Diagnostic usefulness of pregnancy-associated plasma protein-A in suspected pulmonary embolism

The role of biomarkers for prognostication and diagnosis of pulmonary embolism (PE) is increasing. It has been reported that pregnancy-associated plasma protein-A (PAPP-A) can be used as a proatherosclerotic marker. The present study was aimed to evaluate whether PAPP-A levels are helpful in the dif...

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Veröffentlicht in:	Multidisciplinary respiratory medicine 2013-07, Vol.8 (1), p.49-49, Article 49
Hauptverfasser:	Berk, Serdar, Dogan, Omer Tamer, Aydemir, Eylem Itir, Bingol, Asli, Ozsahin, Sefa Levent, Akkurt, Ibrahim
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Sprache:	eng
Schlagworte:	Biological markers Blood plasma CT imaging Development and progression Diagnosis Lung cancer Original Patient outcomes Physiological aspects Pulmonary embolism
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creator	Berk, Serdar Dogan, Omer Tamer Aydemir, Eylem Itir Bingol, Asli Ozsahin, Sefa Levent Akkurt, Ibrahim
description	The role of biomarkers for prognostication and diagnosis of pulmonary embolism (PE) is increasing. It has been reported that pregnancy-associated plasma protein-A (PAPP-A) can be used as a proatherosclerotic marker. The present study was aimed to evaluate whether PAPP-A levels are helpful in the differential diagnosis of patients presenting with suspected PE. 53 consecutive patients evaluated for suspected PE were prospectively enrolled in the study. Serum PAPP-A levels were measured in the blood samples which were taken at admission. Multi-slice computed tomographic angiography was used to verify the diagnosis of PE. PE was detected in 24 out of the 53 patients, while it was excluded in 29 patients by thorax multi-detector computerized tomography scan. No significant difference was detected in mean serum PAPP-A level between groups (5.72 ± 0.31 mg/L vs. 5.67 ± 0.06 mg/L, respectively). Serum PAPP-A level has no role in the evaluation for PE.
doi_str_mv	10.1186/2049-6958-8-49
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It has been reported that pregnancy-associated plasma protein-A (PAPP-A) can be used as a proatherosclerotic marker. The present study was aimed to evaluate whether PAPP-A levels are helpful in the differential diagnosis of patients presenting with suspected PE. 53 consecutive patients evaluated for suspected PE were prospectively enrolled in the study. Serum PAPP-A levels were measured in the blood samples which were taken at admission. Multi-slice computed tomographic angiography was used to verify the diagnosis of PE. PE was detected in 24 out of the 53 patients, while it was excluded in 29 patients by thorax multi-detector computerized tomography scan. No significant difference was detected in mean serum PAPP-A level between groups (5.72 ± 0.31 mg/L vs. 5.67 ± 0.06 mg/L, respectively). 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It has been reported that pregnancy-associated plasma protein-A (PAPP-A) can be used as a proatherosclerotic marker. The present study was aimed to evaluate whether PAPP-A levels are helpful in the differential diagnosis of patients presenting with suspected PE. 53 consecutive patients evaluated for suspected PE were prospectively enrolled in the study. Serum PAPP-A levels were measured in the blood samples which were taken at admission. Multi-slice computed tomographic angiography was used to verify the diagnosis of PE. PE was detected in 24 out of the 53 patients, while it was excluded in 29 patients by thorax multi-detector computerized tomography scan. No significant difference was detected in mean serum PAPP-A level between groups (5.72 ± 0.31 mg/L vs. 5.67 ± 0.06 mg/L, respectively). 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subjects	Biological markers Blood plasma CT imaging Development and progression Diagnosis Lung cancer Original Patient outcomes Physiological aspects Pulmonary embolism
title	Diagnostic usefulness of pregnancy-associated plasma protein-A in suspected pulmonary embolism
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