Ordered recruitment of dynactin to the microtubule plus-end is required for efficient initiation of retrograde axonal transport

Long-range retrograde axonal transport in neurons is driven exclusively by the microtubule motor cytoplasmic dynein. The efficient initiation of dynein-mediated transport from the distal axon is critical for normal neuronal function, and neurodegenerative disease-associated mutations have been shown...

Ausführliche Beschreibung