Functional Cloning of Recurrence-specific Antigens Identifies Molecular Targets to Treat Tumor Relapse

Aggressive regrowth of recurrent tumors following treatment-induced dormancy represents a major clinical challenge for treatment of malignant disease. We reported previously that recurrent prostate tumors, which underwent complete macroscopic regression followed by aggressive regrowth, could be cure...

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Veröffentlicht in:	Molecular therapy 2013-08, Vol.21 (8), p.1507-1516
Hauptverfasser:	Boisgerault, Nicolas, Kottke, Timothy, Pulido, Jose, Thompson, Jill, Diaz, Rosa Maria, Rommelfanger-Konkol, Diana, Embry, Addie, Saenz, Dyana, Poeschla, Eric, Pandha, Hardev, Harrington, Kevin, Melcher, Alan, Selby, Peter, Vile, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - pharmacology Antigens Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Cancer therapies Cell Line, Tumor Chemotherapy Cloning Disease Models, Animal DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - immunology DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology Doxorubicin - pharmacology Drug Resistance, Neoplasm - genetics Drug Resistance, Neoplasm - immunology Enzymes Epitopes - genetics Epitopes - immunology Gene Expression Gene Library Genetic Therapy Genetic Vectors - genetics Humans Immunotherapy Injections Male Medical research Melanoma Melanoma - genetics Melanoma - immunology Mice Neoplasms - genetics Neoplasms - immunology Neoplasms - mortality Neoplasms - therapy Original Phenotype Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - immunology Recurrence Topoisomerase II Inhibitors - pharmacology Tumor Escape - genetics Tumor Escape - immunology Tumors Vesicular stomatitis Indiana virus - genetics Vesicular stomatitis virus Viral infections Viruses
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