Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells

We investigated the molecular mechanisms underlying the effect of sorafenib and SC-59, a novel sorafenib derivative, on hepatocellular carcinoma (HCC). Sorafenib activated autophagy in a dose- and time-dependent manner in the HCC cell lines PLC5, Sk-Hep1, HepG2 and Hep3B. Sorafenib downregulated pho...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell death & disease 2013-02, Vol.4 (2), p.e485-e485
Hauptverfasser:	Tai, W-T, Shiau, C-W, Chen, H-L, Liu, C-Y, Lin, C-S, Cheng, A-L, Chen, P-J, Chen, K-F
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/99 631/80/82/39 631/92/436/2388 692/699/67/1504/1610 Animals Antibodies Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Apoptosis - drug effects Apoptosis Regulatory Proteins - antagonists & inhibitors Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Beclin-1 Biochemistry Biomedical and Life Sciences Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Biology Cell Culture Cell Line, Tumor Down-Regulation - drug effects Hep G2 Cells Humans Immunology Life Sciences Liver Neoplasms - metabolism Liver Neoplasms - pathology Membrane Proteins - antagonists & inhibitors Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Nude Myeloid Cell Leukemia Sequence 1 Protein Niacinamide - analogs & derivatives Niacinamide - therapeutic use Niacinamide - toxicity Original original-article Phenylurea Compounds - chemistry Phenylurea Compounds - pharmacology Phenylurea Compounds - therapeutic use Phenylurea Compounds - toxicity Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 6 - antagonists & inhibitors Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism RNA Interference RNA, Small Interfering - metabolism STAT3 Transcription Factor - metabolism Transplantation, Heterologous
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!