Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course
Genetic loci for body mass index (BMI) in adolescence and young adulthood, a period of high risk for weight gain, are understudied, yet may yield important insight into the etiology of obesity and early intervention. To identify novel genetic loci and examine the influence of known loci on BMI durin...
Gespeichert in:
| Veröffentlicht in: | Human molecular genetics 2013-09, Vol.22 (17), p.3597-3607 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3607 |
|---|---|
| container_issue | 17 |
| container_start_page | 3597 |
| container_title | Human molecular genetics |
| container_volume | 22 |
| creator | Graff, Mariaelisa Ngwa, Julius S Workalemahu, Tsegaselassie Homuth, Georg Schipf, Sabine Teumer, Alexander Völzke, Henry Wallaschofski, Henri Abecasis, Goncalo R Edward, Lakatta Francesco, Cucca Sanna, Serena Scheet, Paul Schlessinger, David Sidore, Carlo Xiao, Xiangjun Wang, Zhaoming Chanock, Stephen J Jacobs, Kevin B Hayes, Richard B Hu, Frank Van Dam, Rob M Crout, Richard J Marazita, Mary L Shaffer, John R Atwood, Larry D Fox, Caroline S Heard-Costa, Nancy L White, Charles Choh, Audrey C Czerwinski, Stefan A Demerath, Ellen W Dyer, Thomas D Towne, Bradford Amin, Najaf Oostra, Ben A Van Duijn, Cornelia M Zillikens, M Carola Esko, Tõnu Nelis, Mari Nikopensius, Tit Metspalu, Andres Strachan, David P Monda, Keri Qi, Lu North, Kari E Cupples, L Adrienne Gordon-Larsen, Penny Berndt, Sonja I |
| description | Genetic loci for body mass index (BMI) in adolescence and young adulthood, a period of high risk for weight gain, are understudied, yet may yield important insight into the etiology of obesity and early intervention. To identify novel genetic loci and examine the influence of known loci on BMI during this critical time period in late adolescence and early adulthood, we performed a two-stage meta-analysis using 14 genome-wide association studies in populations of European ancestry with data on BMI between ages 16 and 25 in up to 29 880 individuals. We identified seven independent loci (P < 5.0 × 10⁻⁸) near FTO (P = 3.72 × 10⁻²³), TMEM18 (P = 3.24 × 10⁻¹⁷), MC4R (P = 4.41 × 10⁻¹⁷), TNNI3K (P = 4.32 × 10⁻¹¹), SEC16B (P = 6.24 × 10⁻⁹), GNPDA2 (P = 1.11 × 10⁻⁸) and POMC (P = 4.94 × 10⁻⁸) as well as a potential secondary signal at the POMC locus (rs2118404, P = 2.4 × 10⁻⁵ after conditioning on the established single-nucleotide polymorphism at this locus) in adolescents and young adults. To evaluate the impact of the established genetic loci on BMI at these young ages, we examined differences between the effect sizes of 32 published BMI loci in European adult populations (aged 18-90) and those observed in our adolescent and young adult meta-analysis. Four loci (near PRKD1, TNNI3K, SEC16B and CADM2) had larger effects and one locus (near SH2B1) had a smaller effect on BMI during adolescence and young adulthood compared with older adults (P < 0.05). These results suggest that genetic loci for BMI can vary in their effects across the life course, underlying the importance of evaluating BMI at different ages. |
