Chimeric molecules facilitate the degradation of androgen receptors and repress the growth of LNCaP cells

Post-translational degradation of protein plays an important role in cell life. We employed chimeric molecules (dihydrotestosterone-based proteolysis-targeting chimeric molecule [DHT-PROTAC]) to facilitate androgen receptor (AR) degradation via the ubiquitin-proteasome pathway (UPP) and to investiga...

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Veröffentlicht in:	Asian journal of andrology 2009-01, Vol.11 (1), p.119-126
Hauptverfasser:	Tang, Yue-Qing, Han, Bang-Min, Yao, Xin-Quan, Hong, Yan, Wang, Yan, Zhao, Fu-Jun, Yu, Sheng-Qiang, Sun, Xiao-Wen, Xia, Shu-Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Dihydrotestosterone - pharmacology Dose-Response Relationship, Drug Humans Male Original Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proteasome Endopeptidase Complex - metabolism Receptors, Androgen - metabolism Recombinant Fusion Proteins - pharmacology Recombinant Fusion Proteins - therapeutic use Signal Transduction - drug effects Ubiquitin - metabolism
Online-Zugang:	Volltext
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