Early life risk factors of being overweight at 10 years of age: results of the German birth cohorts GINIplus and LISAplus
Objective: To develop a prediction model that quantifies the risk of being overweight at 10 years of age. Subjects/Methods: In total, 3121 participants from the GINIplus (German Infant Nutritional Intervention plus environmental and genetic influences on allergy development) and LISAplus (Influences...
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creator | Pei, Z Flexeder, C Fuertes, E Thiering, E Koletzko, B Cramer, C Berdel, D Lehmann, I Bauer, C-P Heinrich, J |
description | Objective:
To develop a prediction model that quantifies the risk of being overweight at 10 years of age.
Subjects/Methods:
In total, 3121 participants from the GINIplus (German Infant Nutritional Intervention plus environmental and genetic influences on allergy development) and LISAplus (Influences of Lifestyle-Related Factors on the Immune System and the Development of Allergies in Childhood plus Air Pollution and Genetics) German birth cohorts were recruited. We predicted standardized body mass index (BMI) at 10 years of age using standardized BMIs from birth to 5 years. Parental education, family income and maternal smoking during pregnancy were considered as covariates. Linear and logistic regression models were used to evaluate the impact of risk factors on BMI and on being overweight at 10 years of age, respectively.
Results:
Birth weight, standardized BMI at 5 years (60–64 months) (
β
=0.77; 95% confidence interval (CI): 0.73–0.81) and maternal smoking during pregnancy were positively associated with standardized BMI at 10 years of age. Standardized BMI and overweight at 5 years were strongest predictors of being overweight at 10 years. Conversely, high parental education conferred a protective effect (
β
=−0.15; 95% CI: −0.29 to −0.01). Being overweight at 5 years (60–64 months) increased the risk of being overweight at 10 years of age with odds ratios above 10. Among children who were predicted to be overweight at 10 years, cross-validation results showed that 76.8% of female subjects and 68.1% of male subjects would be overweight at 10 years of age.
Conclusion:
BMI and being overweight at 5 years of age are strong predictors of being overweight at 10 years of age. The effectiveness of targeted interventions in children who are overweight at 5 years of age should be explored. |
doi_str_mv | 10.1038/ejcn.2013.80 |
format | Article |
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To develop a prediction model that quantifies the risk of being overweight at 10 years of age.
Subjects/Methods:
In total, 3121 participants from the GINIplus (German Infant Nutritional Intervention plus environmental and genetic influences on allergy development) and LISAplus (Influences of Lifestyle-Related Factors on the Immune System and the Development of Allergies in Childhood plus Air Pollution and Genetics) German birth cohorts were recruited. We predicted standardized body mass index (BMI) at 10 years of age using standardized BMIs from birth to 5 years. Parental education, family income and maternal smoking during pregnancy were considered as covariates. Linear and logistic regression models were used to evaluate the impact of risk factors on BMI and on being overweight at 10 years of age, respectively.
Results:
Birth weight, standardized BMI at 5 years (60–64 months) (
β
=0.77; 95% confidence interval (CI): 0.73–0.81) and maternal smoking during pregnancy were positively associated with standardized BMI at 10 years of age. Standardized BMI and overweight at 5 years were strongest predictors of being overweight at 10 years. Conversely, high parental education conferred a protective effect (
β
=−0.15; 95% CI: −0.29 to −0.01). Being overweight at 5 years (60–64 months) increased the risk of being overweight at 10 years of age with odds ratios above 10. Among children who were predicted to be overweight at 10 years, cross-validation results showed that 76.8% of female subjects and 68.1% of male subjects would be overweight at 10 years of age.
