Pregnancy-related characteristics and breast cancer risk
Breast tissues undergo extensive physiologic changes during pregnancy, which may affect breast carcinogenesis. Gestational hypertension, preeclampsia/eclampsia, gestational diabetes, pregnancy weight gain, and nausea and vomiting (N&V) during pregnancy may be indicative of altered hormonal and m...
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| Veröffentlicht in: | Cancer causes & control 2013-09, Vol.24 (9), p.1675-1685 |
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| creator | Brasky, Theodore M. Li, Yanli Jaworowicz, David J. Potischman, Nancy Ambrosone, Christine B. Hutson, Alan D. Nie, Jing Shields, Peter G. Trevisan, Maurizio Rudra, Carole B. Edge, Stephen B. Freudenheim, Jo L. |
| description | Breast tissues undergo extensive physiologic changes during pregnancy, which may affect breast carcinogenesis. Gestational hypertension, preeclampsia/eclampsia, gestational diabetes, pregnancy weight gain, and nausea and vomiting (N&V) during pregnancy may be indicative of altered hormonal and metabolic profiles and could impact breast cancer risk. Here, we examined associations between these characteristics of a woman's pregnancy and her subsequent breast cancer risk. Participants were parous women that were recruited to a population-based case–control study (Western New York Exposures and Breast Cancer Study). Cases (n = 960), aged 35–79 years, had incident, primary, histologically confirmed breast cancer. Controls (n = 1,852) were randomly selected from motor vehicle records ( |
| doi_str_mv | 10.1007/s10552-013-0242-9 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3737361</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>24717794</jstor_id><sourcerecordid>24717794</sourcerecordid><originalsourceid>FETCH-LOGICAL-c525t-ad275729f23069bf2e3fc1f68f3753d93a03293f1e6185f8210e5ef922198bbb3</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhi0EokvhB3AAReLCxe14Jo7jC1JV8SVVogc4W44z3mbJJsXOIvXfkyilFA4VJx_eZx57_ArxUsGJAjCnWYHWKEGRBCxR2kdio7QhaRD1Y7EBq43UWNKReJbzDgB0hfBUHCEZMoBmI-rLxNvBD-FGJu79xG0RrnzyYeLU5akLufBDWzSJfZ6KMIOcijn5_lw8ib7P_OL2PBbfPrz_ev5JXnz5-Pn87EIGjXqSvkWjDdqIBJVtIjLFoGJVRzKaWkseCC1FxZWqdaxRAWuOFlHZumkaOhbvVu_1odlzG3iYku_dder2Pt240Xfu72Tortx2_OmWFalSs-DtrSCNPw6cJ7fvcuC-9wOPh-xUiQaAKvofVNVUlYrsjL75B92NhzTMP7FQxuoS9CJUKxXSmHPiePduBW6p0K0VurlCt1ToFvPr-wvfTfzubAZwBfIcDVtO965-wPpqHdrlaUx_pKVRxtiSfgGfkK7I</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1417954051</pqid></control><display><type>article</type><title>Pregnancy-related characteristics and breast cancer risk</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>SpringerLink Journals - AutoHoldings</source><creator>Brasky, Theodore M. ; Li, Yanli ; Jaworowicz, David J. ; Potischman, Nancy ; Ambrosone, Christine B. ; Hutson, Alan D. ; Nie, Jing ; Shields, Peter G. ; Trevisan, Maurizio ; Rudra, Carole B. ; Edge, Stephen B. ; Freudenheim, Jo L.</creator><creatorcontrib>Brasky, Theodore M. ; Li, Yanli ; Jaworowicz, David J. ; Potischman, Nancy ; Ambrosone, Christine B. ; Hutson, Alan D. ; Nie, Jing ; Shields, Peter G. ; Trevisan, Maurizio ; Rudra, Carole B. ; Edge, Stephen B. ; Freudenheim, Jo L.</creatorcontrib><description><![CDATA[Breast tissues undergo extensive physiologic changes during pregnancy, which may affect breast carcinogenesis. Gestational hypertension, preeclampsia/eclampsia, gestational diabetes, pregnancy weight gain, and nausea and vomiting (N&V) during pregnancy may be indicative of altered hormonal and metabolic profiles and could impact breast cancer risk. Here, we examined associations between these characteristics of a woman's pregnancy and her subsequent breast cancer risk. Participants were parous women that were recruited to a population-based case–control study (Western New York Exposures and Breast Cancer Study). Cases (n = 960), aged 35–79 years, had incident, primary, histologically confirmed breast cancer. Controls (n = 1,852) were randomly selected from motor vehicle records (<65 years) or Medicare rolls (≥65 years). Women were queried on their lifetime pregnancy experiences. Multivariable-adjusted logistic regression was used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs). N&V during pregnancy was inversely associated with breast cancer risk. Relative to those who never experienced N&V, ever experiencing N&V was associated with decreased risk (OR 0.69, 95 % CI 0.56–0.84) as were increased N&V severity (p trend < 0.001), longer duration (p trend < 0.01), and larger proportion of affected pregnancies (p trend < 0.0001) among women with ≥3 pregnancies. Associations were stronger for more recent pregnancies (<5 years). Findings did not differ by menopausal status or breast cancer subtype including estrogen receptor and HER2 expression status. Other pregnancy characteristics examined were not associated with risk. We observed strong inverse associations between pregnancy N&V and breast cancer risk. Replication of these findings and exploration of underlying mechanisms could provide important insight into breast cancer etiology and prevention.]]></description><identifier>ISSN: 0957-5243</identifier><identifier>ISSN: 1573-7225</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1007/s10552-013-0242-9</identifier><identifier>PMID: 23737027</identifier><identifier>CODEN: CCCNEN</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Adult ; Aged ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Breast Neoplasms - epidemiology ; Breast Neoplasms - pathology ; Cancer ; Cancer Research ; Case control studies ; Epidemiology ; Female ; Gestational diabetes ; Hematology ; Humans ; Middle Aged ; Nausea ; New York - epidemiology ; Oncology ; Original Paper ; Postmenopause ; Pregnancy ; Pregnancy Complications - epidemiology ; Public Health ; Risk Factors ; Tumors ; Vomiting ; Weight Gain</subject><ispartof>Cancer causes & control, 2013-09, Vol.24 (9), p.1675-1685</ispartof><rights>Springer Science+Business Media Dordrecht 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-ad275729f23069bf2e3fc1f68f3753d93a03293f1e6185f8210e5ef922198bbb3</citedby><cites>FETCH-LOGICAL-c525t-ad275729f23069bf2e3fc1f68f3753d93a03293f1e6185f8210e5ef922198bbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24717794$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24717794$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,27924,27925,41488,42557,51319,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23737027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brasky, Theodore M.</creatorcontrib><creatorcontrib>Li, Yanli</creatorcontrib><creatorcontrib>Jaworowicz, David J.</creatorcontrib><creatorcontrib>Potischman, Nancy</creatorcontrib><creatorcontrib>Ambrosone, Christine B.</creatorcontrib><creatorcontrib>Hutson, Alan D.</creatorcontrib><creatorcontrib>Nie, Jing</creatorcontrib><creatorcontrib>Shields, Peter G.</creatorcontrib><creatorcontrib>Trevisan, Maurizio</creatorcontrib><creatorcontrib>Rudra, Carole B.</creatorcontrib><creatorcontrib>Edge, Stephen B.</creatorcontrib><creatorcontrib>Freudenheim, Jo L.</creatorcontrib><title>Pregnancy-related characteristics and breast cancer risk</title><title>Cancer causes & control</title><addtitle>Cancer Causes Control</addtitle><addtitle>Cancer Causes Control</addtitle><description><![CDATA[Breast tissues undergo extensive physiologic changes during pregnancy, which may affect breast carcinogenesis. Gestational hypertension, preeclampsia/eclampsia, gestational diabetes, pregnancy weight gain, and nausea and vomiting (N&V) during pregnancy may be indicative of altered hormonal and metabolic profiles and could impact breast cancer risk. Here, we examined associations between these characteristics of a woman's pregnancy and her subsequent breast cancer risk. Participants were parous women that were recruited to a population-based case–control study (Western