Silencing of CXCR4 blocks breast cancer metastasis

RNA interference technology, silencing targeted genes in mammalian cells, has become a powerful tool for studying gene function. For the first time in cancer research, we show that direct injection of a pool of naked small interfering RNA (siRNA) duplexes can prevent tumorigenesis in an animal model...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-02, Vol.65 (3), p.967-971
Hauptverfasser:	ZHONGXING LIANG, YOUNGHYOUN YOON, VOTAW, John, GOODMAN, Mark M, WILLIAMS, Larry, SHIM, Hyunsuk
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - pathology Breast Neoplasms - therapy Cell Line, Tumor Female Gene Silencing Genetic Therapy - methods Gynecology. Andrology. Obstetrics Lung Neoplasms - prevention & control Lung Neoplasms - secondary Mammary gland diseases Medical sciences Mice Mice, SCID Pharmacology. Drug treatments Receptors, CXCR4 - antagonists & inhibitors Receptors, CXCR4 - genetics RNA, Messenger - biosynthesis RNA, Messenger - chemistry RNA, Small Interfering - genetics RNA, Small Interfering - pharmacology Tumors
Online-Zugang:	Volltext
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