Conclusion:
BMI and being overweight at 5 years of age are strong predictors of being overweight at 10 years of age. The effectiveness of targeted interventions in children who are overweight at 5 years of age should be explored.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2013.80</identifier><identifier>PMID: 23612517</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/1702/393 ; 692/700/1720 ; Age Factors ; Air pollution ; Allergies ; Biological and medical sciences ; Birth Weight ; Body Mass Index ; Child ; Child, Preschool ; Children & youth ; Clinical Nutrition ; Cohort Studies ; Education ; Educational Status ; Epidemiology ; Feeding. Feeding behavior ; Female ; Females ; Fundamental and applied biological sciences. Psychology ; Genetics ; Germany ; Humans ; Immune system ; Infants ; Internal Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Nutrition research ; Obesity ; Obesity - etiology ; Odds Ratio ; Original ; original-article ; Overweight - complications ; Parents ; Physiological aspects ; Prediction models ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prevalence studies (Epidemiology) ; Public Health ; Risk Factors ; Risk factors (Health) ; Sex Factors ; Smoking ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>European journal of clinical nutrition, 2013-08, Vol.67 (8), p.855-862</ispartof><rights>The Author(s) 2013</rights><rights>2014 INIST-CNRS</rights><rights>COPYRIGHT 2013 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 2013</rights><rights>Copyright © 2013 Macmillan Publishers Limited 2013 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c649t-30529033350ca1b013158ca58cdf44ea8391da2471bacba9d7410caddbfe98743</citedby><cites>FETCH-LOGICAL-c649t-30529033350ca1b013158ca58cdf44ea8391da2471bacba9d7410caddbfe98743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ejcn.2013.80$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ejcn.2013.80$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27599024$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23612517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pei, Z</creatorcontrib><creatorcontrib>Flexeder, C</creatorcontrib><creatorcontrib>Fuertes, E</creatorcontrib><creatorcontrib>Thiering, E</creatorcontrib><creatorcontrib>Koletzko, B</creatorcontrib><creatorcontrib>Cramer, C</creatorcontrib><creatorcontrib>Berdel, D</creatorcontrib><creatorcontrib>Lehmann, I</creatorcontrib><creatorcontrib>Bauer, C-P</creatorcontrib><creatorcontrib>Heinrich, J</creatorcontrib><creatorcontrib>GINIplus and LISAplus Study Group</creatorcontrib><creatorcontrib>for the GINIplus and LISAplus Study Group</creatorcontrib><title>Early life risk factors of being overweight at 10 years of age: results of the German birth cohorts GINIplus and LISAplus</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Objective:
To develop a prediction model that quantifies the risk of being overweight at 10 years of age.
Subjects/Methods:
In total, 3121 participants from the GINIplus (German Infant Nutritional Intervention plus environmental and genetic influences on allergy development) and LISAplus (Influences of Lifestyle-Related Factors on the Immune System and the Development of Allergies in Childhood plus Air Pollution and Genetics) German birth cohorts were recruited. We predicted standardized body mass index (BMI) at 10 years of age using standardized BMIs from birth to 5 years. Parental education, family income and maternal smoking during pregnancy were considered as covariates. Linear and logistic regression models were used to evaluate the impact of risk factors on BMI and on being overweight at 10 years of age, respectively.
Results:
Birth weight, standardized BMI at 5 years (60–64 months) (
β
=0.77; 95% confidence interval (CI): 0.73–0.81) and maternal smoking during pregnancy were positively associated with standardized BMI at 10 years of age. Standardized BMI and overweight at 5 years were strongest predictors of being overweight at 10 years. Conversely, high parental education conferred a protective effect (
β
=−0.15; 95% CI: −0.29 to −0.01). Being overweight at 5 years (60–64 months) increased the risk of being overweight at 10 years of age with odds ratios above 10. Among children who were predicted to be overweight at 10 years, cross-validation results showed that 76.8% of female subjects and 68.1% of male subjects would be overweight at 10 years of age.
