The vascular endothelium masks the persistent inhibition of rat thoracic arterial tone induced by S-nitrosoglutathione

In endothelium-denuded arteries, the nitric oxide (NO) donor S-nitrosoglutathione (GSNO) induced a persistent hypo-reactivity to vasoconstrictors, and low-molecular weight thiols such as N-acetyl cysteine (NAC) produced a relaxant effect. These effects were attributed to the formation of vascular NO...

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Veröffentlicht in:	Cardiovascular Journal of Africa 2011-01, Vol.22 (1), p.7-13
Hauptverfasser:	Sarr, M, Sar, F B, Gueye, L, Kane, M O, Wele, A, Diallo, A S, Schini-Kerth, V, Muller, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Biochemistry, Molecular Biology Cardiovascular Topics Cellular Biology Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enzyme Inhibitors - pharmacology Guanylate Cyclase - antagonists & inhibitors Guanylate Cyclase - metabolism In Vitro Techniques Life Sciences Male Microscopy, Confocal Nitric Oxide - metabolism Nitric Oxide Donors - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Potassium Channel Blockers - pharmacology Potassium Channels - drug effects Potassium Channels - metabolism Rats Rats, Wistar S-Nitrosoglutathione - pharmacology Sulfhydryl Compounds - metabolism Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vasodilator Agents - pharmacology
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