Free Fatty Acids Induce Lhb mRNA but Suppress Fshb mRNA in Pituitary LβT2 Gonadotropes and Diet-Induced Obesity Reduces FSH Levels in Male Mice and Disrupts the Proestrous LH/FSH Surge in Female Mice

Female obesity is associated with insulin resistance, hyperandrogenemia, and reproductive dysfunction. We hypothesized that elevated free fatty acids (FFAs) might directly modulate pituitary gonadotropin production. FFAs caused a time- and dose-dependent increase in phosphorylation of the MAPKs p38M...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2013-06, Vol.154 (6), p.2188-2199
Hauptverfasser:	Sharma, Shweta, Morinaga, Hidetaka, Hwang, Vicky, Fan, WuQiang, Fernandez, Marina O, Varki, Nissi, Olefsky, Jerrold M, Webster, Nicholas J. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid resistance Activin Animals Biological and medical sciences c-Jun protein Diet Diet, High-Fat - adverse effects Dose-Response Relationship, Drug Estrus cycle Extracellular signal-regulated kinase Fatty acids Fatty Acids, Nonesterified - pharmacology Female Females Follicle Stimulating Hormone, beta Subunit - blood Follicle Stimulating Hormone, beta Subunit - genetics Follicle Stimulating Hormone, beta Subunit - metabolism Follicle-stimulating hormone Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - drug effects Gonadotrophs - cytology Gonadotrophs - drug effects Gonadotrophs - metabolism Gonadotropin-releasing hormone Gonadotropins High fat diet Immunoblotting Insulin resistance JNK protein Kinases Lipids Lipopolysaccharides Luteinizing hormone Luteinizing Hormone, beta Subunit - blood Luteinizing Hormone, beta Subunit - genetics Luteinizing Hormone, beta Subunit - metabolism Male Males MAP kinase Medical sciences Metabolic diseases Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinases - metabolism Obesity Obesity - etiology Obesity - genetics Obesity - metabolism Ovaries Ovary - drug effects Ovary - metabolism Phosphorylation Pituitary Pituitary (anterior) Pituitary Gland - cytology Proestrus - drug effects Proestrus - genetics Proestrus - metabolism Reproduction-Development Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Messenger - genetics RNA, Messenger - metabolism Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Transcription factors Tubules Vertebrates: endocrinology
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