Abnormal ghrelin secretion contributes to gastrointestinal symptoms in multiple system atrophy patients
Patients with multiple system atrophy (MSA) often have evidence of compromised gastrointestinal motility. Ghrelin is a gut hormone that influences gastrointestinal motility in humans. The aim of this study was to determine whether ghrelin secretion is affected in MSA patients, and to investigate the...
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| Veröffentlicht in: | Journal of neurology 2013-08, Vol.260 (8), p.2073-2077 |
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| creator | Ozawa, Tetsutaro Tokunaga, Jun Arakawa, Musashi Ishikawa, Atsushi Takeuchi, Ryoko Mezaki, Naomi Miura, Takeshi Sakai, Naoko Hokari, Mariko Takeshima, Akari Utsumi, Kota Kondo, Takashi Yokoseki, Akio Nishizawa, Masatoyo |
| description | Patients with multiple system atrophy (MSA) often have evidence of compromised gastrointestinal motility. Ghrelin is a gut hormone that influences gastrointestinal motility in humans. The aim of this study was to determine whether ghrelin secretion is affected in MSA patients, and to investigate the relation between ghrelin secretion and gastrointestinal symptoms. Plasma levels of active ghrelin and unacylated ghrelin were measured in patients with MSA (
n
= 30), other atypical parkinsonian disorders including progressive supranuclear palsy-Richardson syndrome and corticobasal syndrome (
n
= 24), and control subjects (
n
= 24) using enzyme-linked immunosorbent assays. Gastrointestinal symptoms were quantified in all subjects using a self-report questionnaire. The ratio of active ghrelin to total ghrelin in the plasma (active ghrelin ratio) was lower in patients with MSA (mean: 8.0 %) than in patients with other atypical parkinsonian disorders (mean: 13.7 %,
P
= 0.001) and control subjects (mean: 13.9 %,
P
= 0.001). The active ghrelin ratio was correlated with the severity of gastrointestinal symptoms in MSA (
r
= −0.5,
P
= 0.004). Our observations indicate that ghrelin secretion is affected in patients with MSA. The low active ghrelin ratio may contribute to gastrointestinal symptoms in MSA. |
| doi_str_mv | 10.1007/s00415-013-6944-9 |
| format | Article |
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n
= 30), other atypical parkinsonian disorders including progressive supranuclear palsy-Richardson syndrome and corticobasal syndrome (
n
= 24), and control subjects (
n
= 24) using enzyme-linked immunosorbent assays. Gastrointestinal symptoms were quantified in all subjects using a self-report questionnaire. The ratio of active ghrelin to total ghrelin in the plasma (active ghrelin ratio) was lower in patients with MSA (mean: 8.0 %) than in patients with other atypical parkinsonian disorders (mean: 13.7 %,
P
= 0.001) and control subjects (mean: 13.9 %,
P
= 0.001). The active ghrelin ratio was correlated with the severity of gastrointestinal symptoms in MSA (
r
= −0.5,
P
= 0.004). Our observations indicate that ghrelin secretion is affected in patients with MSA. The low active ghrelin ratio may contribute to gastrointestinal symptoms in MSA.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-013-6944-9</identifier><identifier>PMID: 23652420</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Antiparkinson Agents - therapeutic use ; Atrophy ; Autonomic Nervous System Diseases - etiology ; Autonomic Nervous System Diseases - physiopathology ; Dementia ; Enzymes ; Fecal incontinence ; Female ; Gastrointestinal Diseases - diagnosis ; Gastrointestinal Diseases - etiology ; Gastrointestinal Diseases - metabolism ; Ghrelin - blood ; Ghrelin - secretion ; Growth hormones ; Hormones - blood ; Humans ; Levodopa - therapeutic use ; Male ; Medicine ; Medicine & Public Health ; Motility ; Multiple System Atrophy - complications ; Multiple System Atrophy - metabolism ; Multiple System Atrophy - physiopathology ; Nervous system ; Neurology ; Neuroradiology ; Neurosciences ; Original Communication ; Plasma</subject><ispartof>Journal of neurology, 2013-08, Vol.260 (8), p.2073-2077</ispartof><rights>The Author(s) 2013</rights><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-60b261dc3a0fa24af967e2fb2c6300fec79fcb747146bd6c6a1d16f51792d4803</citedby><cites>FETCH-LOGICAL-c569t-60b261dc3a0fa24af967e2fb2c6300fec79fcb747146bd6c6a1d16f51792d4803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-013-6944-9$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-013-6944-9$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23652420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozawa, Tetsutaro</creatorcontrib><creatorcontrib>Tokunaga, Jun</creatorcontrib><creatorcontrib>Arakawa, Musashi</creatorcontrib><creatorcontrib>Ishikawa, Atsushi</creatorcontrib><creatorcontrib>Takeuchi, Ryoko</creatorcontrib><creatorcontrib>Mezaki, Naomi</creatorcontrib><creatorcontrib>Miura, Takeshi</creatorcontrib><creatorcontrib>Sakai, Naoko</creatorcontrib><creatorcontrib>Hokari, Mariko</creatorcontrib><creatorcontrib>Takeshima, Akari</creatorcontrib><creatorcontrib>Utsumi, Kota</creatorcontrib><creatorcontrib>Kondo, Takashi</creatorcontrib><creatorcontrib>Yokoseki, Akio</creatorcontrib><creatorcontrib>Nishizawa, Masatoyo</creatorcontrib><title>Abnormal