Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats

Many reports have shown that autophagy has a role as both a promoter and inhibitor in tumor development. However, the mechanism of this paradox is unknown. Tumor development is a multistep process. Therefore, we investigated whether the role of autophagy in hepatocarcinoma formation depended on the...

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Veröffentlicht in:	Cell death & disease 2013-02, Vol.4 (2), p.e501-e501
Hauptverfasser:	Sun, K, Guo, X-l, Zhao, Q-d, jing, Y-y, Kou, X-r, Xie, X-q, Zhou, Y, Cai, N, Gao, L, Zhao, X, Zhang, S-s, Song, J-r, Li, D, Deng, W-j, Li, R, Wu, M-c, Wei, L-x
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/2327 631/80/82/39 692/420/755 692/699/1503/1504/1610 Animals Antibodies Antioxidants - pharmacology Autophagy - drug effects Biochemistry Biomedical and Life Sciences Carcinoma, Hepatocellular - chemically induced Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - prevention & control Cell Biology Cell Culture Cell Proliferation - drug effects Cell Transformation, Neoplastic - drug effects Chloroquine - pharmacology Cytokines - metabolism Diethylnitrosamine - toxicity DNA Damage Immunology Life Sciences Liver - metabolism Liver Neoplasms - chemically induced Liver Neoplasms - mortality Liver Neoplasms - prevention & control Male Original original-article Protective Agents - pharmacology Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Survival Rate Up-Regulation
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