The role of MicroRNAs miR-200b and miR-200c in TLR4 signaling and NF-κB activation

Recognition of microbial products by members of the Toll-like receptor (TLR) family initiates intracellular signaling cascades that result in NF-κB activation and subsequent production of inflammatory cytokines. We explored the potential roles of microRNAs (miRNAs) in regulating TLR pathways. A targ...

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Veröffentlicht in:	Innate immunity (London, England) England), 2012-12, Vol.18 (6), p.846-855
Hauptverfasser:	Wendlandt, Erik B, Graff, Joel W, Gioannini, Theresa L, McCaffrey, Anton P, Wilson, Mary E
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptor proteins Chemokine CXCL9 - genetics Chemokine CXCL9 - metabolism Cytokines Data processing Down-Regulation HEK293 Cells Host-Pathogen Interactions Humans Immunity, Innate - genetics Inflammation Interleukin 6 Interleukin-6 - genetics Interleukin-6 - metabolism Intracellular signalling IRAK protein Lipopolysaccharides - immunology MicroRNAs - genetics MicroRNAs - metabolism miRNA Monocytes Monocytes - immunology MyD88 protein Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism NF- Kappa B protein NF-kappa B - genetics NF-kappa B - metabolism Pathogens Plasmids Signal transduction Signal Transduction - genetics Signal Transduction - immunology TLR4 protein Toll-Like Receptor 4 - agonists Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Transcriptional Activation - genetics Transfection Transgenes - genetics Tumor necrosis factor- alpha Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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