Membrane Fusion: Grappling with SNARE and SM Proteins

The two universally required components of the intracellular membrane fusion machinery, SNARE and SM (Sec1/Munc18-like) proteins, play complementary roles in fusion. Vesicular and target membrane-localized SNARE proteins zipper up into an α-helical bundle that pulls the two membranes tightly togethe...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2009-01, Vol.323 (5913), p.474-477
Hauptverfasser:	Südhof, Thomas C, Rothman, James E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Cellular biology Intracellular membranes Membrane Fusion Membranes Munc18 Proteins - chemistry Munc18 Proteins - metabolism Nerve Tissue Proteins - metabolism Neurons P branes Physiological regulation Protein Binding Protein Conformation Protein folding Protein Structure, Quaternary Protein Structure, Tertiary Proteins Qa-SNARE Proteins - chemistry Qa-SNARE Proteins - metabolism Review SNARE proteins SNARE Proteins - chemistry SNARE Proteins - metabolism String theory Synapses Synapses - physiology Synaptic Transmission Synaptic Vesicles - physiology Synaptotagmins Synaptotagmins - metabolism Thermodynamics Vesicular Transport Proteins - chemistry Vesicular Transport Proteins - metabolism
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