Treatment of Chronic Rhinosinusitis with Pressure-Pulsed Corticosteroid Inhalation
Chronic rhinosinusitis may cause olfactory dysfunction and affects quality of life in patients. In a prospective study we investigated the effect of topical application of corticosteroids through pressure-pulsed inhalation as treatment option of chronic rhinosinusitis with olfactory disorder. Patien...
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Veröffentlicht in: | Indian journal of otolaryngology, and head, and neck surgery and head, and neck surgery, 2013-08, Vol.65 (Suppl 2), p.402-405 |
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description | Chronic rhinosinusitis may cause olfactory dysfunction and affects quality of life in patients. In a prospective study we investigated the effect of topical application of corticosteroids through pressure-pulsed inhalation as treatment option of chronic rhinosinusitis with olfactory disorder. Patients with sinonasal olfactory disorder according to the European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) were allocated to the new nasal inhalation therapy or a systemic corticosteroid therapy, each receiving a corticosteroid course of 12 days. 18 patients received topical corticosteroid pressure-pulsed inhalation (AMSA, Schumacher, Dausenau) and 15 systemic corticosteroid. Olfactory function was measured before and after treatment using the Threshold Discrimination Identification score (TDI score) and visual analogue scales. Lund Mackay score (LMS) was measured before starting treatment. Olfactory function (OF) increased from 17.5 ± 6.4 to 21 ± 7.9 TDI points (
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p
< 0.0005) after 2 months. OF decreased again to 19.5 ± 6.0 after 6 months (
p
= 0.007). OF increased from 17.0 ± 8.9 to 22.0 ± 9.5 points (
p
= 0.002) with systemic treatment after 2 months. In the follow-up period of 6 months, the mean TDI score dropped to 20.0 ± 9.2 points (
p
= 0.01). There was no correlation between LMS and TDI. Treatment of chronic rhinosinusitis with pressure-pulsed inhalation was demonstrated to be effective. Multicenter investigations with large participant numbers are needed.</description><identifier>ISSN: 2231-3796</identifier><identifier>EISSN: 0973-7707</identifier><identifier>DOI: 10.1007/s12070-013-0625-y</identifier><identifier>PMID: 24427686</identifier><language>eng</language><publisher>India: Springer India</publisher><subject>Chronic illnesses ; Drug delivery systems ; Head and Neck Surgery ; Medicine ; Medicine & Public Health ; Nose ; Original ; Original Article ; Otolaryngology ; Otorhinolaryngology ; Sensory perception ; Sinuses ; Steroids</subject><ispartof>Indian journal of otolaryngology, and head, and neck surgery, 2013-08, Vol.65 (Suppl 2), p.402-405</ispartof><rights>Association of Otolaryngologists of India 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-797098850770fa9071fb6c20b5d12ffdc01e07db3cafdd1872788ed3f2c824dc3</citedby><cites>FETCH-LOGICAL-c470t-797098850770fa9071fb6c20b5d12ffdc01e07db3cafdd1872788ed3f2c824dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738806/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738806/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24427686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goektas, Oender</creatorcontrib><creatorcontrib>Lau, Larissa</creatorcontrib><creatorcontrib>Olze, Heidi</creatorcontrib><title>Treatment of Chronic Rhinosinusitis with Pressure-Pulsed Corticosteroid Inhalation</title><title>Indian journal of otolaryngology, and head, and neck surgery</title><addtitle>Indian J Otolaryngol Head Neck Surg</addtitle><addtitle>Indian J Otolaryngol Head Neck Surg</addtitle><description>Chronic rhinosinusitis may cause olfactory dysfunction and affects quality of life in patients. In a prospective study we investigated the effect of topical application of corticosteroids through pressure-pulsed inhalation as treatment option of chronic rhinosinusitis with olfactory disorder. Patients with sinonasal olfactory disorder according to the European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) were allocated to the new nasal inhalation therapy or a systemic corticosteroid therapy, each receiving a corticosteroid course of 12 days. 18 patients received topical corticosteroid pressure-pulsed inhalation (AMSA, Schumacher, Dausenau) and 15 systemic corticosteroid. Olfactory function was measured before and after treatment using the Threshold Discrimination Identification score (TDI score) and visual analogue scales. Lund Mackay score (LMS) was measured before starting treatment. Olfactory function (OF) increased from 17.5 ± 6.4 to 21 ± 7.9 TDI points (
p
< 0.0005) after 2 months. OF decreased again to 19.5 ± 6.0 after 6 months (
p
= 0.007). OF increased from 17.0 ± 8.9 to 22.0 ± 9.5 points (
p
= 0.002) with systemic treatment after 2 months. In the follow-up period of 6 months, the mean TDI score dropped to 20.0 ± 9.2 points (
p