| doi_str_mv | 10.1093/hmg/ddt205 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3736869</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1419342233</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-5641a8d2e5e605e2716cde0a1fc57fb4704ebd85cf81978f04f35fc6d2b6f9c73</originalsourceid><addsrcrecordid>eNqNkc9u1DAQxi1ERbcLFx4A-YiQQv0vTnJBolVbKrXiAmfLa4-zRk5cbGfRvkMfGrdbKrhxGmm-33yamQ-ht5R8pGTgp9tpPLW2MNK-QCsqJGkY6flLtCKDFI0ciDxGJzn_IIRKwbtX6JhxKQfeshW6v4I5TtD88hawnnXYZ59xdPjs9hr7GWsbA2QDc8lVtngfl3ms3SXURoId6FAFa33xsU7XkezHbam1RFy2gME5MOXRcoQZijc4RONx3EF6BIJ3gE1cUobX6MhVP3jzVNfo--XFt_Mvzc3Xq-vzzzeNEZSWppWC6t4yaEGSFlhHpbFANHWm7dxGdETAxvatcT0dut4R4XjrjLRsI91gOr5Gnw6-d8tmAvtwXdJB3SU_6bRXUXv1rzL7rRrjTvGOy75-bo3ePxmk-HOBXNTk65NC0DPEJSsquCCMSNr9B0oHLhjjvKIfDqhJMecE7nkjStRD0qomrQ5JV_jd3zc8o3-i5b8B_5Cocg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1419342233</pqid></control><display><type>article</type><title>Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Graff, Mariaelisa ; Ngwa, Julius S ; Workalemahu, Tsegaselassie ; Homuth, Georg ; Schipf, Sabine ; Teumer, Alexander ; Völzke, Henry ; Wallaschofski, Henri ; Abecasis, Goncalo R ; Edward, Lakatta ; Francesco, Cucca ; Sanna, Serena ; Scheet, Paul ; Schlessinger, David ; Sidore, Carlo ; Xiao, Xiangjun ; Wang, Zhaoming ; Chanock, Stephen J ; Jacobs, Kevin B ; Hayes, Richard B ; Hu, Frank ; Van Dam, Rob M ; Crout, Richard J ; Marazita, Mary L ; Shaffer, John R ; Atwood, Larry D ; Fox, Caroline S ; Heard-Costa, Nancy L ; White, Charles ; Choh, Audrey C ; Czerwinski, Stefan A ; Demerath, Ellen W ; Dyer, Thomas D ; Towne, Bradford ; Amin, Najaf ; Oostra, Ben A ; Van Duijn, Cornelia M ; Zillikens, M Carola ; Esko, Tõnu ; Nelis, Mari ; Nikopensius, Tit ; Metspalu, Andres ; Strachan, David P ; Monda, Keri ; Qi, Lu ; North, Kari E ; Cupples, L Adrienne ; Gordon-Larsen, Penny ; Berndt, Sonja I</creator><creatorcontrib>Graff, Mariaelisa ; Ngwa, Julius S ; Workalemahu, Tsegaselassie ; Homuth, Georg ; Schipf, Sabine ; Teumer, Alexander ; Völzke, Henry ; Wallaschofski, Henri ; Abecasis, Goncalo R ; Edward, Lakatta ; Francesco, Cucca ; Sanna, Serena ; Scheet, Paul ; Schlessinger, David ; Sidore, Carlo ; Xiao, Xiangjun ; Wang, Zhaoming ; Chanock, Stephen J ; Jacobs, Kevin B ; Hayes, Richard B ; Hu, Frank ; Van Dam, Rob M ; Crout, Richard J ; Marazita, Mary L ; Shaffer, John R ; Atwood, Larry D ; Fox, Caroline S ; Heard-Costa, Nancy L ; White, Charles ; Choh, Audrey C ; Czerwinski, Stefan A ; Demerath, Ellen W ; Dyer, Thomas D ; Towne, Bradford ; Amin, Najaf ; Oostra, Ben A ; Van Duijn, Cornelia M ; Zillikens, M Carola ; Esko, Tõnu ; Nelis, Mari ; Nikopensius, Tit ; Metspalu, Andres ; Strachan, David P ; Monda, Keri ; Qi, Lu ; North, Kari E ; Cupples, L Adrienne ; Gordon-Larsen, Penny ; Berndt, Sonja I ; GIANT Consortium ; The GIANT Consortium</creatorcontrib><description>Genetic loci for body mass index (BMI) in adolescence and young adulthood, a period of high risk for weight gain, are understudied, yet may yield important insight into the etiology of obesity and early intervention. To identify novel genetic loci and examine the influence of known loci on BMI during this critical time period in late adolescence and early adulthood, we performed a two-stage meta-analysis using 14 genome-wide association studies in populations of European ancestry with data on BMI between ages 16 and 25 in up to 29 880 individuals. We identified seven independent loci (P < 5.0 × 10⁻⁸) near FTO (P = 3.72 × 10⁻²³), TMEM18 (P = 3.24 × 10⁻¹⁷), MC4R (P = 4.41 × 10⁻¹⁷), TNNI3K (P = 4.32 × 10⁻¹¹), SEC16B (P = 6.24 × 10⁻⁹), GNPDA2 (P = 1.11 × 10⁻⁸) and POMC (P = 4.94 × 10⁻⁸) as well as a potential secondary signal at the POMC locus (rs2118404, P = 2.4 × 10⁻⁵ after