Human adipose microRNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-α

Aims/hypothesis MicroRNAs (miRNAs) are short endogenous RNAs that regulate multiple biological processes including adipogenesis and fat metabolism. We sought to identify miRNAs that correlate with BMI and to elucidate their upstream regulation and downstream targets. Methods Microarray-based express...

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Veröffentlicht in:	Diabetologia 2013-09, Vol.56 (9), p.1971-1979
Hauptverfasser:	Meerson, A., Traurig, M., Ossowski, V., Fleming, J. M., Mullins, M., Baier, L. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Biological and medical sciences Blotting, Western Body Mass Index Cells, Cultured Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Human Physiology Humans Internal Medicine Leptin - genetics Leptin - metabolism Lipid Metabolism - genetics Lipid Metabolism - physiology Medical sciences Medicine Medicine & Public Health Metabolic Diseases MicroRNAs - genetics MicroRNAs - metabolism Obesity Obesity - genetics Obesity - metabolism Oligonucleotide Array Sequence Analysis Proteomics Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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