Structural dynamics of possible late-stage intermediates in folding of quadruplex DNA studied by molecular simulations

Explicit solvent molecular dynamics simulations have been used to complement preceding experimental and computational studies of folding of guanine quadruplexes (G-DNA). We initiate early stages of unfolding of several G-DNAs by simulating them under no-salt conditions and then try to fold them back...

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Veröffentlicht in:	Nucleic acids research 2013-08, Vol.41 (14), p.7128-7143
Hauptverfasser:	Stadlbauer, Petr, Krepl, Miroslav, Cheatham, 3rd, Thomas E, Koca, Jaroslav, Sponer, Jirí
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemistry DNA, Single-Stranded - chemistry G-Quadruplexes Humans Molecular Dynamics Simulation Structural Biology Telomere - chemistry
Online-Zugang:	Volltext
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