conditioning on the established single-nucleotide polymorphism at this locus) in adolescents and young adults. To evaluate the impact of the established genetic loci on BMI at these young ages, we examined differences between the effect sizes of 32 published BMI loci in European adult populations (aged 18-90) and those observed in our adolescent and young adult meta-analysis. Four loci (near PRKD1, TNNI3K, SEC16B and CADM2) had larger effects and one locus (near SH2B1) had a smaller effect on BMI during adolescence and young adulthood compared with older adults (P < 0.05). These results suggest that genetic loci for BMI can vary in their effects across the life course, underlying the importance of evaluating BMI at different ages.</description><identifier>ISSN: 0964-6906</identifier><identifier>EISSN: 1460-2083</identifier><identifier>DOI: 10.1093/hmg/ddt205</identifier><identifier>PMID: 23669352</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Association Studies ; Body Mass Index ; Cohort Studies ; European Continental Ancestry Group - genetics ; Genetic Loci ; Genome-Wide Association Study ; Humans ; Middle Aged ; Polymorphism, Single Nucleotide ; Weight Gain - genetics ; Young Adult</subject><ispartof>Human molecular genetics, 2013-09, Vol.22 (17), p.3597-3607</ispartof><rights>The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-5641a8d2e5e605e2716cde0a1fc57fb4704ebd85cf81978f04f35fc6d2b6f9c73</citedby><cites>FETCH-LOGICAL-c411t-5641a8d2e5e605e2716cde0a1fc57fb4704ebd85cf81978f04f35fc6d2b6f9c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23669352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Graff, Mariaelisa</creatorcontrib><creatorcontrib>Ngwa, Julius S</creatorcontrib><creatorcontrib>Workalemahu, Tsegaselassie</creatorcontrib><creatorcontrib>Homuth, Georg</creatorcontrib><creatorcontrib>Schipf, Sabine</creatorcontrib><creatorcontrib>Teumer, Alexander</creatorcontrib><creatorcontrib>Völzke, Henry</creatorcontrib><creatorcontrib>Wallaschofski, Henri</creatorcontrib><creatorcontrib>Abecasis, Goncalo R</creatorcontrib><creatorcontrib>Edward, Lakatta</creatorcontrib><creatorcontrib>Francesco, Cucca</creatorcontrib><creatorcontrib>Sanna, Serena</creatorcontrib><creatorcontrib>Scheet, Paul</creatorcontrib><creatorcontrib>Schlessinger, David</creatorcontrib><creatorcontrib>Sidore, Carlo</creatorcontrib><creatorcontrib>Xiao, Xiangjun</creatorcontrib><creatorcontrib>Wang, Zhaoming</creatorcontrib><creatorcontrib>Chanock, Stephen J</creatorcontrib><creatorcontrib>Jacobs, Kevin B</creatorcontrib><creatorcontrib>Hayes, Richard B</creatorcontrib><creatorcontrib>Hu, Frank</creatorcontrib><creatorcontrib>Van Dam, Rob M</creatorcontrib><creatorcontrib>Crout, Richard J</creatorcontrib><creatorcontrib>Marazita, Mary L</creatorcontrib><creatorcontrib>Shaffer, John R</creatorcontrib><creatorcontrib>Atwood, Larry D</creatorcontrib><creatorcontrib>Fox, Caroline S</creatorcontrib><creatorcontrib>Heard-Costa, Nancy L</creatorcontrib><creatorcontrib>White, Charles</creatorcontrib><creatorcontrib>Choh, Audrey C</creatorcontrib><creatorcontrib>Czerwinski, Stefan A</creatorcontrib><creatorcontrib>Demerath, Ellen W</creatorcontrib><creatorcontrib>Dyer, Thomas D</creatorcontrib><creatorcontrib>Towne, Bradford</creatorcontrib><creatorcontrib>Amin, Najaf</creatorcontrib><creatorcontrib>Oostra, Ben A</creatorcontrib><creatorcontrib>Van Duijn, Cornelia M</creatorcontrib><creatorcontrib>Zillikens, M