= 0.01). There was no correlation between LMS and TDI. Treatment of chronic rhinosinusitis with pressure-pulsed inhalation was demonstrated to be effective. Multicenter investigations with large participant numbers are needed.</description><subject>Chronic illnesses</subject><subject>Drug delivery systems</subject><subject>Head and Neck Surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nose</subject><subject>Original</subject><subject>Original Article</subject><subject>Otolaryngology</subject><subject>Otorhinolaryngology</subject><subject>Sensory perception</subject><subject>Sinuses</subject><subject>Steroids</subject><issn>2231-3796</issn><issn>0973-7707</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kU9rFTEUxYMo9tn6AdzIgBs30ZtkZm5mI8jD1kKhpbTrkJc_nZR5SU1mKu_bm_JqqUJXd3F_99xzOIR8YPCFAeDXwjggUGCCQs87untFVjCgoIiAr8mKc8GowKE_IO9KuQUQHUN4Sw5423LsZb8il1fZ6Xnr4twk36zHnGIwzeUYYiohLiXMoTS_wzw2F9mVsmRHL5apONusU56DSWV2OQXbnMZRT3oOKR6RN15X5P3jPCTXxz-u1j_p2fnJ6fr7GTUtwkxxQBik7KCa9XoAZH7TGw6bzjLuvTXAHKDdCKO9tUwiRymdFZ4byVtrxCH5tte9WzZbZ03NkPWk7nLY6rxTSQf17yaGUd2keyVQSAl9Ffj8KJDTr8WVWW1DMW6adHRpKYq11VU_tKyr6Kf_0Nu05FjjKdYjCBDY8UqxPWVyKiU7_2SGgXpoTO0bU7Ux9dCY2tWbj89TPF38ragCfA-Uuoo3Lj97_aLqH2Jko3c</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Goektas, Oender</creator><creator>Lau, Larissa</creator><creator>Olze, Heidi</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>04Q</scope><scope>04T</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130801</creationdate><title>Treatment of Chronic Rhinosinusitis with Pressure-Pulsed Corticosteroid Inhalation</title><author>Goektas, Oender ; Lau, Larissa ; Olze, Heidi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-797098850770fa9071fb6c20b5d12ffdc01e07db3cafdd1872788ed3f2c824dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Chronic illnesses</topic><topic>Drug delivery systems</topic><topic>Head and Neck Surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nose</topic><topic>Original</topic><topic>Original Article</topic><topic>Otolaryngology</topic><topic>Otorhinolaryngology</topic><topic>Sensory perception</topic><topic>Sinuses</topic><topic>Steroids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goektas, Oender</creatorcontrib><creatorcontrib>Lau, Larissa</creatorcontrib><creatorcontrib>Olze, Heidi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>India Database</collection><collection>India Database: Health & Medicine</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of otolaryngology, and head, and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goektas, Oender</au><au>Lau, Larissa</au><au>Olze, Heidi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of Chronic Rhinosinusitis with Pressure-Pulsed Corticosteroid Inhalation</atitle><jtitle>Indian journal of otolaryngology, and head, and neck surgery</jtitle><stitle>Indian J Otolaryngol Head Neck Surg</stitle><addtitle>Indian J Otolaryngol Head Neck Surg</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>65</volume><issue>Suppl 2</issue><spage>402</spage><epage>405</epage><pages>402-405</pages><issn>2231-3796</issn><eissn>0973-7707</eissn><abstract>Chronic rhinosinusitis may cause olfactory dysfunction and affects quality of life in patients. In a prospective study we investigated the effect of topical application of corticosteroids through pressure-pulsed inhalation as treatment option of chronic rhinosinusitis with olfactory disorder. Patients with sinonasal olfactory disorder according to the European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) were allocated to the new nasal inhalation therapy or a systemic corticosteroid therapy, each receiving a corticosteroid course of 12 days. 18 patients received topical corticosteroid pressure-pulsed inhalation (AMSA, Schumacher, Dausenau) and 15 systemic corticosteroid. Olfactory function was measured before and after treatment using the Threshold Discrimination Identification score (TDI score) and visual analogue scales. Lund Mackay score (LMS) was measured before starting treatment. Olfactory function (OF) increased from 17.5 ± 6.4 to 21 ± 7.9 TDI points (
p
< 0.0005) after 2 months. OF decreased again to 19.5 ± 6.0 after 6 months (
p
= 0.007). OF increased from 17.0 ± 8.9 to 22.0 ± 9.5 points (
p
= 0.002) with systemic treatment after 2 months. In the follow-up period of 6 months, the mean TDI score dropped to 20.0 ± 9.2 points (
p
= 0.01). There was no correlation between LMS and TDI. Treatment of chronic rhinosinusitis with pressure-pulsed inhalation was demonstrated to be effective. Multicenter investigations with large participant numbers are needed.</abstract><cop>India</cop><pub>Springer India</pub><pmid>24427686</pmid><doi>10.1007/s12070-013-0625-y</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Chronic illnesses Drug delivery systems Head and Neck Surgery Medicine Medicine & Public Health Nose Original Original Article Otolaryngology Otorhinolaryngology Sensory perception Sinuses Steroids |
title | Treatment of Chronic Rhinosinusitis with Pressure-Pulsed Corticosteroid Inhalation |
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