Conclusion:
BMI and being overweight at 5 years of age are strong predictors of being overweight at 10 years of age. The effectiveness of targeted interventions in children who are overweight at 5 years of age should be explored.</description><subject>692/499</subject><subject>692/699/1702/393</subject><subject>692/700/1720</subject><subject>Age Factors</subject><subject>Air pollution</subject><subject>Allergies</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Clinical Nutrition</subject><subject>Cohort Studies</subject><subject>Education</subject><subject>Educational Status</subject><subject>Epidemiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Females</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics</subject><subject>Germany</subject><subject>Humans</subject><subject>Immune system</subject><subject>Infants</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Obesity - etiology</subject><subject>Odds Ratio</subject><subject>Original</subject><subject>original-article</subject><subject>Overweight - complications</subject><subject>Parents</subject><subject>Physiological aspects</subject><subject>Prediction models</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Prevalence studies (Epidemiology)</subject><subject>Public Health</subject><subject>Risk Factors</subject><subject>Risk factors (Health)</subject><subject>Sex Factors</subject><subject>Smoking</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks-LEzEUxwdR3HX15lkConiwNZlkfnkQyrLWQtGDeg5vMm9mUtNkN5lZ6X9vxq27rZQQwsv3837ykuQlo3NGefkBN8rOU8r4vKSPknMminyW5YI-Ts5plYkZp7Q4S56FsKE0ikX6NDlLec7SjBXnye4KvNkRo1skXodfpAU1OB-Ia0mN2nbE3aL_jbrrBwIDYZTsEO506PAj8RhGM_y1hx7JEv0WLKm1H3qiXO981Jarr6trMwYCtiHr1ffFZDxPnrRgAr7YvxfJz89XPy6_zNbflqvLxXqmclENsfwsrSjnPKMKWB37ZFmpIN6mFQKh5BVrIBUFq0HVUDWFYJFsmrrFqiwEv0g-3cW9HustNgrt4MHIa6-34HfSgZbHitW97Nyt5AXPM1bFAO_2Aby7GTEMcquDQmPAohuDZEKUKcvTdEJf_4du3OhtbC9SrGQ5z0TxQHVgUGrbuphXTUHlgvMqpVxkU92zE1SHFmORzmKr4_cRPz_Bx9PgVquTDm8PHHoEM_TBmXHQzoZj8P0dqLwLwWN7PzxG5bSDctpBOe2gLGnEXx0O_B7-t3QReLMHICgwrQerdHjgiqyqaHowgRAl26E_mOapxH8AOy_www</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Pei, Z</creator><creator>Flexeder, C</creator><creator>Fuertes, E</creator><creator>Thiering, E</creator><creator>Koletzko, B</creator><creator>Cramer, C</creator><creator>Berdel, D</creator><creator>Lehmann, I</creator><creator>Bauer, C-P</creator><creator>Heinrich, J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7TS</scope><scope>7TV</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20130801</creationdate><title>Early life risk factors of being overweight at 10 years of age: results of the German birth cohorts GINIplus and LISAplus</title><author>Pei, Z ; Flexeder, C ; Fuertes, E ; Thiering, E ; Koletzko, B ; Cramer, C ; Berdel, D ; Lehmann, I ; Bauer, C-P ; Heinrich, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c649t-30529033350ca1b013158ca58cdf44ea8391da2471bacba9d7410caddbfe98743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>692/499</topic><topic>692/699/1702/393</topic><topic>692/700/1720</topic><topic>Age Factors</topic><topic>Air pollution</topic><topic>Allergies</topic><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>Body Mass Index</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Clinical Nutrition</topic><topic>Cohort Studies</topic><topic>Education</topic><topic>Educational Status</topic><topic>Epidemiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Females</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics</topic><topic>Germany</topic><topic>Humans</topic><topic>Immune system</topic><topic>Infants</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Obesity - etiology</topic><topic>Odds Ratio</topic><topic>Original</topic><topic>original-article</topic><topic>Overweight - complications</topic><topic>Parents</topic><topic>Physiological aspects</topic><topic>Prediction models</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Prevalence studies (Epidemiology)</topic><topic>Public Health</topic><topic>Risk Factors</topic><topic>Risk factors (Health)</topic><topic>Sex Factors</topic><topic>Smoking</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pei, Z</creatorcontrib><creatorcontrib>Flexeder, C</creatorcontrib><creatorcontrib>Fuertes, E</creatorcontrib><creatorcontrib>Thiering, E</creatorcontrib><creatorcontrib>Koletzko, B</creatorcontrib><creatorcontrib>Cramer, C</creatorcontrib><creatorcontrib>Berdel, D</creatorcontrib><creatorcontrib>Lehmann, I</creatorcontrib><creatorcontrib>Bauer, C-P</creatorcontrib><creatorcontrib>Heinrich, J</creatorcontrib><creatorcontrib>GINIplus and LISAplus Study Group</creatorcontrib><creatorcontrib>for the GINIplus and LISAplus Study Group</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE 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Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pei, Z</au><au>Flexeder, C</au><au>Fuertes, E</au><au>Thiering, E</au><au>Koletzko, B</au><au>Cramer, C</au><au>Berdel, D</au><au>Lehmann, I</au><au>Bauer, C-P</au><au>Heinrich, J</au><aucorp>GINIplus and LISAplus Study Group</aucorp><aucorp>for the GINIplus and LISAplus Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early life risk factors of being overweight at 10 years of age: results of the German birth cohorts GINIplus and LISAplus</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>67</volume><issue>8</issue><spage>855</spage><epage>862</epage><pages>855-862</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Objective:
To develop a prediction model that quantifies the risk of being overweight at 10 years of age.