Carola</creatorcontrib><creatorcontrib>Esko, Tõnu</creatorcontrib><creatorcontrib>Nelis, Mari</creatorcontrib><creatorcontrib>Nikopensius, Tit</creatorcontrib><creatorcontrib>Metspalu, Andres</creatorcontrib><creatorcontrib>Strachan, David P</creatorcontrib><creatorcontrib>Monda, Keri</creatorcontrib><creatorcontrib>Qi, Lu</creatorcontrib><creatorcontrib>North, Kari E</creatorcontrib><creatorcontrib>Cupples, L Adrienne</creatorcontrib><creatorcontrib>Gordon-Larsen, Penny</creatorcontrib><creatorcontrib>Berndt, Sonja I</creatorcontrib><creatorcontrib>GIANT Consortium</creatorcontrib><creatorcontrib>The GIANT Consortium</creatorcontrib><title>Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course</title><title>Human molecular genetics</title><addtitle>Hum Mol Genet</addtitle><description>Genetic loci for body mass index (BMI) in adolescence and young adulthood, a period of high risk for weight gain, are understudied, yet may yield important insight into the etiology of obesity and early intervention. To identify novel genetic loci and examine the influence of known loci on BMI during this critical time period in late adolescence and early adulthood, we performed a two-stage meta-analysis using 14 genome-wide association studies in populations of European ancestry with data on BMI between ages 16 and 25 in up to 29 880 individuals. We identified seven independent loci (P < 5.0 × 10⁻⁸) near FTO (P = 3.72 × 10⁻²³), TMEM18 (P = 3.24 × 10⁻¹⁷), MC4R (P = 4.41 × 10⁻¹⁷), TNNI3K (P = 4.32 × 10⁻¹¹), SEC16B (P = 6.24 × 10⁻⁹), GNPDA2 (P = 1.11 × 10⁻⁸) and POMC (P = 4.94 × 10⁻⁸) as well as a potential secondary signal at the POMC locus (rs2118404, P = 2.4 × 10⁻⁵ after conditioning on the established single-nucleotide polymorphism at this locus) in adolescents and young adults. To evaluate the impact of the established genetic loci on BMI at these young ages, we examined differences between the effect sizes of 32 published BMI loci in European adult populations (aged 18-90) and those observed in our adolescent and young adult meta-analysis. Four loci (near PRKD1, TNNI3K, SEC16B and CADM2) had larger effects and one locus (near SH2B1) had a smaller effect on BMI during adolescence and young adulthood compared with older adults (P < 0.05). These results suggest that genetic loci for BMI can vary in their effects across the life course, underlying the importance of evaluating BMI at different ages.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Association Studies</subject><subject>Body Mass Index</subject><subject>Cohort Studies</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Genetic Loci</subject><subject>Genome-Wide Association Study</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Weight Gain - genetics</subject><subject>Young Adult</subject><issn>0964-6906</issn><issn>1460-2083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQxi1ERbcLFx4A-YiQQv0vTnJBolVbKrXiAmfLa4-zRk5cbGfRvkMfGrdbKrhxGmm-33yamQ-ht5R8pGTgp9tpPLW2MNK-QCsqJGkY6flLtCKDFI0ciDxGJzn_IIRKwbtX6JhxKQfeshW6v4I5TtD88hawnnXYZ59xdPjs9hr7GWsbA2QDc8lVtngfl3ms3SXURoId6FAFa33xsU7XkezHbam1RFy2gME5MOXRcoQZijc4RONx3EF6BIJ3gE1cUobX6MhVP3jzVNfo--XFt_Mvzc3Xq-vzzzeNEZSWppWC6t4yaEGSFlhHpbFANHWm7dxGdETAxvatcT0dut4R4XjrjLRsI91gOr5Gnw6-d8tmAvtwXdJB3SU_6bRXUXv1rzL7rRrjTvGOy75-bo3ePxmk-HOBXNTk65NC0DPEJSsquCCMSNr9B0oHLhjjvKIfDqhJMecE7nkjStRD0qomrQ5JV_jd3zc8o3-i5b8B_5Cocg</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Graff, Mariaelisa</creator><creator>Ngwa, Julius