ghrelin secretion contributes to gastrointestinal symptoms in multiple system atrophy patients</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Patients with multiple system atrophy (MSA) often have evidence of compromised gastrointestinal motility. Ghrelin is a gut hormone that influences gastrointestinal motility in humans. The aim of this study was to determine whether ghrelin secretion is affected in MSA patients, and to investigate the relation between ghrelin secretion and gastrointestinal symptoms. Plasma levels of active ghrelin and unacylated ghrelin were measured in patients with MSA (
n
= 30), other atypical parkinsonian disorders including progressive supranuclear palsy-Richardson syndrome and corticobasal syndrome (
n
= 24), and control subjects (
n
= 24) using enzyme-linked immunosorbent assays. Gastrointestinal symptoms were quantified in all subjects using a self-report questionnaire. The ratio of active ghrelin to total ghrelin in the plasma (active ghrelin ratio) was lower in patients with MSA (mean: 8.0 %) than in patients with other atypical parkinsonian disorders (mean: 13.7 %,
P
= 0.001) and control subjects (mean: 13.9 %,
P
= 0.001). The active ghrelin ratio was correlated with the severity of gastrointestinal symptoms in MSA (
r
= −0.5,
P
= 0.004). Our observations indicate that ghrelin secretion is affected in patients with MSA. The low active ghrelin ratio may contribute to gastrointestinal symptoms in MSA.</description><subject>Aged</subject><subject>Antiparkinson Agents - therapeutic use</subject><subject>Atrophy</subject><subject>Autonomic Nervous System Diseases - etiology</subject><subject>Autonomic Nervous System Diseases - physiopathology</subject><subject>Dementia</subject><subject>Enzymes</subject><subject>Fecal incontinence</subject><subject>Female</subject><subject>Gastrointestinal Diseases - diagnosis</subject><subject>Gastrointestinal Diseases - etiology</subject><subject>Gastrointestinal Diseases - metabolism</subject><subject>Ghrelin - blood</subject><subject>Ghrelin - secretion</subject><subject>Growth hormones</subject><subject>Hormones - blood</subject><subject>Humans</subject><subject>Levodopa - therapeutic use</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Motility</subject><subject>Multiple System Atrophy - complications</subject><subject>Multiple System Atrophy - metabolism</subject><subject>Multiple System Atrophy - physiopathology</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Communication</subject><subject>Plasma</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkUuLFDEUhYMoTtv6A9xIgRs3pTfvykYYBl8w4EbXIZVKVWeoSsokJfS_n7Q9DqMguArJ_c65ufcg9BLDWwwg32UAhnkLmLZCMdaqR2iHGSUtZlw9RjugDFpOObtAz3K-AYCuFp6iC0IFJ4zADk2XfYhpMXMzHZKbfWiys8kVH0NjYyjJ91txuSmxmUwuKfpQr8WHqsjHZS1xyU1VLdtc_Dq7-piLWxpT0fVwbFZTvAslP0dPRjNn9-Lu3KPvHz98u_rcXn_99OXq8rq1XKjSCuiJwIOlBkZDmBmVkI6MPbGCAozOSjXaXjKJmegHYYXBAxYjx1KRgXVA9-j92Xfd-sUNtvZOZtZr8otJRx2N139Wgj_oKf7UVNK6G1oN3twZpPhjq6PqxWfr5tkEF7esMSMSgHJM_gPFHRVCdCfX13-hN3FLdYm_KKl4pyq7R_hM2RRzTm68_zcGfUpcnxPXNXF9Slyrqnn1cOB7xe-IK0DOQK6lMLn0oPU_XW8BSVa5XA</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Ozawa, Tetsutaro</creator><creator>Tokunaga, Jun</creator><creator>Arakawa, Musashi</creator><creator>Ishikawa, Atsushi</creator><creator>Takeuchi, Ryoko</creator><creator>Mezaki, Naomi</creator><creator>Miura, Takeshi</creator><creator>Sakai, Naoko</creator><creator>Hokari, Mariko</creator><creator>Takeshima, Akari</creator><creator>Utsumi, Kota</creator><creator>Kondo, Takashi</creator><creator>Yokoseki, Akio</creator><creator>Nishizawa, Masatoyo</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130801</creationdate><title>Abnormal ghrelin secretion contributes to gastrointestinal symptoms in multiple system atrophy patients</title><author>Ozawa, Tetsutaro ; Tokunaga, Jun ; Arakawa, Musashi ; Ishikawa, Atsushi ; Takeuchi, Ryoko ; Mezaki, Naomi ; Miura, Takeshi ; Sakai, Naoko ; Hokari, Mariko ; Takeshima, Akari ; Utsumi, Kota ; Kondo, Takashi ; Yokoseki, Akio ; Nishizawa, Masatoyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-60b261dc3a0fa24af967e2fb2c6300fec79fcb747146bd6c6a1d16f51792d4803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Antiparkinson