DAPT Enhances the Apoptosis of Human Tongue Carcinoma Cells
Aim To investigate the effect of DAPT （γ-secretase inhibitor） on the growth of human tongue carcinoma cells and to determine the molecular mechanism to enable the potential application of DAPT to the treatment of tongue carcinoma. Methodology Human tongue carcinoma Tca8113 cells were cultured with D...
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| Veröffentlicht in: | International journal of oral science 2009-06, Vol.1 (2), p.81-89 |
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| creator | Grottkau, Brian E Chen, Xi‐rui Friedrich, Claudia C Yang, Xing‐mei Jing, Wei Wu, Yao Cai, Xiao‐xiao Liu, Yu‐rong Huang, Yuan‐ding Lin, Yun‐feng |
| description | Aim To investigate the effect of DAPT （γ-secretase inhibitor） on the growth of human tongue carcinoma cells and to determine the molecular mechanism to enable the potential application of DAPT to the treatment of tongue carcinoma. Methodology Human tongue carcinoma Tca8113 cells were cultured with DAPT. Cell growth was determined using Indigotic Reduction method. The cell cycle and apoptosis were analyzed by flow cytometry. Real-time PCR and Immuno-Fluorescence （IF） were employed to determine the intracellular expression levels. Results DAPT inhibited the growth of human tongue carcinoma Tca8113 cells by inducing G0-G1 cell cycle arrest and apoptosis, The mRNA levels of Hairy/Enhancer of Split-1 （Hes-1）, a target of Notch activation, were reduced by DAPT in a dose-dependent manner. Coincident with this observation, DAPT induced a dose-dependent promotion of constitutive Caspase-3 in Tca8113 cells. Conclusion DAPT may have a therapeutic value for human tongue carcinoma. Moreover, the effects of DAPT in tumor inhibition may arise partly via the modulation of Notch- 1 and Caspase-3. |
| doi_str_mv | 10.4248/ijos.08025 |
| format | Article |
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Methodology Human tongue carcinoma Tca8113 cells were cultured with DAPT. Cell growth was determined using Indigotic Reduction method. The cell cycle and apoptosis were analyzed by flow cytometry. Real-time PCR and Immuno-Fluorescence （IF） were employed to determine the intracellular expression levels. Results DAPT inhibited the growth of human tongue carcinoma Tca8113 cells by inducing G0-G1 cell cycle arrest and apoptosis, The mRNA levels of Hairy/Enhancer of Split-1 （Hes-1）, a target of Notch activation, were reduced by DAPT in a dose-dependent manner. Coincident with this observation, DAPT induced a dose-dependent promotion of constitutive Caspase-3 in Tca8113 cells. Conclusion DAPT may have a therapeutic value for human tongue carcinoma. Moreover, the effects of DAPT in tumor inhibition may arise partly via the modulation of Notch- 1 and Caspase-3.</description><identifier>ISSN: 1674-2818</identifier><identifier>EISSN: 2049-3169</identifier><identifier>DOI: 10.4248/ijos.08025</identifier><identifier>PMID: 20687300</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amyloid Precursor Protein Secretases - antagonists & inhibitors ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - pharmacology ; Apoptosis - drug effects ; Basic Helix-Loop-Helix Transcription Factors - drug effects ; Carcinoma - pathology ; Caspase 3 - drug effects ; Cell Line, Tumor ; Cell Membrane - drug effects ; Cell Nucleus - drug effects ; Cyclin D1 - drug effects ; Dentistry ; Dipeptides - administration & dosage ; Dipeptides - pharmacology ; Dose-Response Relationship, Drug ; G1 Phase - drug effects ; Homeodomain Proteins - drug effects ; Humans ; Medicine ; Oral and Maxillofacial Surgery ; Original Scientific ; original-scientific-article ; Orthopedics ; Receptor, Notch1 - drug effects ; Repressor Proteins - drug effects ; Resting Phase, Cell Cycle - drug effects ; Surgical Orthopedics ; Tongue Neoplasms - pathology ; Transcription Factor HES-1 ; 口腔卫生 ; 细胞凋亡 ; 舌鳞癌细胞</subject><ispartof>International journal of oral science, 2009-06, Vol.1 (2), p.81-89</ispartof><rights>West China School of Stomatology 2009</rights><rights>Copyright Nature Publishing Group Jun 2009</rights><rights>Copyright © 2009 West China School of Stomatology 2009 West China School of