Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes

Prior studies have demonstrated a rapid and progressive acute phase response to bolus aspiration of multi-walled carbon nanotubes (MWCNTs). In this study we sought to test the hypothesis that inhalation exposure to MWCNT produces a fibrotic response and that the response is chronically persistent. T...

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Veröffentlicht in:	Particle and fibre toxicology 2013-07, Vol.10 (1), p.33-33
Hauptverfasser:	Mercer, Robert R, Scabilloni, James F, Hubbs, Ann F, Battelli, Lori A, McKinney, Walter, Friend, Sherri, Wolfarth, Michael G, Andrew, Michael, Castranova, Vincent, Porter, Dale W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Albumins - metabolism Analysis Animal experimentation Animals Aspiration and aspirators Bronchoalveolar Lavage Fluid - chemistry Carbon Collagen Comparative analysis Fibrillar Collagens - metabolism Inhalation Exposure - adverse effects L-Lactate Dehydrogenase - metabolism Lungs Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Male Mice, Inbred C57BL Nanotubes Nanotubes, Carbon - toxicity Neutrophils - drug effects Neutrophils - metabolism Pneumonia - chemically induced Pneumonia - metabolism Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Pulmonary Alveoli - ultrastructure Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Respiration Rodents Studies Time Factors
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