CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction

ABSTRACT Adequate methadone dosing in methadone maintenance treatment (MMT) for opioid addiction is critical for therapeutic success. One of the challenges in dose determination is the inter‐individual variability in dose‐response. Methadone metabolism is attributed primarily to cytochrome P450 enzy...

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Veröffentlicht in:	Addiction biology 2013-07, Vol.18 (4), p.709-716
Hauptverfasser:	Levran, Orna, Peles, Einat, Hamon, Sara, Randesi, Matthew, Adelson, Miriam, Kreek, Mary Jeanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Addiction Adolescent Adult Aged Analgesics, Opioid - administration & dosage Analgesics, Opioid - metabolism Analgesics, Opioid - pharmacokinetics Analysis of Variance Ancestry informative markers Aryl Hydrocarbon Hydroxylases - genetics CYP2B6 Cytochrome P-450 CYP2B6 Dose-Response Relationship, Drug Ethnic Groups - ethnology Ethnic Groups - genetics Female Gene Frequency Heterozygote Homozygote Humans Israel Israel - ethnology Linkage Disequilibrium Male methadone Methadone - administration & dosage Methadone - metabolism Methadone - pharmacokinetics Middle Aged Opiate Substitution Treatment opioid addiction Opioid-Related Disorders - drug therapy Opioid-Related Disorders - genetics Oxidoreductases, N-Demethylating - genetics Pharmacogenetics pharmacogenomics Polymorphism, Single Nucleotide - genetics Precision Medicine Sequence Analysis, DNA - methods Young Adult
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