Stomatology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-b76163c77159557ec9240acf28ef5ab1d93dd81f23bd64655891e205db07b2783</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/89520X/89520X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735796/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735796/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://doi.org/10.4248/ijos.08025$$EView_record_in_Springer_Nature$$FView_record_in_$$GSpringer_Nature</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20687300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grottkau, Brian E</creatorcontrib><creatorcontrib>Chen, Xi‐rui</creatorcontrib><creatorcontrib>Friedrich, Claudia C</creatorcontrib><creatorcontrib>Yang, Xing‐mei</creatorcontrib><creatorcontrib>Jing, Wei</creatorcontrib><creatorcontrib>Wu, Yao</creatorcontrib><creatorcontrib>Cai, Xiao‐xiao</creatorcontrib><creatorcontrib>Liu, Yu‐rong</creatorcontrib><creatorcontrib>Huang, Yuan‐ding</creatorcontrib><creatorcontrib>Lin, Yun‐feng</creatorcontrib><title>DAPT Enhances the Apoptosis of Human Tongue Carcinoma Cells</title><title>International journal of oral science</title><addtitle>Int J Oral Sci</addtitle><addtitle>International Journal of Oral Science</addtitle><description>Aim To investigate the effect of DAPT （γ-secretase inhibitor） on the growth of human tongue carcinoma cells and to determine the molecular mechanism to enable the potential application of DAPT to the treatment of tongue carcinoma. Methodology Human tongue carcinoma Tca8113 cells were cultured with DAPT. Cell growth was determined using Indigotic Reduction method. The cell cycle and apoptosis were analyzed by flow cytometry. Real-time PCR and Immuno-Fluorescence （IF） were employed to determine the intracellular expression levels. Results DAPT inhibited the growth of human tongue carcinoma Tca8113 cells by inducing G0-G1 cell cycle arrest and apoptosis, The mRNA levels of Hairy/Enhancer of Split-1 （Hes-1）, a target of Notch activation, were reduced by DAPT in a dose-dependent manner. Coincident with this observation, DAPT induced a dose-dependent promotion of constitutive Caspase-3 in Tca8113 cells. Conclusion DAPT may have a therapeutic value for human tongue carcinoma. Moreover, the effects of DAPT in tumor inhibition may arise partly via the modulation of Notch- 1 and Caspase-3.</description><subject>Amyloid Precursor Protein Secretases - antagonists & inhibitors</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Basic Helix-Loop-Helix Transcription Factors - drug effects</subject><subject>Carcinoma - pathology</subject><subject>Caspase 3 - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell Membrane - drug effects</subject><subject>Cell Nucleus - drug effects</subject><subject>Cyclin D1 - drug effects</subject><subject>Dentistry</subject><subject>Dipeptides - administration & dosage</subject><subject>Dipeptides - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>G1 Phase - drug effects</subject><subject>Homeodomain Proteins - drug effects</subject><subject>Humans</subject><subject>Medicine</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Original Scientific</subject><subject>original-scientific-article</subject><subject>Orthopedics</subject><subject>Receptor, Notch1 - drug effects</subject><subject>Repressor Proteins - drug effects</subject><subject>Resting Phase, Cell Cycle - drug effects</subject><subject>Surgical Orthopedics</subject><subject>Tongue Neoplasms - pathology</subject><subject>Transcription Factor HES-1</subject><subject>口腔卫生</subject><subject>细胞凋亡</subject><subject>舌鳞癌细胞</subject><issn>1674-2818</issn><issn>2049-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkVtLwzAYhoMobk5v_AFS9E6p5tAciiCMeQRBL-Z1SNN06-ySLWkF_72Zm0PBqwS-J-_78QSAYwQvM5yJq3rmwiUUENMd0Mcwy1OCWL4L-ojxLMUCiR44CGEGIRMUo33Qw_HGCYR9cH07fB0nd3aqrDYhaacmGS7conWhDomrksdurmwydnbSmWSkvK6tm6tkZJomHIK9SjXBHG3OAXi7vxuPHtPnl4en0fA51RkTbVpwhhjRnCOaU8qNznEGla6wMBVVBSpzUpYCVZgUJcsYpSJHBkNaFpAXmAsyADfr3EVXzE2pjW29auTC13PlP6VTtfw7sfVUTtyHJJxQnrMYcLYJ8G7ZmdDKmeu8jTtLJCDELOcRHYDzNaW9C8GbatuAoFyJlivR8lt0hE9-77RFf8xG4GINhDiyE-N_df4Xd7rpnkbVy_hAFkq_V3VjJIFC8Phz5Av5DpIm</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Grottkau, Brian E</creator><creator>Chen, Xi‐rui</creator><creator>Friedrich, Claudia C</creator><creator>Yang, Xing‐mei</creator><creator>Jing, Wei</creator><creator>Wu, Yao</creator><creator>Cai, Xiao‐xiao</creator><creator>Liu, Yu‐rong</creator><creator>Huang, Yuan‐ding</creator><creator>Lin, Yun‐feng</creator><general>Nature