Early life risk factors of being overweight at 10 years of age: results of the German birth cohorts GINIplus and LISAplus

Objective: To develop a prediction model that quantifies the risk of being overweight at 10 years of age. Subjects/Methods: In total, 3121 participants from the GINIplus (German Infant Nutritional Intervention plus environmental and genetic influences on allergy development) and LISAplus (Influences...

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Veröffentlicht in:European journal of clinical nutrition 2013-08, Vol.67 (8), p.855-862
Hauptverfasser: Pei, Z, Flexeder, C, Fuertes, E, Thiering, E, Koletzko, B, Cramer, C, Berdel, D, Lehmann, I, Bauer, C-P, Heinrich, J
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container_end_page 862
container_issue 8
container_start_page 855
container_title European journal of clinical nutrition
container_volume 67
creator Pei, Z
Flexeder, C
Fuertes, E
Thiering, E
Koletzko, B
Cramer, C
Berdel, D
Lehmann, I
Bauer, C-P
Heinrich, J
description Objective: To develop a prediction model that quantifies the risk of being overweight at 10 years of age. Subjects/Methods: In total, 3121 participants from the GINIplus (German Infant Nutritional Intervention plus environmental and genetic influences on allergy development) and LISAplus (Influences of Lifestyle-Related Factors on the Immune System and the Development of Allergies in Childhood plus Air Pollution and Genetics) German birth cohorts were recruited. We predicted standardized body mass index (BMI) at 10 years of age using standardized BMIs from birth to 5 years. Parental education, family income and maternal smoking during pregnancy were considered as covariates. Linear and logistic regression models were used to evaluate the impact of risk factors on BMI and on being overweight at 10 years of age, respectively. Results: Birth weight, standardized BMI at 5 years (60–64 months) ( β =0.77; 95% confidence interval (CI): 0.73–0.81) and maternal smoking during pregnancy were positively associated with standardized BMI at 10 years of age. Standardized BMI and overweight at 5 years were strongest predictors of being overweight at 10 years. Conversely, high parental education conferred a protective effect ( β =−0.15; 95% CI: −0.29 to −0.01). Being overweight at 5 years (60–64 months) increased the risk of being overweight at 10 years of age with odds ratios above 10. Among children who were predicted to be overweight at 10 years, cross-validation results showed that 76.8% of female subjects and 68.1% of male subjects would be overweight at 10 years of age. Conclusion: BMI and being overweight at 5 years of age are strong predictors of being overweight at 10 years of age. The effectiveness of targeted interventions in children who are overweight at 5 years of age should be explored.
doi_str_mv 10.1038/ejcn.2013.80
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Subjects/Methods: In total, 3121 participants from the GINIplus (German Infant Nutritional Intervention plus environmental and genetic influences on allergy development) and LISAplus (Influences of Lifestyle-Related Factors on the Immune System and the Development of Allergies in Childhood plus Air Pollution and Genetics) German birth cohorts were recruited. We predicted standardized body mass index (BMI) at 10 years of age using standardized BMIs from birth to 5 years. Parental education, family income and maternal smoking during pregnancy were considered as covariates. Linear and logistic regression models were used to evaluate the impact of risk factors on BMI and on being overweight at 10 years of age, respectively. Results: Birth weight, standardized BMI at 5 years (60–64 months) ( β =0.77; 95% confidence interval (CI): 0.73–0.81) and maternal smoking during pregnancy were positively associated with standardized BMI at 10 years of age. Standardized BMI and overweight at 5 years were strongest predictors of being overweight at 10 years. Conversely, high parental education conferred a protective effect ( β =−0.15; 95% CI: −0.29 to −0.01). Being overweight at 5 years (60–64 months) increased the risk of being overweight at 10 years of age with odds ratios above 10. Among children who were predicted to be overweight at 10 years, cross-validation results showed that 76.8% of female subjects and 68.1% of male subjects would be overweight at 10 years of age. Conclusion: BMI and being overweight at 5 years of age are strong predictors of being overweight at 10 years of age. The effectiveness of targeted interventions in children who are overweight at 5 years of age should be explored.