Subjects/Methods:
In total, 3121 participants from the GINIplus (German Infant Nutritional Intervention plus environmental and genetic influences on allergy development) and LISAplus (Influences of Lifestyle-Related Factors on the Immune System and the Development of Allergies in Childhood plus Air Pollution and Genetics) German birth cohorts were recruited. We predicted standardized body mass index (BMI) at 10 years of age using standardized BMIs from birth to 5 years. Parental education, family income and maternal smoking during pregnancy were considered as covariates. Linear and logistic regression models were used to evaluate the impact of risk factors on BMI and on being overweight at 10 years of age, respectively.
Results:
Birth weight, standardized BMI at 5 years (60–64 months) (
β
=0.77; 95% confidence interval (CI): 0.73–0.81) and maternal smoking during pregnancy were positively associated with standardized BMI at 10 years of age. Standardized BMI and overweight at 5 years were strongest predictors of being overweight at 10 years. Conversely, high parental education conferred a protective effect (
β
=−0.15; 95% CI: −0.29 to −0.01). Being overweight at 5 years (60–64 months) increased the risk of being overweight at 10 years of age with odds ratios above 10. Among children who were predicted to be overweight at 10 years, cross-validation results showed that 76.8% of female subjects and 68.1% of male subjects would be overweight at 10 years of age.
Conclusion:
BMI and being overweight at 5 years of age are strong predictors of being overweight at 10 years of age. The effectiveness of targeted interventions in children who are overweight at 5 years of age should be explored.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23612517</pmid><doi>10.1038/ejcn.2013.80</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
subjects | 692/499 692/699/1702/393 692/700/1720 Age Factors Air pollution Allergies Biological and medical sciences Birth Weight Body Mass Index Child Child, Preschool Children & youth Clinical Nutrition Cohort Studies Education Educational Status Epidemiology Feeding. Feeding behavior Female Females Fundamental and applied biological sciences. Psychology Genetics Germany Humans Immune system Infants Internal Medicine Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Nutrition research Obesity Obesity - etiology Odds Ratio Original original-article Overweight - complications Parents Physiological aspects Prediction models Pregnancy Prenatal Exposure Delayed Effects Prevalence studies (Epidemiology) Public Health Risk Factors Risk factors (Health) Sex Factors Smoking Vertebrates: anatomy and physiology, studies on body, several organs or systems |
title | Early life risk factors of being overweight at 10 years of age: results of the German birth cohorts GINIplus and LISAplus |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T20%3A58%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early%20life%20risk%20factors%20of%20being%20overweight%20at%2010%20years%20of%20age:%20results%20of%20the%20German%20birth%20cohorts%20GINIplus%20and%20LISAplus&rft.jtitle=European%20journal%20of%20clinical%20nutrition&rft.au=Pei,%20Z&rft.aucorp=GINIplus%20and%20LISAplus%20Study%20Group&rft.date=2013-08-01&rft.volume=67&rft.issue=8&rft.spage=855&rft.epage=862&rft.pages=855-862&rft.issn=0954-3007&rft.eissn=1476-5640&rft_id=info:doi/10.1038/ejcn.2013.80&rft_dat=%3Cgale_pubme%3EA339203454%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1418163547&rft_id=info:pmid/23612517&rft_galeid=A339203454&rfr_iscdi=true |