New York Exposures and Breast Cancer Study). Cases (n = 960), aged 35–79 years, had incident, primary, histologically confirmed breast cancer. Controls (n = 1,852) were randomly selected from motor vehicle records (<65 years) or Medicare rolls (≥65 years). Women were queried on their lifetime pregnancy experiences. Multivariable-adjusted logistic regression was used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs). N&V during pregnancy was inversely associated with breast cancer risk. Relative to those who never experienced N&V, ever experiencing N&V was associated with decreased risk (OR 0.69, 95 % CI 0.56–0.84) as were increased N&V severity (p trend < 0.001), longer duration (p trend < 0.01), and larger proportion of affected pregnancies (p trend < 0.0001) among women with ≥3 pregnancies. Associations were stronger for more recent pregnancies (<5 years). Findings did not differ by menopausal status or breast cancer subtype including estrogen receptor and HER2 expression status. Other pregnancy characteristics examined were not associated with risk. We observed strong inverse associations between pregnancy N&V and breast cancer risk. Replication of these findings and exploration of underlying mechanisms could provide important insight into breast cancer etiology and prevention.]]></description><subject>Adult</subject><subject>Aged</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Case control studies</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gestational diabetes</subject><subject>Hematology</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Nausea</subject><subject>New York - epidemiology</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Postmenopause</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Public Health</subject><subject>Risk Factors</subject><subject>Tumors</subject><subject>Vomiting</subject><subject>Weight Gain</subject><issn>0957-5243</issn><issn>1573-7225</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1v1DAQhi0EokvhB3AAReLCxe14Jo7jC1JV8SVVogc4W44z3mbJJsXOIvXfkyilFA4VJx_eZx57_ArxUsGJAjCnWYHWKEGRBCxR2kdio7QhaRD1Y7EBq43UWNKReJbzDgB0hfBUHCEZMoBmI-rLxNvBD-FGJu79xG0RrnzyYeLU5akLufBDWzSJfZ6KMIOcijn5_lw8ib7P_OL2PBbfPrz_ev5JXnz5-Pn87EIGjXqSvkWjDdqIBJVtIjLFoGJVRzKaWkseCC1FxZWqdaxRAWuOFlHZumkaOhbvVu_1odlzG3iYku_dder2Pt240Xfu72Tortx2_OmWFalSs-DtrSCNPw6cJ7fvcuC-9wOPh-xUiQaAKvofVNVUlYrsjL75B92NhzTMP7FQxuoS9CJUKxXSmHPiePduBW6p0K0VurlCt1ToFvPr-wvfTfzubAZwBfIcDVtO965-wPpqHdrlaUx_pKVRxtiSfgGfkK7I</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Brasky, Theodore M.</creator><creator>Li, Yanli</creator><creator>Jaworowicz, David J.</creator><creator>Potischman, Nancy</creator><creator>Ambrosone, Christine B.</creator><creator>Hutson, Alan D.</creator><creator>Nie, Jing</creator><creator>Shields, Peter G.</creator><creator>Trevisan, Maurizio</creator><creator>Rudra, Carole B.</creator><creator>Edge, Stephen B.</creator><creator>Freudenheim, Jo L.</creator><general>Springer</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20130901</creationdate><title>Pregnancy-related characteristics and breast cancer risk</title><author>Brasky, Theodore M. ; Li, Yanli ; Jaworowicz, David J. ; Potischman, Nancy ; Ambrosone, Christine B. ; Hutson, Alan D. ; Nie, Jing ; Shields, Peter G. ; Trevisan, Maurizio ; Rudra, Carole B. ; Edge, Stephen B. ; Freudenheim, Jo L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-ad275729f23069bf2e3fc1f68f3753d93a03293f1e6185f8210e5ef922198bbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Case control studies</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gestational diabetes</topic><topic>Hematology</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Nausea</topic><topic>New York - epidemiology</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Postmenopause</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Public Health</topic><topic>Risk Factors</topic><topic>Tumors</topic><topic>Vomiting</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brasky, Theodore M.