S</creator><creator>Workalemahu, Tsegaselassie</creator><creator>Homuth, Georg</creator><creator>Schipf, Sabine</creator><creator>Teumer, Alexander</creator><creator>Völzke, Henry</creator><creator>Wallaschofski, Henri</creator><creator>Abecasis, Goncalo R</creator><creator>Edward, Lakatta</creator><creator>Francesco, Cucca</creator><creator>Sanna, Serena</creator><creator>Scheet, Paul</creator><creator>Schlessinger, David</creator><creator>Sidore, Carlo</creator><creator>Xiao, Xiangjun</creator><creator>Wang, Zhaoming</creator><creator>Chanock, Stephen J</creator><creator>Jacobs, Kevin B</creator><creator>Hayes, Richard B</creator><creator>Hu, Frank</creator><creator>Van Dam, Rob M</creator><creator>Crout, Richard J</creator><creator>Marazita, Mary L</creator><creator>Shaffer, John R</creator><creator>Atwood, Larry D</creator><creator>Fox, Caroline S</creator><creator>Heard-Costa, Nancy L</creator><creator>White, Charles</creator><creator>Choh, Audrey C</creator><creator>Czerwinski, Stefan A</creator><creator>Demerath, Ellen W</creator><creator>Dyer, Thomas D</creator><creator>Towne, Bradford</creator><creator>Amin, Najaf</creator><creator>Oostra, Ben A</creator><creator>Van Duijn, Cornelia M</creator><creator>Zillikens, M Carola</creator><creator>Esko, Tõnu</creator><creator>Nelis, Mari</creator><creator>Nikopensius, Tit</creator><creator>Metspalu, Andres</creator><creator>Strachan, David P</creator><creator>Monda, Keri</creator><creator>Qi, Lu</creator><creator>North, Kari E</creator><creator>Cupples, L Adrienne</creator><creator>Gordon-Larsen, Penny</creator><creator>Berndt, Sonja I</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20130901</creationdate><title>Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course</title><author>Graff, Mariaelisa ; Ngwa, Julius S ; Workalemahu, Tsegaselassie ; Homuth, Georg ; Schipf, Sabine ; Teumer, Alexander ; Völzke, Henry ; Wallaschofski, Henri ; Abecasis, Goncalo R ; Edward, Lakatta ; Francesco, Cucca ; Sanna, Serena ; Scheet, Paul ; Schlessinger, David ; Sidore, Carlo ; Xiao, Xiangjun ; Wang, Zhaoming ; Chanock, Stephen J ; Jacobs, Kevin B ; Hayes, Richard B ; Hu, Frank ; Van Dam, Rob M ; Crout, Richard J ; Marazita, Mary L ; Shaffer, John R ; Atwood, Larry D ; Fox, Caroline S ; Heard-Costa, Nancy L ; White, Charles ; Choh, Audrey C ; Czerwinski, Stefan A ; Demerath, Ellen W ; Dyer, Thomas D ; Towne, Bradford ; Amin, Najaf ; Oostra, Ben A ; Van Duijn, Cornelia M ; Zillikens, M Carola ; Esko, Tõnu ; Nelis, Mari ; Nikopensius, Tit ; Metspalu, Andres ; Strachan, David P ; Monda, Keri ; Qi, Lu ; North, Kari E ; Cupples, L Adrienne ; Gordon-Larsen, Penny ; Berndt, Sonja I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-5641a8d2e5e605e2716cde0a1fc57fb4704ebd85cf81978f04f35fc6d2b6f9c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Association Studies</topic><topic>Body Mass Index</topic><topic>Cohort Studies</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Genetic Loci</topic><topic>Genome-Wide Association Study</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Weight Gain - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graff, Mariaelisa</creatorcontrib><creatorcontrib>Ngwa, Julius S</creatorcontrib><creatorcontrib>Workalemahu, Tsegaselassie</creatorcontrib><creatorcontrib>Homuth, Georg</creatorcontrib><creatorcontrib>Schipf, Sabine</creatorcontrib><creatorcontrib>Teumer, Alexander</creatorcontrib><creatorcontrib>Völzke, Henry</creatorcontrib><creatorcontrib>Wallaschofski, Henri</creatorcontrib><creatorcontrib>Abecasis, Goncalo