Insulin-like growth factor-I stimulates differentiation of ATII cells to ATI-like cells through activation of Wnt5a

Alveolar type II (ATII) epithelial cells play a crucial role in the repair and remodeling of the lung following injury. ATII cells have the capability to proliferate and differentiate into alveolar type I (ATI) cells in vivo and into an ATI-like phenotype in vitro. While previous reports indicate th...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2013-08, Vol.305 (3), p.L222-L228
Hauptverfasser:	Ghosh, Manik C, Gorantla, Vijay, Makena, Patrudu S, Luellen, Charlean, Sinclair, Scott E, Schwingshackl, Andreas, Waters, Christopher M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoquinolines - pharmacology Animals beta Catenin - metabolism Cell Differentiation Cell Proliferation Cell Transdifferentiation Cells Cells, Cultured Culture media Enzyme Activation Genotype & phenotype Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - pharmacology Insulin-Like Growth Factor I - physiology Insulin-like growth factors Kinases Lung diseases Mice Phenylurea Compounds - pharmacology Polymerase chain reaction Protein Kinase C - metabolism Pulmonary Alveoli - cytology Pulmonary Alveoli - metabolism Rats Recombinant Proteins - pharmacology Ribonucleic acid RNA RNA Interference RNA, Messenger - metabolism RNA, Small Interfering Wnt Proteins - genetics Wnt Proteins - metabolism Wnt Proteins - pharmacology Wnt-5a Protein Wound Healing
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