Deconstruction of the SS18-SSX Fusion Oncoprotein Complex: Insights into Disease Etiology and Therapeutics

Synovial sarcoma is a translocation-associated sarcoma where the underlying chromosomal event generates SS18-SSX fusion transcripts. In vitro and in vivo studies have shown that the SS18-SSX fusion oncoprotein is both necessary and sufficient to support tumorigenesis; however, its mechanism of actio...

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Veröffentlicht in:	Cancer cell 2012-03, Vol.21 (3), p.333-347
Hauptverfasser:	Su, Le, Sampaio, Arthur V., Jones, Kevin B., Pacheco, Marina, Goytain, Angela, Lin, Shujun, Poulin, Neal, Yi, Lin, Rossi, Fabio M., Kast, Juergen, Capecchi, Mario R., Underhill, T. Michael, Nielsen, Torsten O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 2 - metabolism Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Cell Line, Tumor Cell Proliferation - drug effects Gene Expression Regulation, Neoplastic Gene Knockdown Techniques HEK293 Cells Histone Deacetylase Inhibitors - pharmacology Humans Mice Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Oncogene Proteins, Fusion - physiology Repressor Proteins - metabolism RNA, Small Interfering Sarcoma, Synovial - genetics Sarcoma, Synovial - metabolism Translocation, Genetic
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