R</creatorcontrib><creatorcontrib>Edward, Lakatta</creatorcontrib><creatorcontrib>Francesco, Cucca</creatorcontrib><creatorcontrib>Sanna, Serena</creatorcontrib><creatorcontrib>Scheet, Paul</creatorcontrib><creatorcontrib>Schlessinger, David</creatorcontrib><creatorcontrib>Sidore, Carlo</creatorcontrib><creatorcontrib>Xiao, Xiangjun</creatorcontrib><creatorcontrib>Wang, Zhaoming</creatorcontrib><creatorcontrib>Chanock, Stephen J</creatorcontrib><creatorcontrib>Jacobs, Kevin B</creatorcontrib><creatorcontrib>Hayes, Richard B</creatorcontrib><creatorcontrib>Hu, Frank</creatorcontrib><creatorcontrib>Van Dam, Rob M</creatorcontrib><creatorcontrib>Crout, Richard J</creatorcontrib><creatorcontrib>Marazita, Mary L</creatorcontrib><creatorcontrib>Shaffer, John R</creatorcontrib><creatorcontrib>Atwood, Larry D</creatorcontrib><creatorcontrib>Fox, Caroline S</creatorcontrib><creatorcontrib>Heard-Costa, Nancy L</creatorcontrib><creatorcontrib>White, Charles</creatorcontrib><creatorcontrib>Choh, Audrey C</creatorcontrib><creatorcontrib>Czerwinski, Stefan A</creatorcontrib><creatorcontrib>Demerath, Ellen W</creatorcontrib><creatorcontrib>Dyer, Thomas D</creatorcontrib><creatorcontrib>Towne, Bradford</creatorcontrib><creatorcontrib>Amin, Najaf</creatorcontrib><creatorcontrib>Oostra, Ben A</creatorcontrib><creatorcontrib>Van Duijn, Cornelia M</creatorcontrib><creatorcontrib>Zillikens, M Carola</creatorcontrib><creatorcontrib>Esko, Tõnu</creatorcontrib><creatorcontrib>Nelis, Mari</creatorcontrib><creatorcontrib>Nikopensius, Tit</creatorcontrib><creatorcontrib>Metspalu, Andres</creatorcontrib><creatorcontrib>Strachan, David P</creatorcontrib><creatorcontrib>Monda, Keri</creatorcontrib><creatorcontrib>Qi, Lu</creatorcontrib><creatorcontrib>North, Kari E</creatorcontrib><creatorcontrib>Cupples, L Adrienne</creatorcontrib><creatorcontrib>Gordon-Larsen, Penny</creatorcontrib><creatorcontrib>Berndt, Sonja I</creatorcontrib><creatorcontrib>GIANT Consortium</creatorcontrib><creatorcontrib>The GIANT Consortium</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human molecular genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graff, Mariaelisa</au><au>Ngwa, Julius S</au><au>Workalemahu, Tsegaselassie</au><au>Homuth, Georg</au><au>Schipf, Sabine</au><au>Teumer, Alexander</au><au>Völzke, Henry</au><au>Wallaschofski, Henri</au><au>Abecasis, Goncalo R</au><au>Edward, Lakatta</au><au>Francesco, Cucca</au><au>Sanna, Serena</au><au>Scheet, Paul</au><au>Schlessinger, David</au><au>Sidore, Carlo</au><au>Xiao, Xiangjun</au><au>Wang, Zhaoming</au><au>Chanock, Stephen J</au><au>Jacobs, Kevin B</au><au>Hayes, Richard B</au><au>Hu, Frank</au><au>Van Dam, Rob M</au><au>Crout, Richard J</au><au>Marazita, Mary L</au><au>Shaffer, John R</au><au>Atwood, Larry D</au><au>Fox, Caroline S</au><au>Heard-Costa, Nancy L</au><au>White, Charles</au><au>Choh, Audrey C</au><au>Czerwinski, Stefan A</au><au>Demerath, Ellen W</au><au>Dyer, Thomas D</au><au>Towne, Bradford</au><au>Amin, Najaf</au><au>Oostra, Ben A</au><au>Van Duijn, Cornelia M</au><au>Zillikens, M Carola</au><au>Esko, Tõnu</au><au>Nelis, Mari</au><au>Nikopensius, Tit</au><au>Metspalu, Andres</au><au>Strachan, David P</au><au>Monda, Keri</au><au>Qi, Lu</au><au>North, Kari E</au><au>Cupples, L