Systemic Delivery of Fusogenic Membrane Glycoprotein-expressing Neural Stem Cells to Selectively Kill Tumor Cells

Intravenously injected neural stem cells (NSCs) can infiltrate both primary and metastatic tumor sites; thus, they are attractive tumor-targeting vehicles for delivering anticancer agents. However, because the systemic distribution of the injected NSCs involves normal organs and might induce off-tar...

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Veröffentlicht in:	Molecular therapy 2013-08, Vol.21 (8), p.1621-1630
Hauptverfasser:	Zhu, Detu, Lam, Dang Hoang, Purwanti, Yovita Ida, Goh, Sal Lee, Wu, Chunxiao, Zeng, Jieming, Fan, Weimin, Wang, Shu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Brain cancer Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - therapy Cancer therapies Cell Death Cell Line, Tumor Cell- and Tissue-Based Therapy Disease Models, Animal Female Gene therapy Genes, Transgenic, Suicide Genetic Therapy Giant Cells - metabolism Glycoproteins Herpes simplex virus Herpes viruses Humans Hydrogen-Ion Concentration Induced Pluripotent Stem Cells - metabolism Kinases Lungs Medical prognosis Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Metastasis Mice Neoplasm Metastasis Neoplasms - metabolism Neoplasms - mortality Neoplasms - pathology Neoplasms - therapy Neural Stem Cells - metabolism Neural Stem Cells - transplantation Original Plasmids Proteins Sensors Stem cells Tumors Veins & arteries Vesicular stomatitis virus Viral Envelope Proteins - genetics Viral Envelope Proteins - metabolism
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