Agents - therapeutic use</topic><topic>Atrophy</topic><topic>Autonomic Nervous System Diseases - etiology</topic><topic>Autonomic Nervous System Diseases - physiopathology</topic><topic>Dementia</topic><topic>Enzymes</topic><topic>Fecal incontinence</topic><topic>Female</topic><topic>Gastrointestinal Diseases - diagnosis</topic><topic>Gastrointestinal Diseases - etiology</topic><topic>Gastrointestinal Diseases - metabolism</topic><topic>Ghrelin - blood</topic><topic>Ghrelin - secretion</topic><topic>Growth hormones</topic><topic>Hormones - blood</topic><topic>Humans</topic><topic>Levodopa - therapeutic use</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Motility</topic><topic>Multiple System Atrophy - complications</topic><topic>Multiple System Atrophy - metabolism</topic><topic>Multiple System Atrophy - physiopathology</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Communication</topic><topic>Plasma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozawa, Tetsutaro</creatorcontrib><creatorcontrib>Tokunaga, Jun</creatorcontrib><creatorcontrib>Arakawa, Musashi</creatorcontrib><creatorcontrib>Ishikawa, Atsushi</creatorcontrib><creatorcontrib>Takeuchi, Ryoko</creatorcontrib><creatorcontrib>Mezaki, Naomi</creatorcontrib><creatorcontrib>Miura, Takeshi</creatorcontrib><creatorcontrib>Sakai, Naoko</creatorcontrib><creatorcontrib>Hokari, Mariko</creatorcontrib><creatorcontrib>Takeshima, Akari</creatorcontrib><creatorcontrib>Utsumi, Kota</creatorcontrib><creatorcontrib>Kondo, Takashi</creatorcontrib><creatorcontrib>Yokoseki, Akio</creatorcontrib><creatorcontrib>Nishizawa, Masatoyo</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozawa, Tetsutaro</au><au>Tokunaga, Jun</au><au>Arakawa, Musashi</au><au>Ishikawa, Atsushi</au><au>Takeuchi, Ryoko</au><au>Mezaki, Naomi</au><au>Miura, Takeshi</au><au>Sakai, Naoko</au><au>Hokari, Mariko</au><au>Takeshima, Akari</au><au>Utsumi, Kota</au><au>Kondo, Takashi</au><au>Yokoseki, Akio</au><au>Nishizawa, Masatoyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal ghrelin secretion contributes to gastrointestinal symptoms in multiple system atrophy patients</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>260</volume><issue>8</issue><spage>2073</spage><epage>2077</epage><pages>2073-2077</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><abstract>Patients with multiple system atrophy (MSA) often have evidence of compromised gastrointestinal motility. Ghrelin is a gut hormone that influences gastrointestinal motility in humans. The aim of this study was to determine whether ghrelin secretion is affected in MSA patients, and to investigate the relation between ghrelin secretion and gastrointestinal symptoms. Plasma levels of active ghrelin and unacylated ghrelin were measured in patients with MSA (
n
= 30), other atypical parkinsonian disorders including progressive supranuclear palsy-Richardson syndrome and corticobasal syndrome (
n
= 24), and control subjects (
n
= 24) using enzyme-linked immunosorbent assays. Gastrointestinal symptoms were quantified in all subjects using a self-report questionnaire. The ratio of active ghrelin to total ghrelin in the plasma (active ghrelin ratio) was lower in patients with MSA (mean: 8.0 %) than in patients with other atypical parkinsonian disorders (mean: 13.7 %,
P
= 0.001) and control subjects (mean: 13.9 %,
P
= 0.001). The active ghrelin ratio was correlated with the severity of gastrointestinal symptoms in MSA (
r
= −0.5,
P
= 0.004). Our observations indicate that ghrelin secretion is affected in patients with MSA. The low active ghrelin ratio may contribute to gastrointestinal symptoms in MSA.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23652420</pmid><doi>10.1007/s00415-013-6944-9</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Antiparkinson Agents - therapeutic use Atrophy Autonomic Nervous System Diseases - etiology Autonomic Nervous System Diseases - physiopathology Dementia Enzymes Fecal incontinence Female Gastrointestinal Diseases - diagnosis Gastrointestinal Diseases - etiology Gastrointestinal Diseases - metabolism Ghrelin - blood Ghrelin - secretion Growth hormones Hormones - blood Humans Levodopa - therapeutic use Male Medicine Medicine & Public Health Motility Multiple System Atrophy - complications Multiple System Atrophy - metabolism Multiple System Atrophy - physiopathology Nervous system Neurology Neuroradiology Neurosciences Original Communication Plasma |
| title | Abnormal ghrelin secretion contributes to gastrointestinal symptoms in multiple system atrophy patients |
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