</creatorcontrib><creatorcontrib>Li, Yanli</creatorcontrib><creatorcontrib>Jaworowicz, David J.</creatorcontrib><creatorcontrib>Potischman, Nancy</creatorcontrib><creatorcontrib>Ambrosone, Christine B.</creatorcontrib><creatorcontrib>Hutson, Alan D.</creatorcontrib><creatorcontrib>Nie, Jing</creatorcontrib><creatorcontrib>Shields, Peter G.</creatorcontrib><creatorcontrib>Trevisan, Maurizio</creatorcontrib><creatorcontrib>Rudra, Carole B.</creatorcontrib><creatorcontrib>Edge, Stephen B.</creatorcontrib><creatorcontrib>Freudenheim, Jo L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer causes & control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brasky, Theodore M.</au><au>Li, Yanli</au><au>Jaworowicz, David J.</au><au>Potischman, Nancy</au><au>Ambrosone, Christine B.</au><au>Hutson, Alan D.</au><au>Nie, Jing</au><au>Shields, Peter G.</au><au>Trevisan, Maurizio</au><au>Rudra, Carole B.</au><au>Edge, Stephen B.</au><au>Freudenheim, Jo L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy-related characteristics and breast cancer risk</atitle><jtitle>Cancer causes & control</jtitle><stitle>Cancer Causes Control</stitle><addtitle>Cancer Causes Control</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>24</volume><issue>9</issue><spage>1675</spage><epage>1685</epage><pages>1675-1685</pages><issn>0957-5243</issn><issn>1573-7225</issn><eissn>1573-7225</eissn><coden>CCCNEN</coden><abstract><![CDATA[Breast tissues undergo extensive physiologic changes during pregnancy, which may affect breast carcinogenesis. Gestational hypertension, preeclampsia/eclampsia, gestational diabetes, pregnancy weight gain, and nausea and vomiting (N&V) during pregnancy may be indicative of altered hormonal and metabolic profiles and could impact breast cancer risk. Here, we examined associations between these characteristics of a woman's pregnancy and her subsequent breast cancer risk. Participants were parous women that were recruited to a population-based case–control study (Western New York Exposures and Breast Cancer Study). Cases (n = 960), aged 35–79 years, had incident, primary, histologically confirmed breast cancer. Controls (n = 1,852) were randomly selected from motor vehicle records (<65 years) or Medicare rolls (≥65 years). Women were queried on their lifetime pregnancy experiences. Multivariable-adjusted logistic regression was used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs). N&V during pregnancy was inversely associated with breast cancer risk. Relative to those who never experienced N&V, ever experiencing N&V was associated with decreased risk (OR 0.69, 95 % CI 0.56–0.84) as were increased N&V severity (p trend < 0.001), longer duration (p trend < 0.01), and larger proportion of affected pregnancies (p trend < 0.0001) among women with ≥3 pregnancies. Associations were stronger for more recent pregnancies (<5 years). Findings did not differ by menopausal status or breast cancer subtype including estrogen receptor and HER2 expression status. Other pregnancy characteristics examined were not associated with risk. We observed strong inverse associations between pregnancy N&V and breast cancer risk. Replication of these findings and exploration of underlying mechanisms could provide important insight into breast cancer etiology and prevention.]]></abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>23737027</pmid><doi>10.1007/s10552-013-0242-9</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - pathology Cancer Cancer Research Case control studies Epidemiology Female Gestational diabetes Hematology Humans Middle Aged Nausea New York - epidemiology Oncology Original Paper Postmenopause Pregnancy Pregnancy Complications - epidemiology Public Health Risk Factors Tumors Vomiting Weight Gain |
| title | Pregnancy-related characteristics and breast cancer risk |
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