Publishing Group UK</general><general>Springer Nature B.V</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20090601</creationdate><title>DAPT Enhances the Apoptosis of Human Tongue Carcinoma Cells</title><author>Grottkau, Brian E ; Chen, Xi‐rui ; Friedrich, Claudia C ; Yang, Xing‐mei ; Jing, Wei ; Wu, Yao ; Cai, Xiao‐xiao ; Liu, Yu‐rong ; Huang, Yuan‐ding ; Lin, Yun‐feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-b76163c77159557ec9240acf28ef5ab1d93dd81f23bd64655891e205db07b2783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Amyloid Precursor Protein Secretases - 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drug effects</topic><topic>Resting Phase, Cell Cycle - drug effects</topic><topic>Surgical Orthopedics</topic><topic>Tongue Neoplasms - pathology</topic><topic>Transcription Factor HES-1</topic><topic>口腔卫生</topic><topic>细胞凋亡</topic><topic>舌鳞癌细胞</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grottkau, Brian E</creatorcontrib><creatorcontrib>Chen, Xi‐rui</creatorcontrib><creatorcontrib>Friedrich, Claudia C</creatorcontrib><creatorcontrib>Yang, Xing‐mei</creatorcontrib><creatorcontrib>Jing, Wei</creatorcontrib><creatorcontrib>Wu, Yao</creatorcontrib><creatorcontrib>Cai, Xiao‐xiao</creatorcontrib><creatorcontrib>Liu, Yu‐rong</creatorcontrib><creatorcontrib>Huang, Yuan‐ding</creatorcontrib><creatorcontrib>Lin, Yun‐feng</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of oral science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Grottkau, Brian E</au><au>Chen, Xi‐rui</au><au>Friedrich, Claudia C</au><au>Yang, Xing‐mei</au><au>Jing, Wei</au><au>Wu, Yao</au><au>Cai, Xiao‐xiao</au><au>Liu, Yu‐rong</au><au>Huang, Yuan‐ding</au><au>Lin, Yun‐feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DAPT Enhances the Apoptosis of Human Tongue Carcinoma Cells</atitle><jtitle>International journal of oral science</jtitle><stitle>Int J Oral Sci</stitle><addtitle>International Journal of Oral Science</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>1</volume><issue>2</issue><spage>81</spage><epage>89</epage><pages>81-89</pages><issn>1674-2818</issn><eissn>2049-3169</eissn><abstract>Aim To investigate the effect of DAPT （γ-secretase inhibitor） on the growth of human tongue carcinoma cells and to determine the molecular mechanism to enable the potential application of DAPT to the treatment of tongue carcinoma. Methodology Human tongue carcinoma Tca8113 cells were cultured with DAPT. Cell growth was determined using Indigotic Reduction method. The cell cycle and apoptosis were analyzed by flow cytometry. Real-time PCR and Immuno-Fluorescence （IF） were employed to determine the intracellular expression levels. Results DAPT inhibited the growth of human tongue carcinoma Tca8113 cells by inducing G0-G1 cell cycle arrest and apoptosis, The mRNA levels of Hairy/Enhancer of Split-1 （Hes-1）, a target of Notch activation, were reduced by DAPT in a dose-dependent manner. Coincident with this observation, DAPT induced a dose-dependent promotion of constitutive Caspase-3 in Tca8113 cells. Conclusion DAPT may have a therapeutic value for human tongue carcinoma. Moreover, the effects of DAPT in tumor inhibition may arise partly via the modulation of Notch- 1 and Caspase-3.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20687300</pmid><doi>10.4248/ijos.08025</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amyloid Precursor Protein Secretases - antagonists & inhibitors Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Apoptosis - drug effects Basic Helix-Loop-Helix Transcription Factors - drug effects Carcinoma - pathology Caspase 3 - drug effects Cell Line, Tumor Cell Membrane - drug effects Cell Nucleus - drug effects Cyclin D1 - drug effects Dentistry Dipeptides - administration & dosage Dipeptides - pharmacology Dose-Response Relationship, Drug G1 Phase - drug effects Homeodomain Proteins - drug effects Humans Medicine Oral and Maxillofacial Surgery Original Scientific original-scientific-article Orthopedics Receptor, Notch1 - drug effects Repressor Proteins - drug effects Resting Phase, Cell Cycle - drug effects Surgical Orthopedics Tongue Neoplasms - pathology Transcription Factor HES-1 口腔卫生 细胞凋亡 舌鳞癌细胞 |
| title | DAPT Enhances the Apoptosis of Human Tongue Carcinoma Cells |
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