicht in:	The Journal of neuroscience 2013-04, Vol.33 (16), p.6950-6963
Hauptverfasser:	Evans, Mark D, Sammons, Rosanna P, Lebron, Sabrina, Dumitrescu, Adna S, Watkins, Thomas B K, Uebele, Victor N, Renger, John J, Grubb, Matthew S
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Animals Axons - metabolism Benzamides - pharmacology Calcineurin - genetics Calcineurin - metabolism Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Cells, Cultured Channelrhodopsins Dendritic Spines - metabolism Embryo, Mammalian Excitatory Amino Acid Antagonists - pharmacology Hippocampus - cytology Homeodomain Proteins - metabolism Luminescent Proteins - genetics Luminescent Proteins - metabolism Neurons - cytology NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism Photic Stimulation Piperidines - pharmacology Rats Rats, Wistar Signal Transduction - genetics Signal Transduction - physiology Transfection Tumor Suppressor Proteins - metabolism
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