Adrienne</au><au>Gordon-Larsen, Penny</au><au>Berndt, Sonja I</au><aucorp>GIANT Consortium</aucorp><aucorp>The GIANT Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course</atitle><jtitle>Human molecular genetics</jtitle><addtitle>Hum Mol Genet</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>22</volume><issue>17</issue><spage>3597</spage><epage>3607</epage><pages>3597-3607</pages><issn>0964-6906</issn><eissn>1460-2083</eissn><abstract>Genetic loci for body mass index (BMI) in adolescence and young adulthood, a period of high risk for weight gain, are understudied, yet may yield important insight into the etiology of obesity and early intervention. To identify novel genetic loci and examine the influence of known loci on BMI during this critical time period in late adolescence and early adulthood, we performed a two-stage meta-analysis using 14 genome-wide association studies in populations of European ancestry with data on BMI between ages 16 and 25 in up to 29 880 individuals. We identified seven independent loci (P < 5.0 × 10⁻⁸) near FTO (P = 3.72 × 10⁻²³), TMEM18 (P = 3.24 × 10⁻¹⁷), MC4R (P = 4.41 × 10⁻¹⁷), TNNI3K (P = 4.32 × 10⁻¹¹), SEC16B (P = 6.24 × 10⁻⁹), GNPDA2 (P = 1.11 × 10⁻⁸) and POMC (P = 4.94 × 10⁻⁸) as well as a potential secondary signal at the POMC locus (rs2118404, P = 2.4 × 10⁻⁵ after conditioning on the established single-nucleotide polymorphism at this locus) in adolescents and young adults. To evaluate the impact of the established genetic loci on BMI at these young ages, we examined differences between the effect sizes of 32 published BMI loci in European adult populations (aged 18-90) and those observed in our adolescent and young adult meta-analysis. Four loci (near PRKD1, TNNI3K, SEC16B and CADM2) had larger effects and one locus (near SH2B1) had a smaller effect on BMI during adolescence and young adulthood compared with older adults (P < 0.05). These results suggest that genetic loci for BMI can vary in their effects across the life course, underlying the importance of evaluating BMI at different ages.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>23669352</pmid><doi>10.1093/hmg/ddt205</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0964-6906 |
| ispartof | Human molecular genetics, 2013-09, Vol.22 (17), p.3597-3607 |
| issn | 0964-6906 1460-2083 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3736869 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Age Factors Aged Aged, 80 and over Association Studies Body Mass Index Cohort Studies European Continental Ancestry Group - genetics Genetic Loci Genome-Wide Association Study Humans Middle Aged Polymorphism, Single Nucleotide Weight Gain - genetics Young Adult |
| title | Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T02%3A14%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genome-wide%20analysis%20of%20BMI%20in%20adolescents%20and%20young%20adults%20reveals%20additional%20insight%20into%20the%20effects%20of%20genetic%20loci%20over%20the%20life%20course&rft.jtitle=Human%20molecular%20genetics&rft.au=Graff,%20Mariaelisa&rft.aucorp=GIANT%20Consortium&rft.date=2013-09-01&rft.volume=22&rft.issue=17&rft.spage=3597&rft.epage=3607&rft.pages=3597-3607&rft.issn=0964-6906&rft.eissn=1460-2083&rft_id=info:doi/10.1093/hmg/ddt205&rft_dat=%3Cproquest_pubme%3E1419342233%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1419342233&rft_id=info:pmid/23669352&rfr_iscdi=true |