LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo

Reactivation of fetal hemoglobin (HbF) holds therapeutic potential for sickle cell disease and β-thalassemias. In human erythroid cells and hematopoietic organs, LIN28B and its targeted let-7 microRNA family, demonstrate regulated expression during the fetal-to-adult developmental transition. To exp...

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Veröffentlicht in:	Blood 2013-08, Vol.122 (6), p.1034-1041
Hauptverfasser:	Lee, Y. Terry, de Vasconcellos, Jaira F., Yuan, Joan, Byrnes, Colleen, Noh, Seung-Jae, Meier, Emily R., Kim, Ki Soon, Rabel, Antoinette, Kaushal, Megha, Muljo, Stefan A., Miller, Jeffery L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD34 - metabolism Carbonic Anhydrase I - metabolism Cell Culture Techniques DNA-Binding Proteins - metabolism Erythroblasts - cytology Erythrocytes - cytology Fetal Blood - cytology Fetal Hemoglobin - metabolism Gene Expression Regulation Hemoglobin A - metabolism Humans MicroRNAs - metabolism N-Acetylglucosaminyltransferases - metabolism Phenotype Red Cells, Iron, and Erythropoiesis RNA-Binding Proteins
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