Development of a Fluorescence Internal Quenching Correction Factor to Correct BoNT/A Endopeptidase Kinetics using SNAPtide

Botulinum neurotoxins (BoNTs), which are highly toxic proteins responsible for botulism, are produced by different strains of Clostridium botulinum . These various strains of bacteria produce seven distinct serotypes, labeled A-G. Once inside cells, the zinc-dependent proteolytic light chain (LC) de...

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Veröffentlicht in:	Analytical chemistry (Washington) 2012-12, Vol.84 (24), p.10549-10553
Hauptverfasser:	Feltrup, Thomas M., Singh, Bal Ram
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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