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2013.80</identifier><identifier>PMID: 23612517</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/1702/393 ; 692/700/1720 ; Age Factors ; Air pollution ; Allergies ; Biological and medical sciences ; Birth Weight ; Body Mass Index ; Child ; Child, Preschool ; Children &amp; youth ; Clinical Nutrition ; Cohort Studies ; Education ; Educational Status ; Epidemiology ; Feeding. Feeding behavior ; Female ; Females ; Fundamental and applied biological sciences. Psychology ; Genetics ; Germany ; Humans ; Immune system ; Infants ; Internal Medicine ; Male ; Medical sciences ; Medicine ; Medicine &amp; Public Health ; Metabolic Diseases ; Nutrition research ; Obesity ; Obesity - etiology ; Odds Ratio ; Original ; original-article ; Overweight - complications ; Parents ; Physiological aspects ; Prediction models ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prevalence studies (Epidemiology) ; Public Health ; Risk Factors ; Risk factors (Health) ; Sex Factors ; Smoking ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>European journal of clinical nutrition, 2013-08, Vol.67 (8), p.855-862</ispartof><rights>The Author(s) 2013</rights><rights>2014 INIST-CNRS</rights><rights>COPYRIGHT 2013 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 2013</rights><rights>Copyright © 2013 Macmillan Publishers Limited 2013 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c649t-30529033350ca1b013158ca58cdf44ea8391da2471bacba9d7410caddbfe98743</citedby><cites>FETCH-LOGICAL-c649t-30529033350ca1b013158ca58cdf44ea8391da2471bacba9d7410caddbfe98743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ejcn.2013.80$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ejcn.2013.80$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=27599024$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23612517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pei, Z</creatorcontrib><creatorcontrib>Flexeder, C</creatorcontrib><creatorcontrib>Fuertes, E</creatorcontrib><creatorcontrib>Thiering, E</creatorcontrib><creatorcontrib>Koletzko, B</creatorcontrib><creatorcontrib>Cramer, C</creatorcontrib><creatorcontrib>Berdel, D</creatorcontrib><creatorcontrib>Lehmann, I</creatorcontrib><creatorcontrib>Bauer, C-P</creatorcontrib><creatorcontrib>Heinrich, J</creatorcontrib><creatorcontrib>GINIplus and LISAplus Study Group</creatorcontrib><creatorcontrib>for the GINIplus and LISAplus Study Group</creatorcontrib><title>Early life risk factors of being overweight at 10 years of age: results of the German birth cohorts GINIplus and LISAplus</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Objective: To develop a prediction model that quantifies the risk of being overweight at 10 years of age. 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Standardized BMI and overweight at 5 years were strongest predictors of being overweight at 10 years. Conversely, high parental education conferred a protective effect ( β =−0.15; 95% CI: −0.29 to −0.01). Being overweight at 5 years (60–64 months) increased the risk of being overweight at 10 years of age with odds ratios above 10. Among children who were predicted to be overweight at 10 years, cross-validation results showed that 76.8% of female subjects and 68.1% of male subjects would be overweight at 10 years of age. Conclusion: BMI and being overweight at 5 years of age are strong predictors of being overweight at 10 years of age. The effectiveness of targeted interventions in children who are overweight at 5 years of age should be explored.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23612517</pmid><doi>10.1038/ejcn.2013.80</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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1476-5640
language eng
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subjects 692/499
692/699/1702/393
692/700/1720
Age Factors
Air pollution
Allergies
Biological and medical sciences
Birth Weight
Body Mass Index
Child
Child, Preschool
Children & youth
Clinical Nutrition
Cohort Studies
Education
Educational Status
Epidemiology
Feeding. Feeding behavior
Female
Females
Fundamental and applied biological sciences. Psychology
Genetics
Germany
Humans
Immune system
Infants
Internal Medicine
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Nutrition research
Obesity
Obesity - etiology
Odds Ratio
Original
original-article
Overweight - complications
Parents
Physiological aspects
Prediction models
Pregnancy
Prenatal Exposure Delayed Effects
Prevalence studies (Epidemiology)
Public Health
Risk Factors
Risk factors (Health)
Sex Factors
Smoking
Vertebrates: anatomy and physiology, studies on body, several organs or systems
title Early life risk factors of being overweight at 10 years of age: results of the German birth cohorts GINIplus and LISAplus
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