Epigenetic silencing of Bim transcription by Spi-1/PU.1 promotes apoptosis resistance in leukaemia

Deregulation of transcriptional networks contributes to haematopoietic malignancies. The transcription factor Spi-1/PU.1 is a master regulator of haematopoiesis and its alteration leads to leukaemia. Spi-1 overexpression inhibits differentiation and promotes resistance to apoptosis in erythroleukaem...

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Veröffentlicht in:	Cell death and differentiation 2013-09, Vol.20 (9), p.1268-1278
Hauptverfasser:	Ridinger-Saison, M, Evanno, E, Gallais, I, Rimmelé, P, Selimoglu-Buet, D, Sapharikas, E, Moreau-Gachelin, F, Guillouf, C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/176/2016 631/67/1990/283 631/80/82/23 Animals Apoptosis Apoptosis - genetics Apoptosis Regulatory Proteins - genetics Bcl-2-Like Protein 11 Binding Sites - genetics Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell death Cell Differentiation - genetics Cell growth Cell Line DNA Methylation DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - metabolism Enhancer of Zeste Homolog 2 Protein Epigenetics Gene Expression Regulation, Leukemic Histone-Lysine N-Methyltransferase - metabolism Histones - metabolism Leukemia Leukemia, Myeloid, Acute - genetics Life Sciences Membrane Proteins - genetics Mice Mice, Transgenic Mitochondria - genetics Mitochondria - metabolism Multiprotein Complexes - genetics Mutation Myeloid Cell Leukemia Sequence 1 Protein - metabolism Original Paper Polycomb Repressive Complex 2 - metabolism Promoter Regions, Genetic Protein Binding Proteins Proto-Oncogene Proteins - genetics RNA Interference RNA, Small Interfering Stem Cells Transcription factors Transcription, Genetic - genetics Transgenic animals
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