Candidate gene linkage approach to identify DNA variants that predispose to preterm birth

Background: The aim of this study was to identify genetic variants contributing to preterm birth (PTB) using a linkage candidate gene approach. Methods: We studied 99 single-nucleotide polymorphisms (SNPs) for 33 genes in 257 families with PTBs segregating. Nonparametric and parametric analyses were...

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Veröffentlicht in:	Pediatric research 2013-02, Vol.73 (2), p.135-141
Hauptverfasser:	Bream, Elise N.A., Leppellere, Cara R., Cooper, Margaret E., Dagle, John M., Merrill, David C., Christensen, Kaare, Simhan, Hyagriv N., Fong, Chin-To, Hallman, Mikko, Muglia, Louis J., Marazita, Mary L., Murray, Jeffrey C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/207 631/208/727/2000 692/700/1720 basic-science-investigation Cytochrome P-450 CYP2E1 - genetics Denmark Genetic Association Studies Genetic Linkage Genetic Predisposition to Disease Gestational Age Humans Infant, Newborn Infant, Premature Insulin-Like Growth Factor Binding Protein 3 - genetics Medicine Medicine & Public Health Oxidoreductases Acting on CH-CH Group Donors - genetics Pediatric Surgery Pediatrics Phenotype Phosphoric Diester Hydrolases - genetics Polymorphism, Single Nucleotide Premature Birth - genetics Pyrophosphatases - genetics Receptors, Corticotropin-Releasing Hormone - genetics Risk Assessment Risk Factors TNF Receptor-Associated Factor 2 - genetics United States
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